About a condition for blow up of solutions of Cauchy problem for a wave equation

`For the nonlinear wave equation in R-N x R+ (N greater than or equal to 2): partial derivative(2)u(x,t)/partial derivative(t)(2) - a partial derivative/partial derivative(xi)(a/(x) partial derivative/partial derivative(xi)u) = \u\(p-1 u,) in 1980 Kato proved the solution of Cauchy problem may blow rtp infinite time if 1 < p less than or equal to N + 1/N - 1. In the present work his result allowing 1 < p less than or equal to N + 3/N - 1 is improved by using different estimates

Global existence theory for the two-dimensional derivative Ginzburg-Landau equation

The generalized derivative Ginzburg-Landau equation in two spatial dimensions is discussed. The existence and uniqueness of global solution are obtained by Galerkin method and by a priori estimates on the solution in H-1-norm and H-2-norm

Temporal Model Adaptation for Person Re-Identification

Person re-identification is an open and challenging problem in computer vision. Majority of the efforts have been spent either to design the best feature representation or to learn the optimal matching metric. Most approaches have neglected the problem of adapting the selected features or the learned model over time. To address such a problem, we propose a temporal model adaptation scheme with human in the loop. We first introduce a similarity-dissimilarity learning method which can be trained in an incremental fashion by means of a stochastic alternating directions methods of multipliers optimization procedure. Then, to achieve temporal adaptation with limited human effort, we exploit a graph-based approach to present the user only the most informative probe-gallery matches that should be used to update the model. Results on three datasets have shown that our approach performs on par or even better than state-of-the-art approaches while reducing the manual pairwise labeling effort by about 80%

Characterizing Spatiotemporal Dynamics of Methane Emissions from Rice Paddies in Northeast China from 1990 to 2010

BACKGROUND: Rice paddies have been identified as major methane (CH(4)) source induced by human activities. As a major rice production region in Northern China, the rice paddies in the Three-Rivers Plain (TRP) have experienced large changes in spatial distribution over the recent 20 years (from 1990 to 2010). Consequently, accurate estimation and characterization of spatiotemporal patterns of CH₄ emissions from rice paddies has become an pressing issue for assessing the environmental impacts of agroecosystems, and further making GHG mitigation strategies at regional or global levels. METHODOLOGY/PRINCIPAL FINDINGS: Integrating remote sensing mapping with a process-based biogeochemistry model, Denitrification and Decomposition (DNDC), was utilized to quantify the regional CH(4) emissions from the entire rice paddies in study region. Based on site validation and sensitivity tests, geographic information system (GIS) databases with the spatially differentiated input information were constructed to drive DNDC upscaling for its regional simulations. Results showed that (1) The large change in total methane emission that occurred in 2000 and 2010 compared to 1990 is distributed to the explosive growth in amounts of rice planted; (2) the spatial variations in CH₄ fluxes in this study are mainly attributed to the most sensitive factor soil properties, i.e., soil clay fraction and soil organic carbon (SOC) content, and (3) the warming climate could enhance CH₄ emission in the cool paddies. CONCLUSIONS/SIGNIFICANCE: The study concluded that the introduction of remote sensing analysis into the DNDC upscaling has a great capability in timely quantifying the methane emissions from cool paddies with fast land use and cover changes. And also, it confirmed that the northern wetland agroecosystems made great contributions to global greenhouse gas inventory

Mild to moderate influenza A(H7N9) infections detected through China’s national influenza-like Illness sentinel surveillance system

