Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis

Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis

A Brief History of Singlefold Diophantine Definitions

Consider an (m + 1)-ary relation R over the set N of natural numbers. Does there exist an arithmetical formula ZΘ(a0, . . . , am, x1, . . . , xK), not involving universal quantifiers, negation, or implication, such that the representation and univocity conditions, viz., (Formula Presented) are met by each tuple (Formula Presented). A priori, the answer may depend on the richness of the language of arithmetic: Even if solely addition and multiplication operators (along with the equality relator and with positive integer constants) are adopted as primitive symbols of the arithmetical signature, the graph R of any primitive recursive function is representable; but can representability be reconciled with univocity without calling into play one extra operator designating either the dyadic operation [b, n]↠ b n or just the monadic function n ↠ b n associated with a fixed integer b > 1? As a preparatory step toward a hoped-for positive answer to this question, one may consider replacing the exponentiation operator by a dyadic relator designating an exponential-growth relation (a notion made explicit by Julia Bowman Robinson in 1952). We will discuss the said univocity, aka ‘single-fold-ness’, issue-first raised by Yuri V. Matiyasevich in 1974-, framing it in historical context. © 2023 Copyright for this paper by its authors

The Automation of Syllogistic II. Optimization and Complexity Issues

In the first paper of this series it was shown that any unquantified formula p in the collection MLSSF (multilevel syllogistic extended with the singleton operator and the predicate Finite) can be decomposed as a disjunction of set-theoretic formulae called syllogistic schemes. The syllogistic schemes are satisfiable and no two of them have a model in common, therefore the previous result already implied the decidability of the class MLSSF by simply checking if the set of syllogistic schemes associated with the given formula is empty. In the first section of this paper a new and improved searching algorithm for syllogistic schemes is introduced, based on a proof of existence of a 'minimum effort' scheme for any given satisfiable formula in MLSF. The algorithm addressed above can be piloted quite effectively even though it involves backtracking. In the second part of the paper, complexity issues are studied by showing that the class of ( 00)o1-simple prenex formulae (an extension of MLS) has a decision problem which is NP-complete. The decision algorithm that proves the membership of this decision problem to NP can be seen as a different decision algorithm for ML

Continued Hereditarily Finite Set-Approximations

We study an encoding RA that assigns a real number to each hereditarily finite set, in a broad sense. In particular, we investigate whether the map RA can be used to produce codes that approximate any positive real number to arbitrary precision, in a way that is related to continued fractions. This is an interesting question because it connects the theory of hereditarily finite sets to the theory of real numbers and continued fractions, which have important applications in number theory, analysis, and other fields

cranial nerve abnormalities in oculo auriculo vertebral spectrum

BACKGROUND AND PURPOSE: Cranial nerve abnormalities might be observed in hemifacial microsomia and microtia (oculo-auriculo-vertebral spectrum), but the rate, features, and relationship with functional impairment or phenotype severity have not yet been defined. This study aimed at investigating absence/asymmetry, abnormal origin, morphology and course of cranial nerves, and presence/asymmetry of the foramen ovale and inferior alveolar nerve canal in a cohort of oculo-auriculo-vertebral spectrum patients. MATERIALS AND METHODS: Twenty-nine patients with oculo-auriculo-vertebral spectrum (mean age, 7 years; age range, 0.2–31 years; 12 females) underwent brain MR imaging, CT, and neurologic evaluation; 19 patients had a more severe phenotype (Goldenhar syndrome). RESULTS: Cranial nerve abnormalities were detected only in patients with Goldenhar syndrome (17/19, bilaterally in 8) and were involved the second (4/19), third (1/18), fifth (11/19), sixth (8/16), seventh (11/18), and eighth (8/18) cranial nerves. Multiple cranial nerve abnormalities were common (11/17). Eleven patients showed bone foramina abnormalities. Trigeminal and facial nerve dysfunctions were common (44% and 58%, respectively), especially in patients with Goldenhar syndrome. Trigeminal abnormalities showed a good correlation with ipsilateral dysfunction ( P = .018), which further increased when bone foramina abnormalities were included. The facial nerve showed a trend toward correlation with ipsilateral dysfunction ( P = .081). Diplopia was found only in patients with Goldenhar syndrome and was associated with third and sixth cranial nerve abnormalities ( P = .006). CONCLUSIONS: Among patients with oculo-auriculo-vertebral spectrum, cranial nerve morphologic abnormalities are common, correlate with phenotype severity, and often entail a functional impairment. The spectrum of cranial nerve abnormalities appears wider than simple hypo-/aplasia and includes an anomalous cisternal course and partial/complete fusion of diverse cranial nerves. CN : cranial nerve OAVS : oculo-auriculo-vertebral spectru

