Communicating World Heritage to global audiences of travelers. ECREA 2018 special panel report

Information and Communication Technologies (ICTs) might play a key role in communicating heritage to global audiences of travelers, thanks to their pervasiveness and ease of use. The contributors to this panel discussed this issue, considering cases that helped to point out some major topics, in particular: the use of mobile applications to support travelers’ planning and experience on site, cultural localization of online information to widen access to heritage understanding, online  communication planning to closely connect locals and tourists with heritage, ICTs to develop new approaches to heritage destination stewardship

Adaptation to G93A superoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis. The role of glutathione

Motor neuron degeneration in amyotrophic lateral sclerosis involves oxidative damage. Glutathione (GSH) is critical as an antioxidant and a redox modulator. We used a motor neuronal cell line (NSC-34) to investigate whether wild-type and familial amyotrophic lateral sclerosis-linked G93A mutant Cu,Zn superoxide dismutase (wt ⁄G93ASOD1) modified the GSH pool and glutamate cysteine ligase (GCL), the rate-limiting enzyme for GSH synthesis. We studied the effect of various G93ASOD1 levels and exposure times. Mutant Cu,Zn superoxide dismutase induced an adaptive process involving the upregulation of GSH synthesis, even at very low expression levels. However, cells with a high level of G93ASOD1 cultured for 10 weeks showed GSH depletion and a decrease in expression of the modulatory subunit of GCL. These cells also had lower levels of GSH and GCL activity was not induced after treatment with the pro-oxidant tertbutylhydroquinone. Cells with a low level of G93ASOD1 maintained higher GSH levels and GCL activity, showing that the exposure time and the level of the mutant protein modulate GSH synthesis. We conclude that failure of the regulation of the GSH pathway caused by G93ASOD1 may contribute to motor neuron vulnerability and we identify this pathway as a target for therapeutic intervention

Polyethylene glycol-assisted hydro-solvothermal growth of anisotropic magnetic iron oxides: The role of mixed environment conditions

In this study, an alternative mixed hydro-solvothermal route has been investigated for the synthesis of magnetic iron oxide nanoparticles with anisotropic shape. The synthesis was performed at mild conditions (150 ◦C) in a water/2-propanol environment, using poly(ethylene glycol) (PEG400) as structure directing agent, sodium thiosulfate as reducing agent, and NaOH as precipitating agent. The resulting systems were characterized by combining morphological, structural, and magnetic techniques. Experimental results clearly demonstrate that magnetite/maghemite nanorods are preferentially obtained in water/PEG400 environment, whereas 2-propanol/PEG400 environment promotes the growth of magnetite/maghemite polyhedral systems. Interestingly, synthesis performed in a mixed hydro-solvothermal (i.e., water/2-propanol) environment favors the preferential growth of hematite phase

Delayed, severe thrombocytemia after abciximab infusion for primary angioplasty in acute coronary syndromes: Moving between systemic bleeding and stent thrombosis

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