Efficacy of different protein descriptors in predicting protein functional families

10.1186/1471-2105-8-300BMC Bioinformatics8-BBMI

Properties and Performance of Two Wide Field of View Cherenkov/Fluorescence Telescope Array Prototypes

A wide field of view Cherenkov/fluorescence telescope array is one of the main components of the Large High Altitude Air Shower Observatory project. To serve as Cherenkov and fluorescence detectors, a flexible and mobile design is adopted for easy reconfiguring of the telescope array. Two prototype telescopes have been constructed and successfully run at the site of the ARGO-YBJ experiment in Tibet. The features and performance of the telescopes are presented

Granular lightweight fill composed of sand and tire scrap

A granular geomaterial, known as sand-tire lightweight fill, was proposed by blending sand with disposed tire scrap in proportions. The geomaterial can be used as alternative backfill in many infrastructure works, where less overburdens and lateral loads are expected. The reuse of tire scraps may not only address growing environmental and economic concerns, but also help solve geotechnical problems associated with low soil shear strength. In this study, an experimental testing program was undertaken with the goal of evaluating the compression and shear behavior of the materials. Three tests were implemented, i.e., 1-D compression tests, direct shear tests and consolidated drained triaxial compression tests. A compression strain-load model was proposed to describe its compression behavior. Rebound-reload tests revealed that materials' plastic deformation was associated with the mixing ratios. The tire scrap content was found to influence the stress-strain and volumetric strain behavior of the mixtures. Mixtures underwent shear contraction during shearing processes, which is different from the shear dilation of compact sands. Effects of mixing ratios and stress conditions on shear deformation behaviors were also discussed.An Deng and Jin-Rong Fenghttp://ascelibrary.org/doi/abs/10.1061/41041%28348%291

The Superconductivity, Intragrain Penetration Depth and Meissner Effect of RuSr2(Gd,Ce)2Cu2O10+delta

The hole concentration (p)(delta), the transition temperature Tc, the intragrain penetration depth lambda, and the Meissner effect were measured for annealed RuSr2(Gd,Ce)2Cu2O10+delta samples. The intragrain superconducting transition temperature Tc} varied from 17 to 40 K while the p changed by only 0.03 holes/CuO2. The intragrain superfluid-density 1/lambda^2 and the diamagnetic drop of the field-cooled magnetization across Tc (the Meissner effect), however, increased more than 10 times. All of these findings are in disagreement with both the Tc vs. p and the Tc vs. 1/lambda^2 correlations proposed for homogeneous cuprates, but are in line with a possible phase-separation and the granularity associated with it.Comment: 7 pages, 6 figures, accepted for publication in Phys. Rev. B (May 2, 2002

Chapter VI: Follow-up after Revascularisation

AbstractStructured follow-up after revascularisation for chronic critical limb ischaemia (CLI) aims at sustained treatment success and continued best patient care. Thereby, efforts need to address three fundamental domains: (A) best medical therapy, both to protect the arterial reconstruction locally and to reduce atherosclerotic burden systemically; (B) surveillance of the arterial reconstruction; and (C) timely initiation of repeat interventions. As most CLI patients are elderly and frail, sustained resolution of CLI and preserved ambulatory capacity may decide over independent living and overall prognosis. Despite this importance, previous guidelines have largely ignored follow-up after CLI; arguably because of a striking lack of evidence and because of a widespread assumption that, in the context of CLI, efficacy of initial revascularisation will determine prognosis during the short remaining life expectancy. This chapter of the current CLI guidelines aims to challenge this disposition and to recommend evidentially best clinical practice by critically appraising available evidence in all of the above domains, including antiplatelet and antithrombotic therapy, clinical surveillance, use of duplex ultrasound, and indications for and preferred type of repeat interventions for failing and failed reconstructions. However, as corresponding studies are rarely performed among CLI patients specifically, evidence has to be consulted that derives from expanded patient populations. Therefore, most recommendations are based on extrapolations or subgroup analyses, which leads to an almost systematic degradation of their strength. Endovascular reconstruction and surgical bypass are considered separately, as are specific contexts such as diabetes or renal failure; and critical issues are highlighted throughout to inform future studies