Poster Session: News and Views from the H7N9 OutbreakBackground: The “clinical iceberg” phenomenon, where there are usually many more infected cases than is apparent symptomatically and even less so registered in the clinical setting, is a common feature of influenza disease. While this is certainly true for interpandemic influenza and the 2009 influenza A(H1N1) pandemic, this appeared to be less substantial for the Dutch A(H7N7) outbreak, and with A(H5N1) being an acknowledged exception. It remains unknown whether the “iceberg” applies to the influenza A(H7N9) virus that emerged in early 2013 in China. While the majority of laboratory-confirmed A(H7N9) cases presented with a severe clinical picture to a hospital, a small number of laboratory-confirmed cases have been identified through the sentinel influenza-like illness (ILI) surveillance system nationwide. The objective of our study was to describe the clinical characteristics of the complete case series of A(H7N9) cases as of May 15, 2013, that were identified through routine testing by the ILI sentinel surveillance system. Materials and Methods: ILI sentinel surveillance in China is conducted through a network of 554 hospitals across the country, with the total number of outpatient and/or emergency department visits and the number of patients fitting the WHO standard ILI case definition reported weekly online to the China CDC, and 10-15 nasopharyngeal swabs collected from ILI patients each week for routine laboratory testing and subtyping. All A(H7N9) cases detected through the ILI surveillance system by May 15, 2013, were identified by cross-referencing the laboratory-confirmed A(H7N9) line list with the routine sentinel ILI surveillance system. Demographic and epidemiologic data were extracted from field investigation records, and clinical and laboratory data were obtained from medical chart review. Results: Five (3.8%) of a total of 130 laboratory-confirmed influenza A(H7N9) cases reported as of May 28, 2013, were detected through the routine ILI surveillance system. Four (80%) of them were male. Mean age was 13 (range = 2-26) years and none had any underlying medical condition. Exposure history, geographic location and timing of symptom onset were otherwise similar to the general cohort of all laboratory-confirmed cases to date. All patients experienced only mild or moderate disease with an uneventful course of recovery. Among them three (60%) were managed only as outpatients and all quickly recovered after 3-5 days, with nasopharyngeal swabs tested positive for A(H7N9) only after their full recovery. Two patients (40%) were hospitalized for treatment. One was a 4-year-old child from Shanghai who presented initially as an outpatient with fever and mild rhinorrhea to a routine sentinel clinic, and was admitted on the next day for oseltamivir treatment after his nasopharyngeal swab was tested positive for A(H7N9). The other was a 26-year-old man from Jiangsu who presented initially with fever and productive cough to a sentinel clinic, being given ceftazidime without improvement. He was admitted 4 days later with radiologic evidence of left-sided pneumonia, and started on oseltamivir and moxifloxacin. Both remained clinically stable with quick resolution of symptoms within 10 days. Conclusions: Our complete case series of A(H7N9) cases detected through the routine ILI surveillance system provide contrasting clinical presentations to the generally much more severe clinical picture of the majority of laboratory-confirmed A(H7N9) cases detected otherwise. Our findings provide indirect evidence of a substantial proportion of mild disease and support the existence of a “clinical iceberg” phenomenon in influenza A(H7N9) infections. For the clinician, our findings reinforce vigilance to the diverse presentation that can be associated with influenza A(H7N9) virus infections. Our results also suggest that large-scale community surveillance networks can be useful as a population-based sampling tool to enhance understanding of the full spectrum of disease, especially in the early phase of an evolving epidemic.published_or_final_versio

Detection of mild to moderate influenza A/H7N9 infection by China's national sentinel surveillance system for influenza-like illness: case series

published_or_final_versio

Illegal births and legal abortions – the case of China

BACKGROUND: China has a national policy regulating the number of children that a woman is allowed to have. The central concept at the individual level application is "illegal pregnancy". The purpose of this article is to describe and problematicize the concept of illegal pregnancy and its use in practice. METHODS: Original texts and previous published and unpublished reports and statistics were used. RESULTS: By 1979 the Chinese population policy was clearly a policy of controlling population growth. For a pregnancy to be legal, it has to be defined as such according to the family-level eligibility rules, and in some places it has to be within the local quota. Enforcement of the policy has been pursued via the State Family Planning (FP) Commission and the Communist Party (CP), both of which have a functioning vertical structure down to the lowest administrative units. There are various incentives and disincentives for families to follow the policy. An extensive system has been created to keep the contraceptive use and pregnancy status of all married women at reproductive age under constant surveillance. In the early 1990s FP and CP officials were made personally responsible for meeting population targets. Since 1979, abortion has been available on request, and the ratio of legal abortions to birth increased in the 1980s and declined in the 1990s. Similar to what happens in other Asian countries with low fertility rates and higher esteem for boys, both national- and local-level data show that an unnaturally greater number of boys than girls are registered as having been born. CONCLUSION: Defining a pregnancy as "illegal" and carrying out the surveillance of individual women are phenomena unique in China, but this does not apply to other features of the policy. The moral judgment concerning the policy depends on the basic question of whether reproduction should be considered as an individual or social decision

A web-based appointment system to reduce waiting for outpatients: A retrospective study