Particulate Air Pollution, Clock Gene Methylation, and Stroke : Effects on Stroke Severity and Disability

Circadian rhythm disturbances have been consistently associated with the development of several diseases, particularly cardiovascular diseases (CVDs). A central clock in the brain maintains the daily rhythm in accordance with the external environment. At the molecular level, the clock is maintained by \u201cclock genes\u201d, the regulation of which is mainly due to DNA methylation, a molecular mechanism of gene expression regulation, able to react to and be reprogrammed by environmental exposure such as exposure to particulate matter (PM). In 55 patients with a diagnosis of acute ischemic stroke, we showed that PM2.5 exposure experienced before the event influenced clock genes methylation (i.e., circadian locomotor output cycles protein kaput CLOCK, period 2 PER2, cryprochrome 1 CRY1, Neuronal PAS Domain Protein 2 NPAS2), possibly modulating the patient prognosis after the event, as cryptochrome 1 CRY1 and period 1 PER1 methylation levels were associated with the Rankin score. Moreover, if PM2.5 annual average was low, CRY1/CRY2 methylation levels were positively associated with the National Institutes of Health Stroke Scale (NIHSS) score, whereas they were negatively associated if PM2.5 exposure was high. Whether epigenetic changes in clock genes need to be considered as a prognostic marker of stroke or rather a causal agent in stroke development remains to be determined. Further studies are needed to determine the role of clock gene methylation in regulating the response to and recovery after a stroke event

Nose and Sinus Air Flow Model

Air flow in nose and sinuses is studied by means of a simple model based on the steady-state ideal fluid flow assumption and repeated use of Bernoulli's equation. In particular, by describing flow of air drawn in through the vestibulumnasi during inspiration, we investigate how ventilation of the maxillary sinus is affected by surgical removal of part of the lateral walls of the nasal cavity close to the ostiummeatal complex. We find that, according to the model proposed, removal of tissues from this inner part of the nasal cavity may cause a decrease of the flux rate from the maxillary sinus

INQUADRAMENTO CLINICO E MANAGEMENT DELLO SCHWANNOMA ESCLUSIVAMENTE INTRALABIRINTICO

Lo schwannoma intralabirintico (SIL) è un raro tumore benigno (prevalenza 0.1-0.4%) che origina dalle cellule di Schwann situate a ridosso della giunzione cito-neurale dell’VIII n.c. I sintomi clinici includono ipoacusia neurosensoriale monolaterale progressiva (95%), acufeni (51%), disequilibrio (35%), vertigine (22%), fullness (2%). Alla risonanza magnetica (RM) il tumore si presenta come una massa circoscritta, iperintensa in T1, ipointensa in T2 e con enhancement dopo gadolinio nelle immagini T1-pesate. Il management prevede in prima istanza osservazioni seriali con RM “wait and scan approach”. La chirurgia, considerando le complicanze descritte quali anacusia (100%), paralisi VII n.c. (4%), fistola liquorale (5.4%), meningite (1.8%), è riservata a casi limitati e dipende da: età, condizioni generali del paziente, sede e dimensioni del tumore ed è consigliabile in caso di un pattern di crescita invasivo e presenza di sintomi vertiginosi non responsivi al trattamento medico