What Makes it Difficult to Understand a Scientific Literature?

In the artificial intelligence area, one of the ultimate goals is to make computers understand human language and offer assistance. In order to achieve this ideal, researchers of computer science have put forward a lot of models and algorithms attempting at enabling the machine to analyze and process human natural language on different levels of semantics. Although recent progress in this field offers much hope, we still have to ask whether current research can provide assistance that people really desire in reading and comprehension. To this end, we conducted a reading comprehension test on two scientific papers which are written in different styles. We use the semantic link models to analyze the understanding obstacles that people will face in the process of reading and figure out what makes it difficult for human to understand a scientific literature. Through such analysis, we summarized some characteristics and problems which are reflected by people with different levels of knowledge on the comprehension of difficult science and technology literature, which can be modeled in semantic link network. We believe that these characteristics and problems will help us re-examine the existing machine models and are helpful in the designing of new one.Comment: Accepted by SKG201

The molecular and phenotypic spectrum of CLCN4-related epilepsy

Objective This study was undertaken to expand the phenotypic and genetic spectrum of CLCN4-related epilepsy and to investigate genotype–phenotype correlations. Methods We systematically reviewed the phenotypic and genetic spectrum of newly diagnosed and previously reported patients with CLCN4-related epilepsy. Three novel variants identified in four patients reported in this study were evaluated through in silico prediction and functional analysis by Western blot, immunofluorescence, and electrophysiological measurements. Results Epilepsy was diagnosed in 54.55% (24/44) of individuals with CLCN4-related disorders and was drug-resistant in most cases. Of 24 patients, 15 had epileptic encephalopathy and four died at an early age; 69.57% of patients had seizure onset within the first year of life. Myoclonic seizures are the most common seizure type, and 56.25% of patients presented multiple seizure types. Notably, seizure outcome was favorable in individuals with only one seizure type. All patients showed intellectual disability, which was severe in 65.22% of patients. Additional common features included language delay, behavioral disorders, and dysmorphic features. Five patients benefitted from treatment with lamotrigine. Most variants, which were mainly missense (79.17%), were inherited (70.83%). Whereas frameshift, intragenic deletion, or inherited variants were associated with milder phenotypes, missense or de novo variants led to more severe phenotypes. All evaluated CLCN4 variants resulted in loss of function with reduced ClC-4 currents. Nonetheless, genotype–phenotype relationships for CLCN4-related epilepsy are not straightforward, as phenotypic variability was observed in recurrent variants and within single families. Significance Pathogenic CLCN4 variants contribute significantly to the genetic etiology of epilepsy. The phenotypic spectrum of CLCN4-related epilepsy includes drug-resistant seizures, cognitive and language impairment, behavioral disorders, and congenital anomalies. Notably, the mutation type and the number of seizure types correlate with the severity of the phenotype, suggesting its use for clinical prognosis. Lamotrigine can be considered a therapeutic option

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

ObjectiveTo test the feasibility and reliability of intracranial electrophysiological recordings in an acute status epilepticus model on laboratory swine.MethodIntrahippocampal injection of kainic acid (KA) was performed on 17 male Bama pigs (Sus scrofa domestica) weighing between 25 and 35 kg. Two stereoelectroencephalography (SEEG) electrodes with a total of 16 channels were implanted bilaterally along the sensorimotor cortex to the hippocampus. Brain electrical activity was recorded 2 h daily for 9–28 days. Three KA dosages were tested to evaluate the quantities capable of evoking status epilepticus. Local field potentials (LFPs) were recorded and compared before and after the KA injection. We quantified the epileptic patterns, including the interictal spikes, seizures, and high-frequency oscillations (HFOs), up to 4 weeks after the KA injection. Test–retest reliability using intraclass correlation coefficients (ICCs) were performed on interictal HFO rates to evaluate the recording stability of this model.ResultsThe KA dosage test suggested that a 10 μl (1.0 μg/μl) intrahippocampal injection could successfully evoke status epilepticus lasting from 4 to 12 h. At this dosage, eight pigs (50% of total) had prolonged epileptic events (tonic-chronic seizures + interictal spikes n = 5, interictal spikes alone n = 3) in the later 4 weeks of the video-SEEG recording period. Four pigs (25% of total) had no epileptic activities, and another four (25%) had lost the cap or did not complete the experiments. Animals that showed epileptiform events were grouped as E + (n = 8) and the four animals showing no signs of epileptic events were grouped as E– (n = 4). A total of 46 electrophysiological seizures were captured in the 4-week post-KA period from 4 E + animals, with the earliest onset on day 9. The seizure durations ranged from 12 to 45 s. A significant increase of hippocampal HFOs rate (num/min) was observed in the E+ group during the post-KA period (weeks 1, 2,4, p < 0.05) compared to the baseline. But the E-showed no change or a decrease (in week 2, p = 0.43) compared to their baseline rate. The between-group comparison showed much higher HFO rates in E + vs. E – (F = 35, p < 0.01). The high ICC value [ICC (1, k) = 0.81, p < 0.05] quantified from the HFO rate suggested that this model had a stable measurement of HFOs during the four-week post-KA periods.SignificanceThis study measured intracranial electrophysiological activity in a swine model of KA-induced mesial temporal lobe epilepsy (mTLE). Using the clinical SEEG electrode, we distinguished abnormal EEG patterns in the swine brain. The high test–retest reliability of HFO rates in the post-KA period suggests the utility of this model for studying mechanisms of epileptogenesis. The use of swine may provide satisfactory translational value for clinical epilepsy research

Chinese Cerebrovascular Neurosurgery Society and Chinese Interventional & Hybrid Operation Society, of Chinese Stroke Association Clinical Practice Guidelines for Management of Brain Arteriovenous Malformations in Eloquent Areas

Aim: The aim of this guideline is to present current and comprehensive recommendations for the management of brain arteriovenous malformations (bAVMs) located in eloquent areas.Methods: An extended literature search on MEDLINE was performed between Jan 1970 and May 2020. Eloquence-related literature was further screened and interpreted in different subcategories of this guideline. The writing group discussed narrative text and recommendations through group meetings and online video conferences. Recommendations followed the Applying Classification of Recommendations and Level of Evidence proposed by the American Heart Association/American Stroke Association. Prerelease review of the draft guideline was performed by four expert peer reviewers and by the members of Chinese Stroke Association.Results: In total, 809 out of 2,493 publications were identified to be related to eloquent structure or neurological functions of bAVMs. Three-hundred and forty-one publications were comprehensively interpreted and cited by this guideline. Evidence-based guidelines were presented for the clinical evaluation and treatment of bAVMs with eloquence involved. Topics focused on neuroanatomy of activated eloquent structure, functional neuroimaging, neurological assessment, indication, and recommendations of different therapeutic managements. Fifty-nine recommendations were summarized, including 20 in Class I, 30 in Class IIa, 9 in Class IIb, and 2 in Class III.Conclusions: The management of eloquent bAVMs remains challenging. With the evolutionary understanding of eloquent areas, the guideline highlights the assessment of eloquent bAVMs, and a strategy for decision-making in the management of eloquent bAVMs

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

The DNA methyltransferase Dnmt3a has high expression in terminally differentiated macrophages; however, its role in innate immunity remains unknown. Here we report that deficiency in Dnmt3a selectively impaired the production of type I interferons triggered by pattern-recognition receptors (PRRs), but not that of the proinflammatory cytokines TNF and IL-6. Dnmt3a-deficient mice exhibited enhanced susceptibility to viral challenge. Dnmt3a did not directly regulate the transcription of genes encoding type I interferons; instead, it increased the production of type I interferons through an epigenetic mechanism by maintaining high expression of the histone deacetylase HDAC9. In turn, HDAC9 directly maintained the deacetylation status of the key PRR signaling molecule TBK1 and enhanced its kinase activity. Our data add mechanistic insight into the crosstalk between epigenetic modifications and post-translational modifications in the regulation of PRR signaling and activation of antiviral innate immune responses

Near-Optimal Active Learning for Multilingual Grapheme-to-Phoneme Conversion

The construction of pronunciation dictionaries relies on high-quality and extensive training data in data-driven way. However, the manual annotation of corpus for this purpose is both costly and time consuming, especially for low-resource languages that lack sufficient data and resources. A multilingual pronunciation dictionary includes some common phonemes or phonetic units, which means that these phonemes or units have similarities in the pronunciation of different languages and can be used in the construction process of pronunciation dictionaries for low-resource languages. By using a multilingual pronunciation dictionary, knowledge can be shared among different languages, thus improving the quality and accuracy of pronunciation dictionaries for low-resource languages. In this paper, we propose using shared articulatory features among multiple languages to construct a universal phoneme set, which is then used to label words for multiple languages. To achieve this, we first developed a grapheme−phoneme (G2P) model based on an encoder−decoder deep neural network. We then adopted a near-optimal active learning method in the process of building the pronunciation dictionary to select informative samples from a large, unlabeled corpus and had them labeled by experts. Our experiments demonstrate that this method selected about 1/5 of the unlabeled data and achieved an even higher conversion accuracy than the results of the large data training method. By selectively labeling samples with a high uncertainty in the model, while avoiding labeling samples that were accurately predicted by the current model, our method greatly enhances the efficiency of pronunciation dictionary construction