<p>Abstract</p> <p>Background</p> <p>Long waiting times for registration to see a doctor is problematic in China, especially in tertiary hospitals. To address this issue, a web-based appointment system was developed for the Xijing hospital. The aim of this study was to investigate the efficacy of the web-based appointment system in the registration service for outpatients.</p> <p>Methods</p> <p>Data from the web-based appointment system in Xijing hospital from January to December 2010 were collected using a stratified random sampling method, from which participants were randomly selected for a telephone interview asking for detailed information on using the system. Patients who registered through registration windows were randomly selected as a comparison group, and completed a questionnaire on-site.</p> <p>Results</p> <p>A total of 5641 patients using the online booking service were available for data analysis. Of them, 500 were randomly selected, and 369 (73.8%) completed a telephone interview. Of the 500 patients using the usual queuing method who were randomly selected for inclusion in the study, responses were obtained from 463, a response rate of 92.6%. Between the two registration methods, there were significant differences in age, degree of satisfaction, and total waiting time (<it>P </it>< 0.001). However, gender, urban residence, and valid waiting time showed no significant differences (<it>P </it>> 0.05). Being ignorant of online registration, not trusting the internet, and a lack of ability to use a computer were three main reasons given for not using the web-based appointment system. The overall proportion of non-attendance was 14.4% for those using the web-based appointment system, and the non-attendance rate was significantly different among different hospital departments, day of the week, and time of the day (<it>P </it>< 0.001).</p> <p>Conclusion</p> <p>Compared to the usual queuing method, the web-based appointment system could significantly increase patient's satisfaction with registration and reduce total waiting time effectively. However, further improvements are needed for broad use of the system.</p

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Oxidative stress reflects an imbalance between reactive oxygen species (ROS) and antioxidants, which has been reported as an early unifying event in the development and progression of various diseases and as a direct and mechanistic indicator of treatment response. However, highly reactive and short-lived nature of ROS and antioxidant limited conventional detection agents, which are influenced by many interfering factors. Here, we present a two-photon sensing platform for in vivo dual imaging of oxidative stress at the single cell-level resolution. This sensing platform consists of three probes, which combine the turn-on fluorescent transition-metal complex with different specific responsive groups for glutathione (GSH), hydrogen peroxide (H2O2) and hypochlorous acid (HOCl). By combining fluorescence intensity imaging and fluorescence lifetime imaging, these probes totally remove any possibility of crosstalk from in vivo environmental or instrumental factors, and enable accurate localization and measurement of the changes in ROS and GSH within the liver. This precedes changes in conventional biochemical and histological assessments in two distinct experimental murine models of liver injury. The ability to monitor real-time cellular oxidative stress with dual-modality imaging has significant implications for high-accurate, spatially configured and quantitative assessment of metabolic status and drug response

Biomechanical analysis of the lumbar spine on facet joint force and intradiscal pressure - a finite element study

<p>Abstract</p> <p>Background</p> <p>Finite element analysis results will show significant differences if the model used is performed under various material properties, geometries, loading modes or other conditions. This study adopted an FE model, taking into account the possible asymmetry inherently existing in the spine with respect to the sagittal plane, with a more geometrically realistic outline to analyze and compare the biomechanical behaviour of the lumbar spine with regard to the facet force and intradiscal pressure, which are associated with low back pain symptoms and other spinal disorders. Dealing carefully with the contact surfaces of the facet joints at various levels of the lumbar spine can potentially help us further ascertain physiological behaviour concerning the frictional effects of facet joints under separate loadings or the responses to the compressive loads in the discs.</p> <p>Methods</p> <p>A lumbar spine model was constructed from processes including smoothing the bony outline of each scan image, stacking the boundary lines into a smooth surface model, and subsequent further processing in order to conform with the purpose of effective finite element analysis performance. For simplicity, most spinal components were modelled as isotropic and linear materials with the exception of spinal ligaments (bilinear). The contact behaviour of the facet joints and changes of the intradiscal pressure with different postures were analyzed.</p> <p>Results</p> <p>The results revealed that asymmetric responses of the facet joint forces exist in various postures and that such effect is amplified with larger loadings. In axial rotation, the facet joint forces were relatively larger in the contralateral facet joints than in the ipsilateral ones at the same level. Although the effect of the preloads on facet joint forces was not apparent, intradiscal pressure did increase with preload, and its magnitude increased more markedly in flexion than in extension and axial rotation.</p> <p>Conclusions</p> <p>Disc pressures showed a significant increase with preload and changed more noticeably in flexion than in extension or in axial rotation. Compared with the applied preloads, the postures played a more important role, especially in axial rotation; the facet joint forces were increased in the contralateral facet joints as compared to the ipsilateral ones at the same level of the lumbar spine.</p