Botulinum Toxin for giant omphalocele abdominal wall reconstruction

Introduction The use of Botulinum Toxin A (BTA) has been shown to be safe and efficacious in neuromuscular blockade in both adult and pediatric patients. While BTA injections have been used safely in the pediatric population for a variety of medical conditions, its use in pediatric abdominal wall reconstruction has not been described. This report describes a unique surgical technique that will increase abdominal domain and allow for earlier closure of giant omphalocele defects. Case report A 33-week twin premie was born with a giant omphalocele. In an effort to achieve primary closure without the need for mesh, BTA injections were performed under ultrasound guidance two weeks prior to a planned closure. BTA injections included administration of 8 units at separate sites of the abdominal musculature bilaterally. After reduction, a component separation, and primary approximation of the fascial defect were achieved without signs of abdominal compartment syndrome. Conclusion BTA injection into the abdominal wall musculature provides a safe and effective mechanism to increase laxity of the abdominal wall musculature and decrease tension on the reconstruction for giant omphaloceles defects. The use of BTA may allow earlier repair in this subset of patients without the need for mesh

NF-κB: blending metabolism, immunity, and inflammation

The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic programs control inflammation, metabolism, and immunity and how improved knowledge of them may lead to better diagnostics and therapeutics for widespread human diseases

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB activation also contributes to the pathogenesis of some of the most common current threats to global human health, including chronic inflammatory diseases, autoimmune disorders, diabetes, vascular diseases and the majority of cancers. Accordingly, the NF-κB pathway is widely considered an attractive therapeutic target in a broad range of malignant and non-malignant diseases. Yet, despite the aggressive efforts by the pharmaceutical industry to develop a specific NF-κB inhibitor, none has been clinically approved, due to the dose-limiting toxicities associated with the global suppression of NF-κB. In this review, we summarise the main strategies historically adopted to therapeutically target the NF-κB pathway with an emphasis on oncology, and some of the emerging strategies and newer agents being developed to pharmacologically inhibit this pathway

Experimental investigation of unsteady flows at large incidence angles in a linear oscillating cascade

The aerodynamics of a cascade of airfoils oscillating in torsion about the midchord is investigated experimentally at a large mean incidence angle and, for reference, at a low mean incidence angle. The airfoil section is representative of a modern, low aspect ratio, fan blade tip section. Time-dependent airfoil surface pressure measurements were made for reduced frequencies up to 0.8 for out-of-phase oscillations at Mach numbers up to 0.8 and chordal incidence angles of 0 deg and 10 deg. For the 10 deg chordal incidence angle, a separation bubble formed at the leading edge of the suction surface. The separated flow field was found to have a dramatic effect on the chordwise distribution of the unsteady pressure. In this region, substantial deviations from the attached flow data were found with the deviations becoming less apparent in the aft region of the airfoil for all reduced frequencies. In particular, near the leading edge the separated flow had a strong destabilizing influence while the attached flow had a strong stabilizing influence

1-Butanol dehydration and oxidation over vanadium phosphate catalysts

The transformation of 1-butanol into either butenes or maleic anhydride was carried out both with and without oxygen, using V/P/O catalysts. With vanadyl pyrophosphate prepared by coprecipitation, at temperature lower than 240 ◦C and without oxygen, selectivity to butenes was higher than 90%, but a slow deactivation took place. At temperature higher than 300 ◦C and in the presence of air, maleic and phthalic anhydrides were the prevailing products, with selectivity of 60% and 14%, respectively. Catalytic performance was affected by crystallinity and acidity. αI-VOPO4 showed a poor performance in the absence of air, with a quick deactivation due to coke accumulation; but it displayed an excellent selectivity to butenes (close to 98%) at temperatures lower than 320 ◦C in the presence of air, with stable performance. At temperature higher than 360 ◦C, α I-VOPO4 was reduced to vanadyl pyrophosphate and catalyzed the direct oxidation of 1-butanol into maleic anhydride, but with 35% selectivit

Oscillating cascade aerodynamics at large mean incidence

The aerodynamics of a cascade of airfoils oscillating in torsion about the midchord is investigated experimentally at a large mean incidence angle and, for reference, at a low mean incidence angle. The airfoil section is representative of a modern, low aspect ratio, fan blade tip section. Time-dependent airfoil surface pressure measurements were made for reduced frequencies of up to 1.2 for out-of-phase oscillations at a Mach number of 0.5 and chordal incidence angles of 0 deg and 10 deg; the Reynolds number was 0.9 x l0(exp 6). For the 10 deg chordal incidence angle, a separation bubble formed at the leading edge of the suction surface. The separated flow field was found to have a dramatic effect on the chordwise distribution of the unsteady pressure. In this region, substantial deviations from the attached flow data were found with the deviations becoming less apparent in the aft region of the airfoil for all reduced frequencies. In particular, near the leading edge the separated flow had a strong destabilizing influence while the attached flow had a strong stabilizing influence

Intermittent Flow Regimes in a Transonic Fan Airfoil Cascade

A study was conducted in the NASA Glenn Research Center (NASA-GRC) linear cascade on the intermittent flow on the suction surface of an airfoil section from the tip region of a modern low aspect ratio fan blade. Experimental results revealed that, at a large incidence angle, a range of transonic inlet Mach numbers exist where the leading-edge shock-wave pattern was unstable. Flush-mounted, high-frequency response pressure transducers indicated large local jumps in the pressure in the leading edge area, which generates large intermittent loading on the blade leading edge. These measurements suggest that for an inlet Mach number between 0.9 and 1.0, the flow is bi-stable, randomly switching between subsonic and supersonic flows. Hence, it appears that the change in overall flow conditions in the transonic region is based on the rate of switching between two stable flow states rather than on the continuous increase of the flow velocity.To date, this flow behavior has only been observed in a linear transonic cascade. Further research is necessary to confirm this phenomenon occurs in actual transonic fans and is not the by-product of an endwall restricted linear cascade