Exploring the Potential of Unmanned Aerial Vehicle (UAV) Remote Sensing for Mapping Plucking Area of Tea Plantations

Mapping plucking areas of tea plantations is essential for tea plantation management and production estimation. However, on-ground survey methods are time-consuming and labor-intensive, and satellite-based remotely sensed data are not fine enough for plucking area mapping that is 0.5–1.5 m in width. Unmanned aerial vehicles (UAV) remote sensing can provide an alternative. This paper explores the potential of using UAV-derived remotely sensed data for identifying plucking areas of tea plantations. In particular, four classification models were built based on different UAV data (optical imagery, digital aerial photogrammetry, and lidar data). The results indicated that the integration of optical imagery and lidar data produced the highest overall accuracy using the random forest algorithm (94.39%), while the digital aerial photogrammetry data could be an alternative to lidar point clouds with only a ~3% accuracy loss. The plucking area of tea plantations in the Huashan Tea Garden was accurately measured for the first time with a total area of 6.41 ha, which accounts for 57.47% of the tea garden land. The most important features required for tea plantation mapping were the canopy height, variances of heights, blue band, and red band. Furthermore, a cost–benefit analysis was conducted. The novelty of this study is that it is the first specific exploration of UAV remote sensing in mapping plucking areas of tea plantations, demonstrating it to be an accurate and cost-effective method, and hence represents an advance in remote sensing of tea plantations

Surgical resection of pulmonary metastases from colorectal cancer: 11 years of experiences.

To analyze the benefits and prognostic factors after surgical resection of pulmonary metastases from colorectal cancer (CRC).From Jan. 2004 to Jan. 2015, continuous 88 cases diagnosed with pulmonary metastases from CRC, including 15 cases of synchronous metastases and 73 metachronous metastases, were analyzed in the retrospective study.All of these 88 cases underwent curative pulmonary resection including 8 cases of simultaneous surgery. The one-year, three-year and five-year survival of the 88 cases were 93.4%, 60.2% and 35.7%, respectively. 63 patients just have one metastasis, and 25 patients have more than one metastasis. Additionally, the one-year, three-year and five-year survival was 98.1%, 70.2% and 40.3% respectively in one metastasis group, while 80.1%, 37.9% and 22.5% respectively in more than one metastasis group (p = 0.003). DFS of 37 metachronous metastases were equal or greater than 18 months, and DFS of 36 metachronous metastases were less than 18 months. The one-year, three-year and five-year survival was 97.8%, 77.9% and 41.4% respectively in the DFS≥18 month group, while 88.2%, 44.6% and 28.1% respectively in the DFS<18 month group (p = 0.01).Surgical resection of pulmonary metastases from colorectal cancer can improve survival rate in selected patients. It seems that the number of metastases is an independence prognostic factor in surgical treatment. Furthermore, longer DFI implies longer survival for resectable CRC pulmonary metastases

Antihypertensive treatment and risk factors for syncope in asymptomatic aortic stenosis patients with hypertension

Background Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis(AS) is scarce. Objectives Given the paucity of data on the relationship between syncope and antihypertensive treatment in aortic stenosis. This study sought to investigate this association in patients admitted to our hospital. Methods A total of 158 patients with asymptomatic moderate or severe aortic stenosis were analyzed. Follow-up was conducted by clinic visit, telephone contact, or review of electronic medical records. Outcomes were syncope. Results Hypertension were documented in 90 of the 158 patients with moderate or severe AS, and 77 of them received antihypertensive medications. During an average 28 months follow-up period, the occurrence of syncope was observed in 13 patients. Among them, 8 were in antihypertensive group (n = 77) and 5 in normotensive group (n = 68). There was no significant difference in incidence of syncope between the two groups. Patients with treated hypertension and syncope had a lower stroke volume index (SVi), a higher valve arterial impedance (ZVA), a smaller SAC than those without. Kaplan-Meier analysis showed that there was no significant difference in syncope cumulative incidence between antihypertensive group and normotensive group (log rank P = .478). Multivariate cox regression analysis showed that both ZVA (hazard ratio:19.006, 95% confidence interval: 4.664 to77.448;P = .002) and LVMI (hazard ratio:1.484, 95% confidence interval: 1.427 to 5.157;P = .016) were associated with development of syncope, whereas hypertension were not related independently to syncope (hazard ratio:0.935, 95% confidence interval: 0.786 to3.173; P = .869). Conclusions In patients with moderate or severe AS, concomitant hypertension, and antihypertensive treatment didn’t increase the occurrence of syncope, whereas higher ZVA was independently associated with greater risk of syncope