Missing hard states and regular outbursts: the puzzling case of the black hole candidate 4U 1630-472

4U 1630-472 is a recurrent X-ray transient classified as a black-hole candidate from its spectral and timing properties. One of the peculiarities of this source is the presence of regular outbursts with a recurrence period between 600 and 730 d that has been observed since the discovery of the source in 1969. We report on a comparative study on the spectral and timing behaviour of three consecutive outbursts occurred in 2006, 2008 and 2010. We analysed all the data collected by the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) and the Rossi X-ray timing Explorer (RXTE) during these three years of activity. We show that, in spite of having a similar spectral and timing behaviour in the energy range between 3 and 30 keV, these three outbursts show pronounced differences above 30 keV. In fact, the 2010 outburst extends at high energies without any detectable cut-off until 150-200 keV, while the two previous outbursts that occurred in 2006 and 2008 are not detected at all above 30 keV. Thus, in spite of a very similar accretion disk evolution, these three outbursts exhibit totally different characteristics of the Compton electron corona, showing a softening in their evolution rarely observed before in a low mass X-ray binary hosting a black hole. We argue the possibility that the unknown perturbation that causes the outbursts to be equally spaced in time could be at the origin of this particular behaviour. Finally we describe several possible scenarios that could explain the regularity of the outbursts, identifying the most plausible, such as a third body orbiting around the binary system.Comment: April 2015: accepted for publication in MNRAS. May 2015: in pres

Early Social Stress Promotes Inflammation and Disease Risk in Rhesus Monkeys.

Early social stress has potent lifelong health effects. We examined the association of early stress in the attachment relationship (low maternal sensitivity, low MS), lower maternal social hierarchy rank, and greater frequency of group-level social conflict, with biomarkers of inflammatory stress response in plasma (IL-8, MCP-1 and CRP collected two hours after temporary separation from mothers and social groups) and risk for developing a common macaques disease outcome (infectious colitis) in 170 socially-housed rhesus monkeys. We controlled for gene-environment correlations by comparing cross-fostered subjects with infants reared by their biological mothers. Low MS predicted higher levels of pro-inflammatory cytokines and proteins at 3-4 months of age (F(3, 162) = 3.508, p = 0.002, partial eta2 = 0.061) and higher lifetime risk for developing colitis for up to twelve years of age (chi square = 5.919, p = 0.026). Lower maternal social rank (F (3, 162) = 3.789, p = 0.012, partial eta2 = 0.06) and higher rates of social conflict (F (3, 162) = 4.264, p = 0.006, partial eta2 = 0.074) each also predicted greater inflammation in infancy, but not lifetime colitis risk (both p > 0.05). The effects of low MS, lower social rank, and higher social conflict were significant in infants reared by biological mothers and cross-fostered infants, suggesting that our results did not arise from gene-environment correlations, but environmental stressors alone. We conclude that several types of early social stress confer risk for inflammation in infancy, but that stress in the mother-infant relationship may confer the longest-term risk for adverse health outcomes

The first outburst of the black hole candidate MAXI J1836-194 observed by INTEGRAL, Swift, and RXTE

MAXI J1836-194 is a transient black-hole candidate discovered in outburst by MAXI on 30 August 2011. We report on the available INTEGRAL, Swift, and RXTE observations performed in the direction of the source during this event before 55 864 MJD. Combining the broad band (0.6-200 keV) spectral and timing information obtained from these data with the results of radio observations, we show that the event displayed by MAXI J1836-194 is another example of "failed" outburst. During the first ~20 days after the onset of the event, the source underwent a transition from the canonical low/hard to the hard intermediate state, while reaching the highest X-ray flux. In the ~40 days following the peak of the outburst, the source displayed a progressive spectral hardening and a decrease of the X-ray flux, thus it entered again the low/hard state and began its return to quiescence.Comment: Accepted for A&A Letters on 22 Dec. 201

RISCHIO, CRISI E INTERVENTO PUBBLICO NELL'AGRICOLTURA EUROPEA

Esiste un’ampia discussione tra le Istituzioni Europee (Commissione, Parlamento e Governi degli Stati Membri) sull’opportunità di istituire un quadro istituzionale di riferimento a livello europeo per la gestione del rischio e delle crisi in agricoltura. Allo scopo di analizzare la posizione assunta dalla Commissione Europea nel Marzo del 2004, l’articolo discute della possibilità di istituire un tale quadro comune di riferimento date le prospettive cui si trova di fronte la Politica Agricola Comune recentemente riformata. Nel far ciò, vengono passate in rassegna le misure esistenti nei vari Stati Membri e vengono valutati i punti di forza e di debolezza delle opzioni avanzate dalla Commissione. La conclusione è che, dati i vincoli esistenti sulla possibile espansione della spesa in agricoltura, l’istituzione di un programma comune basato sul pagamento di integrazioni di reddito o di sussidi a premi assicurativi è molto poco verosimile. Prospettive migliori sono quelle per un intervento basato sul sostegno di fondi mutualistici tra gli agricoltorie, più in generale, su sostegni indiretti al credito, alle assicurazioni e ai mercati finanziari, orientati al rendere tali strumenti più facilmente accessibili per gli agricoltor

Missing hard states and regular outbursts: the puzzling case of the black hole candidate 4U 1630-472

4U 1630-472 is a recurrent X-ray transient classified as a black hole candidate from its spectral and timing properties. One of the peculiarities of this source is the presence of regular outbursts with a recurrence period between 600 and 730d that has been observed since the discovery of the source in 1969. We report on a comparative study of the spectral and timing behaviour of three consecutive outbursts that occurred in 2006, 2008 and 2010. We have analysed all the data collected by INTEGRAL and the Rossi X-ray Timing Explorer (RXTE) during these three years of activity. We show that, in spite of having a similar spectral and timing behaviour in the energy range between 3 and 30keV, these three outbursts show pronounced differences above 30keV. In fact, the 2010 outburst extends at high energies without any detectable cut-off until 150-200keV, while the two previous outbursts that occurred in 2006 and 2008 are not detected at all above 30keV. Thus, in spite of a very similar accretion disc evolution, these three outbursts exhibit totally different characteristics of the Compton electron corona, showing a softening in their evolution rarely observed before in a low-mass X-ray binary hosting a black hole. We argue the possibility that the unknown perturbation that causes the outbursts to be equally spaced in time could be at the origin of this particular behaviour. Finally, we describe several possible scenarios that could explain the regularity of the outbursts, identifying the most plausible, such as a third body orbiting around the binary syste

Decoupling social status and status certainty effects on health in macaques: a network approach.

BackgroundAlthough a wealth of literature points to the importance of social factors on health, a detailed understanding of the complex interplay between social and biological systems is lacking. Social status is one aspect of social life that is made up of multiple structural (humans: income, education; animals: mating system, dominance rank) and relational components (perceived social status, dominance interactions). In a nonhuman primate model we use novel network techniques to decouple two components of social status, dominance rank (a commonly used measure of social status in animal models) and dominance certainty (the relative certainty vs. ambiguity of an individual's status), allowing for a more complex examination of how social status impacts health.MethodsBehavioral observations were conducted on three outdoor captive groups of rhesus macaques (N = 252 subjects). Subjects' general physical health (diarrhea) was assessed twice weekly, and blood was drawn once to assess biomarkers of inflammation (interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP)).ResultsDominance rank alone did not fully account for the complex way that social status exerted its effect on health. Instead, dominance certainty modified the impact of rank on biomarkers of inflammation. Specifically, high-ranked animals with more ambiguous status relationships had higher levels of inflammation than low-ranked animals, whereas little effect of rank was seen for animals with more certain status relationships. The impact of status on physical health was more straightforward: individuals with more ambiguous status relationships had more frequent diarrhea; there was marginal evidence that high-ranked animals had less frequent diarrhea.DiscussionSocial status has a complex and multi-faceted impact on individual health. Our work suggests an important role of uncertainty in one's social status in status-health research. This work also suggests that in order to fully explore the mechanisms for how social life influences health, more complex metrics of social systems and their dynamics are needed

Effect of chicken bone extracts on metabolic and mitochondrial functions of K562 cell line

Background: Tetracyclines’ use in intensive animal farming has raised some concerns regarding the biosafety for humans. Increasing evidences have revealed the presence of these drugs in processed animal by-products, such as bone, throughout the food chain. A potential off-target of tetracyclines is the bacterial-like mitochondrial translational machinery, thereby causing proteostatic alterations in mitochondrial DNA-encoded components of the oxidative phosphorylation system. Methods: The Seahorse methodology, confocal microscopy imaging of mitochondrial potential and reactive oxygen species, and q-RT-PCR analysis of the expression of genes involved in mitochondrial biogenesis and mitophagy were carried out on human lymphoblast derived K562 cell line challenged with bone powder derived from chicken treated with or without oxytetracycline and pure oxytetracycline. Results: A complex dose-dependent profile was attained with a low dosage of bone powder extracts causing a metabolic adaptation hallmarked by stimulation of the mitochondrial respiration and enhanced expression of mitochondriogenic factors in particular in cells challenged with oxytetracycline-free bone extract. Conversely, a higher dosage of bone powder extracts, regardless of their source, caused a progressive inhibition of mitochondrial respiration and glycolysis, ultimately leading to cell death. No significant effects of the pure oxytetracycline were observed. Conclusion: Bone powder, regardless of chicken treatment, contains and releases factors/chemicals responsible for the observed effects on energy metabolism. Quantitative differential effects appear to depend on biochemical alterations in the bone matrix caused by antibiotics rather than antibiotics themselves