The ARGO-YBJ Experiment Progresses and Future Extension

Gamma ray source detection above 30TeV is an encouraging approach for finding galactic cosmic ray origins. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulation for various types of sources above 100GeV. To target the goals, the ARGO-YBJ experiment has been established. Significant progresses have been made in the experiment. A large air shower detector array in an area of 1km2 is proposed to boost the sensitivity. Hybrid detection with multi-techniques will allow a good discrimination between different types of primary particles, including photons and protons, thus enable an energy spectrum measurement for individual specie. Fluorescence light detector array will extend the spectrum measurement above 100PeV where the second knee is located. An energy scale determined by balloon experiments at 10TeV will be propagated to ultra high energy cosmic ray experiments

High Altitude test of RPCs for the ARGO-YBJ experiment

A 50 m**2 RPC carpet was operated at the YangBaJing Cosmic Ray Laboratory (Tibet) located 4300 m a.s.l. The performance of RPCs in detecting Extensive Air Showers was studied. Efficiency and time resolution measurements at the pressure and temperature conditions typical of high mountain laboratories, are reported.Comment: 16 pages, 10 figures, submitted to Nucl. Instr. Met

A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses

We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants

Morphological segmentation analysis and texture-based support vector machines classification on mice liver fibrosis microscopic images

Background To reduce the intensity of the work of doctors, pre-classification work needs to be issued. In this paper, a novel and related liver microscopic image classification analysis method is proposed. Objective For quantitative analysis, segmentation is carried out to extract the quantitative information of special organisms in the image for further diagnosis, lesion localization, learning and treating anatomical abnormalities and computer-guided surgery. Methods in the current work, entropy based features of microscopic fibrosis mice’ liver images were analyzed using fuzzy c-cluster, k-means and watershed algorithms based on distance transformations and gradient. A morphological segmentation based on a local threshold was deployed to determine the fibrosis areas of images. Results the segmented target region using the proposed method achieved high effective microscopy fibrosis images segmenting of mice liver in terms of the running time, dice ratio and precision. The image classification experiments were conducted using Gray Level Co-occurrence Matrix (GLCM). The best classification model derived from the established characteristics was GLCM which performed the highest accuracy of classification using a developed Support Vector Machine (SVM). The training model using 11 features was found to be as accurate when only trained by 8 GLCMs. Conclusion The research illustrated the proposed method is a new feasible research approach for microscopy mice liver image segmentation and classification using intelligent image analysis techniques. It is also reported that the average computational time of the proposed approach was only 2.335 seconds, which outperformed other segmentation algorithms with 0.8125 dice ratio and 0.5253 precision

ARGO-YBJ constraints on very high energy emission from GRBs

The ARGO-YBJ (Astrophysical Radiation Ground-based Observatory at YangBaJing) experiment is designed for very high energy $\gamma$-astronomy and cosmic ray researches. Due to the full coverage of a large area ($5600 m^2$) with resistive plate chambers at a very high altitude (4300 m a.s.l.), the ARGO-YBJ detector is used to search for transient phenomena, such as Gamma-ray bursts (GRBs). Because the ARGO-YBJ detector has a large field of view ($\sim$2 sr) and is operated with a high duty cycle ($>$90%), it is well suited for GRB surveying and can be operated in searches for high energy GRBs following alarms set by satellite-borne observations at lower energies. In this paper, the sensitivity of the ARGO-YBJ detector for GRB detection is estimated. Upper limits to fluence with 99% confidence level for 26 GRBs inside the field of view from June 2006 to January 2009 are set in the two energy ranges 10$-$100 GeV and 10 GeV$-$1 TeV.Comment: accepted for publication in Astroparticle Physic