On-the-job education as an active source of skills in the professional training of the stomatologist

Introduction: One form of organization of the teaching-learning process is on-the-job education and it is essential to contribute to the improvement of this process. Objective: To describe the development of skills in on-the-job education as an integrating practice of the contents received. Methods: A descriptive study was carried out with 38 students of the Stomatology career of the Faculty of Medical Sciences "Miguel Enriquez", Havana, in February 2020, to whom a survey was applied. Results: 70.83% of the 5th year students consider that they are able to deploy clinical skills, 35.71% of the 4th year students and 66.66% of the 5th year students think that their teachers fulfill their functions in an appropriate way in this process. Conclusions: Very few 4th year students and more than half of the 5th year students assume to be able to develop skills in the clinic and appreciate that their professors perform their functions satisfactorily

La mina de sílex del Neolítico Antiguo de Casa Montero (Madrid, España), 5350-5220 cal a. C.

We present a comprehensive and interpretative overview of the evidence recovered at the mining field of Casa Montero (Madrid, Spain). We describe the technical and social aspects of flint mining in the specific historical context of central Iberia’s Early Neolithic societies. Combination of all the evidence allows us to suggest that mining at the site was probably a generational phenomenon, where the acts of gathering in order to perform a collective action served as a basis for binding new political relations beyond each individual group. Strategic, tactical, and logistic preconditions were required for those gatherings, including the ability and capacity to convene, design, and organize an orderly set of actions such as those deployed at the flint mine. As with other Neolithic mining sites in Europe, understanding these social preconditions are important if archaeologists are to move beyond describing the formal and technical variability of the mines.Presentamos una revisión de conjunto e interpretativa de las evidencias recuperadas en la mina de sílex de Casa Montero (Madrid, España). Describimos los aspectos técnicos y sociales de la minería del sílex en el contexto histórico específico de las sociedades del Neolítico Antiguo de la Península Ibérica. La combinación de todas las evidencias recuperadas nos permite sugerir que la minería en Casa Montero fue probablemente un fenómeno generacional, donde los actos de agregación de pequeños grupos para el desarrollo de acciones colectivas sirvieron de base para establecer nuevas relaciones políticas más allá de cada grupo individual. Para ello se requirieron un conjunto de precondiciones estratégicas, tácticas y logísticas, incluyendo la habilidad y capacidad para convocar, diseñar y organizar un conjunto ordenado de acciones como las que se desarrollaron en la propia mina. Proponemos que estas precondiciones sociales son clave para ir más allá de la variabilidad formal y técnica de las minas

La minería de sílex en Casa Montero. El espacio de la producción.

Este trabajo presenta resultados preliminares de la excavación de la mina del Neolítico Antiguo de Casa Montero (Madrid). Se tratan aspectos descriptivos de las estructuras mineras, el encuadre geológico y los primeros resultados sobre la clasificación petrológica de las muestras de sílex

Small Cell Carcinoma of the Vagina : First Systematic Review of Case Reports and Proposal of a Management Algorithm

Literature search in PubMed and Scopus was performed using the terms "small cell carcinoma" and "vagina." English-language case reports of primary SmCCV up to January 2022 were included. Twenty-nine articles describing 44 cases met our inclusion criteria. We report a new case of our hospital. The global median overall survival (mOS) was 12.00 months (95% CI = 9.31-14.69). The mOS was not reached for stage I, and it was 12.00, 12.00, 9.00, and 8.00 months for stages II, III, IVA, and IVB, respectively (statistically significant differences between stage I and stages II, III, or IVA [log rank p =.003-.017]). Thirty-five cases received local treatments (77.8%). The mOS of patients treated with surgery ± complementary chemotherapy, radiotherapy ± complementary chemotherapy, chemoradiation ± complementary chemotherapy, and surgery + radiotherapy ± complementary chemotherapy were 11.00, 12.00, 17.00, and 29.00 months, respectively. The use of adjuvant or neoadjuvant chemotherapy (64.5%, mostly platinum + etoposide) showed longer mOS (77.00 vs 15.00 months). Four of 5 tested cases presented human papillomavirus infection, 3 of them presenting type 18. Small cell carcinoma of the vagina shows dismal prognosis. Multimodal local management plus complementary chemotherapy seems to achieve better outcomes. Human papillomavirus could be related to the development of SmCCV. A diagnostic-therapeutic algorithm is proposed

Measurement of the α ratio and (n, γ) cross section of 235U from 0.2 to 200 eV at n_TOF

