The hidden burden of adult allergic rhinitis : UK healthcare resource utilisation survey

Funding Funding for this survey was provided by Meda Pharma.Peer reviewedPublisher PD

Effects of allergen immunotherapy in the MASK-air study: a proof-of-concept analysis

info:eu-repo/semantics/publishedVersio

Barriers to Asthma Treatment in the United States: Results From the Global Asthma Physician and Patient Survey

BACKGROUND: The Global Asthma Physician and Patient (GAPP) survey evaluated the perceptions of both physicians and patients on the management of asthma. Here we present the results from the United States (US) subpopulation of the GAPP survey. METHODS: The GAPP Survey was a large, global study (physicians, n = 1733; patients, n = 1726; interviews, n = 3459). In the US, 208 adults (aged ≥ 18 years) with asthma and 224 physicians were recruited. Respondents were questioned using self-administered online interviews with close-ended questionnaires. RESULTS: Physician and patient responses were found to differ in regard to perception of time spent on asthma education, awareness of disease symptoms and their severity, asthma medication side effects, and adherence to treatment and the consequence of nonadherence. Comparison of the US findings with the global GAPP survey results suggest the US physician-patient partnership compared reasonably well with the other countries in the survey. Both patients and physicians cited a need for new asthma medication. CONCLUSIONS: Similar to the global GAPP survey, the US-specific findings indicate that in general there is a lack of asthma control, poor adherence to therapy, and room for improvement in patient-physician communication and partnership in treating asthma

Results on MeV-scale dark matter from a gram-scale cryogenic calorimeter operated above ground

Models for light dark matter particles with masses below 1 GeV/c$^2$ are a natural and well-motivated alternative to so-far unobserved weakly interacting massive particles. Gram-scale cryogenic calorimeters provide the required detector performance to detect these particles and extend the direct dark matter search program of CRESST. A prototype 0.5 g sapphire detector developed for the $\nu$-cleus experiment has achieved an energy threshold of $E_{th}=(19.7\pm 0.9)$ eV, which is one order of magnitude lower than previous results and independent of the type of particle interaction. The result presented here is obtained in a setup above ground without significant shielding against ambient and cosmogenic radiation. Although operated in a high-background environment, the detector probes a new range of light-mass dark matter particles previously not accessible by direct searches. We report the first limit on the spin-independent dark matter particle-nucleon cross section for masses between 140 MeV/c$^2$ and 500 MeV/c$^2$.Comment: 6 pages, 6 figures, v3: ancillary files added, v4: high energy spectrum (0.6-12keV) added to ancillary file

A detector module with highly efficient surface-alpha event rejection operated in CRESST-II Phase 2

The cryogenic dark matter experiment CRESST-II aims at the direct detection of WIMPs via elastic scattering off nuclei in scintillating CaWO$_4$ crystals. We present a new, highly improved, detector design installed in the current run of CRESST-II Phase 2 with an efficient active rejection of surface-alpha backgrounds. Using CaWO$_4$ sticks instead of metal clamps to hold the target crystal, a detector housing with fully-scintillating inner surface could be realized. The presented detector (TUM40) provides an excellent threshold of ${\sim}\,0.60\,$keV and a resolution of $\sigma\,{\approx}\,0.090$ keV (at 2.60$\,$keV). With significantly reduced background levels, TUM40 sets stringent limits on the spin-independent WIMP-nucleon scattering cross section and probes a new region of parameter space for WIMP masses below 3$\,$GeV/c$^2$. In this paper, we discuss the novel detector design and the surface-alpha event rejection in detail.Comment: 9 pages, 6 figure

Results on light dark matter particles with a low-threshold CRESST-II detector

The CRESST-II experiment uses cryogenic detectors to search for nuclear recoil events induced by the elastic scattering of dark matter particles in CaWO$_4$ crystals. Given the low energy threshold of our detectors in combination with light target nuclei, low mass dark matter particles can be probed with high sensitivity. In this letter we present the results from data of a single detector module corresponding to 52 kg live days. A blind analysis is carried out. With an energy threshold for nuclear recoils of 307 eV we substantially enhance the sensitivity for light dark matter. Thereby, we extend the reach of direct dark matter experiments to the sub-region and demonstrate that the energy threshold is the key parameter in the search for low mass dark matter particles.Comment: 8 pages, 8 figure