Sex and gender disparities in patients with advanced gastroesophageal adenocarcinoma: data from the AGAMENON-SEOM registry

Gastroesophageal cancer; Gender; SexCáncer gastroesofágico; Género; SexoCàncer gastroesofàgic; Gènere; SexeBackground Recommendations for research articles include the use of the term sex when reporting biological factors and gender for identities or psychosocial or cultural factors. There is an increasing awareness of incorporating the effect of sex and gender on cancer outcomes. Thus, these types of analyses for advanced gastroesophageal adenocarcinoma are relevant. Patients and methods Patients with advanced gastroesophageal adenocarcinoma from the Spanish AGAMENON-SEOM registry treated with first-line combination chemotherapy were selected. Epidemiology, characteristics of the disease, treatment selection, and results were examined according to sex. Results This analysis included 3274 advanced gastroesophageal adenocarcinoma patients treated with combination chemotherapy between 2008 and 2021: 2313 (70.7%) men and 961 (29.3%) women. Tumors in females were more frequently HER2-negative (67.8% versus 60.8%; P < 0.0001), grade 3 (45.4% versus 36.8%; P < 0.001), diffuse (43.3% versus 26.5%; P < 0.0001), and signet ring cell histology (40.5 versus 23.9%; P < 0.0001). Peritoneal spread was more common in women (58.6% versus 38.9%; P < 0.0001), while liver burden was lower (58.9% versus 71.1%; P < 0.0001). There were no significant differences in treatment recommendation. Treatment doses, density, and duration were comparable between sexes. Women experienced more diarrhea (46% versus 37%; P < 0.0001), neutropenia (51% versus 43%; P < 0.0001), and anemia (62% versus 57%; P < 0.0001). After a median 59.6-month follow-up [95% confidence interval (CI) 54.5-70.8], there were no statistically significant differences between the sexes in progression-free survival [6.21 months (95% CI 5.8-6.5 months) versus 6.08 months (95% CI 5.8-6.3 months); log-rank test, χ2 = 0.1, 1 df, P = 0.8] or in overall survival [10.6 months (95% CI 9.8-11.1 months) versus 10.9 months (95% CI 10.4-11.4 months); log-rank test: χ2 = 0.6, 1 df, P = 0.5]. Conclusion This sex analysis of patients with advanced gastroesophageal adenocarcinoma from the AGAMENON-SEOM registry receiving first-line polychemotherapy found no differences in survival. Although women had worse prognostic histopathology, metastatic disease pattern, and greater toxicity, treatment allocation and compliance were equivalent

Testing the gravitational theory with short-period stars around our Galactic Center

Motion of short-period stars orbiting the supermassive black hole in our Galactic Center has been monitored for more than 20 years. These observations are currently offering a new way to test the gravitational theory in an unexplored regime: in a strong gravitational field, around a supermassive black hole. In this proceeding, we present three results: (i) a constraint on a hypothetical fifth force obtained by using 19 years of observations of the two best measured short-period stars S0-2 and S0-38 ; (ii) an upper limit on the secular advance of the argument of the periastron for the star S0-2 ; (iii) a sensitivity analysis showing that the relativistic redshift of S0-2 will be measured after its closest approach to the black hole in 2018.Comment: 4 pages, 2 figures, proceedings of the 52nd Rencontres de Moriond, Gravitation Sessio

Using topology and neighbor information to overcome adverse vehicle density conditions

Vehicular networks supporting cooperative driving on the road have attracted much attention due to the plethora of new possibilities they offer to modern Intelligent Transportation Systems. However, research works regarding vehicular networks usually obviate assessing their proposals in scenarios including adverse vehicle densities, i.e., density values that significantly differ from the average values, despite such densities can be quite common in real urban environments (e.g. traffic jams). In this paper, we study the effect of these hostile conditions on the performance of different schemes providing warning message dissemination. The goal of these schemes is to maximize message delivery effectiveness, something difficult to achieve in adverse density scenarios. In addition, we propose the Neighbor Store and Forward (NSF) scheme, designed to be used under low density conditions, and the Nearest Junction Located (NJL) scheme, specially developed for high density conditions. Simulation results demonstrate that our proposals are able to outperform existing warning message dissemination schemes in urban environments under adverse vehicle density conditions. In particular, NSF reduces the warning notification time in low vehicle density scenarios, while increasing up to 23.3% the percentage of informed vehicles. As for high vehicle density conditions, NJL is able to inform the same percentage of vehicles than other existing approaches, while reducing the number of messages up to 46.73%This work was partially supported by the Ministerio de Ciencia e Innovacion, Spain, under Grant TIN2011-27543-C03-01, by the Fundacion Universitaria Antonio Gargallo and the Obra Social de Ibercaja, under Grant 2013/B010, as well as the Government of Aragon and the European Social Fund (T91 Research Group).Sanguesa, JA.; Fogue, M.; Garrido, P.; Martinez, FJ.; Cano Escribá, JC.; Tavares De Araujo Cesariny Calafate, CM. (2014). Using topology and neighbor information to overcome adverse vehicle density conditions. Transportation Research Part C: Emerging Technologies. 42:1-13. https://doi.org/10.1016/j.trc.2014.02.010S1134

Review of dohan eherenfest et al. (2009) on “classification of platelet concentrates: from pure platelet-rich plasma (p-prp) to leucocyte- and platelet-rich fibrin (l-prf)”

This classic discusses the original publication of Dohan Eherenfest et al. on "Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)", in which the authors propose four categories of platelet concentrates depending on their leukocyte and fibrin content (P-PRP, leucocyte- and platelet-rich plasma (L-PRP), pure platelet-rich fibrin (P-PRF), and L-PRF) to group a "jungle" of products in which the term platelet-rich plasma (PRP) was used indistinctly. They were able to identify common factors such as: (1) the use of anticoagulant and immediate centrifugation of the blood after its collection, (2) most preparation techniques allowed platelet concentrate preparation within an hour, (3) the centrifugation aimed to separate the blood in layers that would allow the extraction of specific fractions, and (4) the product was activated with thrombin or calcium chloride. The reviewed manuscript has been listed among the most cited PRP articles in regenerative medicine, with more than 800 citations, driving the current scientific research and clinical practice by categorizing L-PRP and P-PRP (now, leukocyte-poor PRP). The classification has also opened the door to understanding intrinsic biological mechanisms between the platelets, leukocytes, fibrin, and growth factors, later considered for studying the proliferation and differentiation of cells in different tissues affected by PRP. Since the initial classification of platelet concentrates, several other classification systems have been proposed and published in the current literature, such as the PAW, Mishra, PLRA, DEPA, MARSPILL, etc. These classifications have identified important aspects of PRP that affect the biological composition and, ultimately, the indications and outcomes. To date, there is still a lack of standardization in sample preparation, cohort heterogeneity, and incomplete reporting of sample preparation utilized, leading to a lack of clarity and challenging researchers and clinicians

RTAD: A real-time adaptive dissemination system for VANETs

Efficient message dissemination is of utmost importance to propel the development of useful services and applications in Vehicular ad hoc Networks (VANETs). In this paper, we propose a novel adaptive system that allows each vehicle to automatically adopt the most suitable dissemination scheme in order to fit the warning message delivery policy to each specific situation. Our mechanism uses as input parameters the vehicular density and the topological characteristics of the environment where the vehicles are located, in order to decide which dissemination scheme to use. We compare our proposal with respect to two static dissemination schemes (eMDR and NJL), and three adaptive dissemination systems (UV-CAST, FDPD, and DV-CAST). Simulation results demonstrate that our approach significantly improves upon these solutions, being able to support more efficient warning message dissemination in all situations ranging from low densities with complex maps, to high densities in simple scenarios. In particular, RTAD improves existing approaches in terms of percentage of vehicles informed, while significantly reducing the number of messages sent, thus mitigating broadcast storms. 2015 Elsevier B.V. All rights reserved.This work was partially supported by the Ministerio de Ciencia e Innovacion, Spain, under Grant TIN2011-27543-C03-01, as well as the Government of Aragon and the European Social Fund (T91 Research Group).Sanguesa, JA.; Fogue, M.; Garrido, P.; Martinez, FJ.; Cano Escribá, JC.; Tavares De Araujo Cesariny Calafate, CM.; Manzoni, P. (2015). RTAD: A real-time adaptive dissemination system for VANETs. Computer Communications. 60:53-70. https://doi.org/10.1016/j.comcom.2015.01.017S53706