A genetic algorithm for combined topology and shape optimisations

A method to find optimal topology and shape of structures is presented. With the first the optimal distribution of an assigned mass is found using an approach based on homogenisation theory, that seeks in which elements of a meshed domain it is present mass; with the second the discontinuous boundaries are smoothed. The problem of the optimal topology search has an ON/OFF nature and has suggested the employment of genetic algorithms. Thus in this paper a genetic algorithm has been developed, which uses as design variables, in the topology optimisation, the relative densities (with respect to effective material density) 0 or 1 of each element of the structure and, in the shape one, the coordinates of the keypoints of changeable boundaries constituted by curves. In both the steps the aim is that to find the variable sets producing the maximum stiffness of the structure, respecting an upper limit on the employed mass. The structural evaluations are carried out with a FEM commercial code, linked to the algorithm. Some applications have been performed and results compared with solutions reported in literature. \uc2\ua9 2003 Elsevier Science Ltd. All rights reserved

Lay-up optimization for the hull of a racing sailing yacht

Deformability and buckling load of yacht hulls with fiber reinforced plastic sandwich structure depend on the stack sequence of the skins. In this work an optimization of fiber directions of the laminae for a racing yacht is proposed. This procedure has been divided into three parts (i.e. material characterization, surface model definition, lay-up optimization). First of all a set of unidirectional specimens has been realized, by using the same fibers and matrix (carbon/epoxy) used for the hull as well as the same procedure and workers, in order to characterize the material according to American Society for Testing and Materials (ASTM) Standard D3039, employing strain gage technique. In the second part, by means of an original software in Turbo-Pascal (which uses the half-width value matrix as an input) linked to Pro/ENGINEER, it has been possible to obtain the body plan and surface and finite element (FE) models of the sailing yacht for the subsequent analyses. In the third step, an optimization procedure that uses the results of FE structural analyses in three different sailing configurations is performed, with the aim of obtaining the fiber directions that are able to minimize the yacht deformability, also taking into account the buckling loads. An approximate analytical model has been used in conjunction with a sweep technique in order to evaluate the best of the solutions

Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy

The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins. Genetic proteinopathies may occur either in the presence of a normal chaperoning system, which is unable to assist the defective myelin protein in its folding and migration, or due to mutations in chaperone genes, leading to functional defects in assisting myelin maturation/migration. The latter are a subgroup of genetic chaperonopathies causing demyelination. In this brief review, we describe some paradigmatic examples pertaining to the chaperonins Hsp60 (HSPD1, or HSP60, or Cpn60) and CCT (chaperonin-containing TCP-1). Our aim is to make scientists and physicians aware of the possibility and advantages of classifying patients depending on the presence or absence of a chaperonopathy. In turn, this subclassification will allow the development of novel therapeutic strategies (chaperonotherapy) by using molecular chaperones as agents or targets for treatment

Lymphatic vessels of the dura mater: A new discovery?

Two recent paper s (Aspelund et al. 2015; Louveau et al. 2015) reported the presence in mice of lymphatics in the cerebra l dura mater , the most external of the meningeal layers covering the brain. This datum was reporte d as a novel discovery in the \ufb01elds of neuroanatomy and neuroim- munology

Low-cost RPAS navigation and guidance system using Square Root Unscented Kalman Filter

Multi-Sensor Data Fusion (MSDF) techniques involving satellite and inertial-based sensors are widely adopted to improve the navigation solution of a number of mission- and safety-critical tasks. Such integrated Navigation and Guidance Systems (NGS) currently do not meet the required level of performance in all flight phases of small Remotely Piloted Aircraft Systems (RPAS). In this paper an innovative Square Root-Unscented Kalman Filter (SR-UKF) based NGS is presented and compared with a conventional UKF governed design. The presented system architectures adopt state-of-the-art information fusion approach based on a number of low-cost sensors including; Global Navigation Satellite Systems (GNSS), Micro-Electro-Mechanical System (MEMS) based Inertial Measurement Unit (IMU) and Vision Based Navigation (VBN) sensors. Additionally, an Aircraft Dynamics Model (ADM), which is essentially a knowledge based module, is employed to compensate for the MEMS-IMU sensor shortcomings in high-dynamics attitude determination tasks. The ADM acts as a virtual sensor and its measurements are processed with non-linear estimation in order to increase the operational validity time. An improvement in the ADM navigation state vector (i.e., position, velocity and attitude) measurements is obtained, thanks to the accurate modeling of aircraft dynamics and advanced processing techniques. An innovative SR-UKF based VBN-IMU-GNSS-ADM (SR-U-VIGA) architecture design was implemented and compared with a typical UKF design (U-VIGA) in a small RPAS (AEROSONDE) integration arrangement exploring a representative cross-section of the operational flight envelope. The comparison of position and attitude data shows that the SR-U-VIGA and U-VIGA NGS fulfill the relevant RNP criteria, including precision approach tasks