We measured the neutron capture-to-fission cross-section ratio (α ratio) and the capture cross section of 235U between 0.2 and 200 eV at the n_TOF facility at CERN. The simultaneous measurement of neutron-induced capture and fission rates was performed by means of the n_TOF BaF2 Total Absorption Calorimeter (TAC), used for detection of γ rays, in combination with a set of micromegas detectors used as fission tagging detectors. The energy dependence of the capture cross section was obtained with help of the 6 Li(n,t) standard reaction determining the n_TOF neutron fluence; the well-known integral of the 235U(n, f ) cross section between 7.8 and 11 eV was then used for its absolute normalization. The α ratio, obtained with slightly higher statistical fluctuations, was determined directly, without need for any reference cross section. To perform the analysis of this measurement we developed a new methodology to correct the experimentally observed effect that the probabilities of detecting a fission reaction in the TAC and the micromegas detectors are not independent. The results of this work have been used in a new evaluation of 235U performed within the scope of the Collaborative International Evaluated Library Organisation (CIELO) Project, and are consistent with the ENDF/B-VIII.0 and JEFF-3.3 capture cross sections below 4 eV and above 100 eV. However, the measured capture cross section is on average 10% larger between 4 and 100 eV.Ministerio de Economía, Industria y Competitividad de España. FPA2014-53290-C2-1, FPA2016-76765- P y FPA2017-82647-P7º Programa Marco CHANDA de la Comisión Europea. FP7-60520

Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium

This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops demonstrated significant improvements in the NIBUT (12.98 ± 3.22 s) and TBUT (12.95 ± 2.98 s), indicating increased tear stability. Moreover, they reported lower dry eye sensation (6.70 ± 4.94 SPEED score points), suggesting a reduction in DED symptoms. These findings underscore the efficacy of HA/trehalose eyedrops in improving both the objective and subjective signs of DED, with twice-daily application enhancing ocular surface conditions and reducing patient-reported symptoms. © 2023 by the authors

INFRAESTRUCTURAS DE DATOS ESPACIALES Y DATOS DE EXCAVACIÓN ARQUEOLÓGICA: SILEX, LA IDE DE LA MINA NEOLÍTICA DE SÍLEX DE CASA MONTERO (MADRID)

SILEX is a Spatial Data Infrastructure developed for the management and distribution of the primary archaeological information about the Neolithic flint mine of Casa Montero, located in the periphery of the city of Madrid (Spain). It is designed according an open approach, based on the use of standards and open source software and on the free access to the whole data about the site via Internet. It is a distributed information system with a three layer architecture: the data layer, formed by GIS info and a complex entity-relationship thematic database; the web service layer, with the use of standard protocols and languages for accessing the database; and the interface layer, a mashup that combines forms and a geographic viewer for querying and retrieving data.SILEX es una Infraestructura de Datos Espaciales desarrollada para la gestión y distribución de la información arqueológica primaria de la mina de sílex neolítica de Casa Montero, situada en la periferia de la ciudad de Madrid. Ha sido diseñada según un enfoque abierto, basado en el uso de estándares y software de código abierto y en el acceso libre al conjunto integral de los datos relativos a yacimiento vía Internet. Es un sistema de información distribuido con una arquitectura en tres capas: la capa de datos, formada por información SIG y una compleja base de datos temática organizada según el modelo entidad-relación; la capa del servicio web, que incorpora el uso de protocolos y lenguajes estándar para el acceso a la base de datos; y la capa de interfaz, un mashup que combina formularios y un visor geográfico para la consulta y recuperación de la información

Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment

BackgroundObesity (OB) is a chronic metabolic disease with important associated comorbidities and mortality. Vitamin D supplementation is frequently administered after bariatric surgery (BS), so as to reduce OB-related complications, maybe including chronic inflammation.AimThis study aimed to explore relations between vitamin D metabolites and components of the inflammasome machinery in OB before and after BS and their relations with the improvement of metabolic comorbidities.Patients and methodsEpidemiological/clinical/anthropometric/biochemical evaluation was performed in patients with OB at baseline and 6 months after BS. Evaluation of i) vitamin-D metabolites in plasma and ii) components of the inflammasome machinery and inflammatory-associated factors [NOD-like-receptors (NLRs), inflammasome-activation-components, cytokines and inflammation/apoptosis-related components, and cell-cycle and DNA-damage regulators] in peripheral blood mononuclear cells (PBMCs) was performed at baseline and 6 months after BS. Clinical and molecular correlations/associations were analyzed.ResultsSignificant correlations between vitamin D metabolites and inflammasome-machinery components were observed at baseline, and these correlations were significantly reduced 6 months after BS in parallel to a decrease in inflammation markers, fat mass, and body weight. Treatment with calcifediol remarkably increased 25OHD levels, despite 24,25(OH)2D3 remained stable after BS. Several inflammasome-machinery components were associated with improvement in metabolic comorbidities, especially hypertension and dyslipidemia.ConclusionThe beneficial effects of vitamin D on OB-related comorbidities after BS patients are associated with significant changes in the molecular expression of key inflammasome-machinery components. The expression profile of these inflammasome components can be dynamically modulated in PBMCs after BS and vitamin D supplementation, suggesting that this profile could likely serve as a sensor and early predictor of the reversal of OB-related complications after BS