Igualdad de los cariotipos ante la Ley

El objetivo general de esta investigación es hacer visible la multiplicidad de cuerpos intersexuales y su exclusión del mundo de lo “natural”, para cuestionar el binario hegemónico heteronormado y las intervenciones normalizadoras cosméticas. Utilizo los registros biológicos jurisprudenciales de Argentina y Colombia entre los años 1994 y 2015.En esta investigación, doy cuenta de la diversidad sexual desde la biología, mostrando, a partir de la noción de cariotipo, la existencia de múltiples sexos diferentes al binario hembra-macho. En esta ocasión, profundizo mi tesis doctoral en la que defendí la posibilidad de que la   intersexualidad sea considerada una postura identitaria, para lo cual, despliego las diferentes formas biológicas de intersexualidad que aparecen en la jurisprudencia.Me interesa evidenciar que existen tantos sexos como cariotipos humanos viables, con cuerpos, genitalidades y erotismos propios, que exceden ampliamente los límites impuestos por el paradigma heteronormativo. Las nociones de diversidad, igualdad y autonomía personal son los cimientos de mi propuesta.AbstractThe general objective of this research is to make visible the multiplicity of intersexual bodies and their exclusion from "natural" world, to put in question the heteronormative hegemonic binary and cosmetic normalizing interventions. I use the biological records of jurisprudence of Argentina and Colombia between the years 1994-2015.In this research, I show the sexual diversity from biology showing, from the notion of karyotype, the existence of multiple sexes different from the male and female binary. Now I deepen my doctoral thesis in which I defended the possibility of intersexuality being considered an identity stance, for which I deployed the different biological forms of intersexuality that appear in jurisprudence.I am interested in evidencing that there are as many sexes as viable human karyotypes with their own bodies, genitalities and erotisms that far exceed the limits imposed by the heteronormative, strengthening the notions of diversity, equality, and personal autonomy.ResumoO objetivo geral desta pesquisa é fazer visível a multiplicidade de corpos intersexuais e sua exclusão do mundo do “natural” para questionar o binário hegemônico heteronormado e as intervenções normalizadoras cosméticas. Utilizo os registros biológicos jurisprudenciais da Argentina e da Colômbia entre os anos 1994-2015.Nesta investigação apresento a diversidade sexual desde a biologia mostrando, a partir da noção de cariótipo, a existência de múltiples sexos diferentes ao binário fêmea-macho. Agora aprofundo minha tese doutoral na qual defendi a possibilidade de que a intersexualidade seja considerada uma posturaidentitária, para isso, desdobro as diferentes formas biológicas de intersexualidade que aparecem na jurisprudência.Meu interesse é evidenciar que existem tantos sexos como cariótipos humanos viáveis com corpos, genitalidades e erotismos próprios que excedem amplamente os limitem impostos pelo paradigma heteronormativo.     Palabras clave:Igualdad – cariotipo- autonomía personal Key words:Equality- karyotype - personal autonomy Palavras chave:Igualdade – cariótipo - autonomia pessoa

Informe ampliado: efectos socioeconómicos y culturales de la pandemia COVID-19 y del aislamiento social, preventivo y obligatorio en los Pueblos Indígenas en Argentina -Segunda etapa, junio 2020-

A partir de la pandemia generada por el COVID-19, con el consiguiente Aislamiento Social Preventivo y Obligatorio (ASPO) dispuesto a partir del 20/03/2020 y demás acciones implementadas desde el Estado nacional argentino, un conjunto de equipos, instituciones, investigadores, becaries y tesistas de diferentes ámbitos del país, nos agrupamos con el objetivo de elaborar un informe acerca de las consecuencias e impactos socioeconómicos y culturales que atraviesan los pueblos indígenas con los que trabajamos en las regiones Metropolitana, Pampeana, Noroeste, Noreste, Cuyo y Patagonia. En una primera instancia, más de 30 autores, participaron en la elaboración de un informe (1er etapa) presentado el 15 de abril de 20201 . En esta segunda etapa, con más de 100 integrantes de diferentes ámbitos académicos del país, se amplió lo abordado a partir de la actualización y profundización de las problemáticas y situaciones que experimentan un conjunto de diversas comunidades y pueblos originarios –qom, mbya, moqoit, mapuche, guaraní, tupí guaraní, avá guaraní, kolla, diaguita, diaguita-calchaquí, wichí, huarpe, quechua, aymara, nivaclé, tonokote, omaguaca, tastil, günün a küna, comechingón, comechingón-camiare, ocloya, iogys, chané, tapiete, chorote, chulupi, sanavirón, ranquel, wehnayek, atacama, lule, quilmes, mapuche-pehuenches, tehuelches, mapuche-tehuelches, selk‘nam, haush y selk‘nam-haush-.Valdata, Marcela. Universidad Nacional de Rosario. Facultad de Humanidades y Artes. Centro de Estudios Aplicados a Problemáticas Socioculturales. Rosario; Argentin

Bortezomib-thalidomide-dexamethasone is superior to thalidomide- dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma

In a randomized, phase 3 study, superior complete/near-complete response (CR/nCR) rates and extended progression-free survival were demonstrated with bortezomib-thalidomide-dexamethasone (VTD) versus thalidomide-dexamethasone (TD) as induction therapy before, and consolidation after, double autologous stem cell transplantation for newly diagnosed myeloma patients (intention-to-treat analysis; VTD, n = 236; TD, n = 238). This per-protocol analysis (VTD, n = 160; TD, n = 161) specifically assessed the efficacy and safety of consolidation with VTD or TD. Before starting consolidation, CR/nCR rates were not significantly different in the VTD (63.1%) and TD arms (54.7%). After consolidation, CR (60.6% vs 46.6%) and CR/nCR (73.1% vs 60.9%) rates were significantly higher for VTD-treated versus TD-treated patients. VTD consolidation significantly increased CR and CR/nCR rates, but TD did not (McNemar test). With a median follow-up of 30.4 months from start of consolidation, 3-year progression-free survival was significantly longer for the VTD group (60% vs 48% for TD). Grade 2 or 3 peripheral neuropathy (8.1% vs 2.4%) was more frequent with VTD (grade 3, 0.6%) versus TD consolidation. The superior efficacy of VTD versus TD as induction was retained despite readministration as consolidation therapy after double autologous transplantation. VTD consolidation therapy significantly contributed to improved clinical outcomes observed for patients randomly assigned to the VTD arm of the study. The study is registered at www.clinicaltrials.gov as #NCT01134484. \ua9 2012 by The American Society of Hematology

Report from Working Group 3: Beyond the Standard Model physics at the HL-LHC and HE-LHC

This is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3$ ab$^{-1}$ of data taken at a centre-of-mass energy of 14 TeV, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15$ ab$^{-1}$ of data at a centre-of-mass energy of 27 TeV. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will, generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics

Report from Working Group 3 : Beyond the Standard Model Physics at the HL-LHC and HE-LHC

CERN Yellow Reports: Monographs, vol 7 (2019)Contribution to: HL/HE-LHC WorkshopThis is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3$ ab$^{-1}$ of data taken at a centre-of-mass energy of 14 TeV, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15$ ab$^{-1}$ of data at a centre-of-mass energy of 27 TeV. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will, generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics