Water waves overtopping over barriers

A numerical and experimental analysis of the wave overtopping over emerged and submerged structures, is presented. An original model is used in order to simulate three-dimensional free surface flows. The model is based on the numerical solution of the motion equations expressed in an integral form in time-dependent curvilinear coordinates. A non-intrusive and continuous-in-space image analysis technique, which is able to properly identify the free surface even in very shallow waters or breaking waves, is adopted for the experimental tests. Numerical and experimental results are compared, for several wave and water depth conditions

Spectral singularities for Non-Hermitian one-dimensional Hamiltonians: puzzles with resolution of identity

We examine the completeness of bi-orthogonal sets of eigenfunctions for non-Hermitian Hamiltonians possessing a spectral singularity. The correct resolutions of identity are constructed for delta like and smooth potentials. Their form and the contribution of a spectral singularity depend on the class of functions employed for physical states. With this specification there is no obstruction to completeness originating from a spectral singularity.Comment: 25 pages, more refs adde

Biomechanical performance of the Bicaval Transcatheter System for the treatment of severe tricuspid regurgitation

Introduction: Tricuspid regurgitation (TR) is a relatively common valvular disease, which can result from structural abnormalities of any anatomic part of the tricuspid valve. Severe TR is linked to congestive heart failure and hemodynamic impairment, resulting in high mortality when repaired by elective surgery. This study was undertaken to quantify the structural and hemodynamic performance of the novel Transcatheter Bicaval Valves System (TricValve) percutaneously implanted in the superior vena cava (SVC) and inferior vena cava (IVC) of two patients with severe TR and venous congestion. Methods: After developing the SVC and IVC device models, the contact pressure exerted on the vena cava wall was obtained by computational analysis. Both smoothed-particle hydrodynamics (SPH) and computational fluid dynamics were carried out to quantify caval reflux in the right atrium and the pressure field of pre- and post-TricValve scenarios, respectively. Results: Analysis of contact pressure highlighted the main anchoring area of the SVC device occurring near the SVC device belly, while the IVC device exerted pronounced forces in the device’s proximal and distal parts. SPH-related flow velocities revealed the absence of caval reflux, and a decrease in time-averaged pressure was observed near the SVC and IVC after TricValve implantation. Discussion: Findings demonstrated the potential of computational tools for enhancing our understanding of the biomechanical performance of structural tricuspid valve interventions and improving the way we design next-generation transcatheter therapies to treat the tricuspid valve with heterotopic caval valve implantation

Complex Lagrangians and phantom cosmology

Motivated by the generalization of quantum theory for the case of non-Hermitian Hamiltonians with PT symmetry, we show how a classical cosmological model describes a smooth transition from ordinary dark energy to the phantom one. The model is based on a classical complex Lagrangian of a scalar field. Specific symmetry properties analogous to PT in non-Hermitian quantum mechanics lead to purely real equation of motion.Comment: 11 pages, to be published in J.Phys.A, refs. adde

Equidistance of the Complex 2-Dim Anharmonic Oscillator Spectrum: Exact Solution

We study a class of quantum two-dimensional models with complex potentials of specific form. They can be considered as the generalization of a recently studied model with quadratic interaction not amenable to conventional separation of variables. In the present case, the property of shape invariance provides the equidistant form of the spectrum and the algorithm to construct eigenfunctions analytically. It is shown that the Hamiltonian is non-diagonalizable, and the resolution of identity must include also the corresponding associated functions. In the specific case of anharmonic second-plus-fourth order interaction, expressions for the wave functions and associated functions are constructed explicitly for the lowest levels, and the recursive algorithm to produce higher level wave functions is given.Comment: 17 p.

Glutathione Decrement Drives Thermogenic Program in Adipose Cells

Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione (GSH). Moreover, the treatment with a GSH depleting agent, buthionine sulfoximine (BSO), recapitulates the effect of cold exposure resulting in the induction of thermogenic program. In particular, BSO treatment leads to enhanced uncoupling respiration as demonstrated by increased expression of thermogenic genes (e.g. Ucp1, Ppargc1a), augmented oxygen consumption and decreased mitochondrial transmembrane potential. Buffering GSH decrement by pre-treatment with GSH ester prevents the up-regulation of typical markers of uncoupling respiration. We demonstrate that FoxO1 activation is responsible for the conversion of white adipocytes into a brown phenotype as the "browning" effects of BSO are completely abrogated in cells down-regulating FoxO1. In mice, the BSO-mediated up-regulation of uncoupling genes results in weight loss that is at least in part ascribed to adipose tissue mass reduction. The induction of thermogenic program has been largely proposed to counteract obesity-related diseases. Based on these findings, we propose GSH as a novel therapeutic target to increase energy expenditure in adipocytes.Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione (GSH). Moreover, the treatment with a GSH depleting agent, buthionine sulfoximine (BSO), recapitulates the effect of cold exposure resulting in the induction of thermogenic program. In particular, BSO treatment leads to enhanced uncoupling respiration as demonstrated by increased expression of thermogenic genes (e.g. Ucp1, Ppargc1a), augmented oxygen consumption and decreased mitochondrial transmembrane potential. Buffering GSH decrement by pre-treatment with GSH ester prevents the up-regulation of typical markers of uncoupling respiration. We demonstrate that FoxO1 activation is responsible for the conversion of white adipocytes into a brown phenotype as the "browning" effects of BSO are completely abrogated in cells down-regulating FoxO1. In mice, the BSO-mediated up-regulation of uncoupling genes results in weight loss that is at least in part ascribed to adipose tissue mass reduction. The induction of thermogenic program has been largely proposed to counteract obesity-related diseases. Based on these findings, we propose GSH as a novel therapeutic target to increase energy expenditure in adipocytes

A PT Symmetric QES Partner to the Khare Mandal Potential With Real Eigen Values

We consider a PT Symmetric Partner to Khare Mandal's recently proposed non-Hermitian potential with complex eigen values. Our potential is Quasi-Exactly solvable and is shown to possess only real eigen values.Comment: 10 page

Growth performance and oxidative status in piglets supplemented with verbascoside and teupolioside

Two hundred forty piglets, half female and half barrows, 8.1 ± 1.40 kg LW, were divided into 6 experimental groups and fed ad libitum with a diet supplemented with the following levels of antioxidants: 0 (CON + = positive control added with 100 mg lincomicine/kg), 5 (LT = low teupolioside or LV = low verbascoside), 10 (HT = high teupolioside; HV = high verbascoside; LT+LV) mg/kg of diet for 56 days. Body weight and feed intake were recorded on d0, 14 and 56 of the trial. Ten piglets from each group were selected and blood collected by anterior vena cava puncture at 0, 14 and 56 d for reactive oxygen metabolite (ROMs) determination. HV showed final weight higher than the other groups (P<0.05), and oxidative stability was improved by both integrations of verbascoside. These results support the view that Verbascoside influences the growth performances and oxidative status of piglets