Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function exposed to Gd-based contrast agents

Gadolinium deposition in tissue is linked to nephrogenic systemic fibrosis (NSF): a rare disorder occurring in patients with severe chronic kidney disease and associated with administration of Gd-based contrast agents (GBCAs) for Magnetic Resonance Imaging (MRI). It is suggested that the GBCAs prolonged permanence in blood in these patients may result in a Gd precipitation in peripheral or central organs, where it initiates a fibrotic process. In this study we investigated new sites of retention/precipitation of Gd in a mouse model of renal disease (5/6 nephrectomy) receiving two doses (closely after each other) of a linear GBCA. Two commercial GBCAs (Omniscan\uae and Magnevist\uae) were administered at doses slightly higher than those used in clinical practice (0.7 mmol/kg body weight, each). The animals were sacrificed one month after the last administration and the explanted organs (kidney, liver, femur, dorsal skin, teeth) were analysed by X-ray fluorescence (XRF) at two synchrotron facilities. The XRF analysis with a millimetre-sized beam at the SYRMEP beamline (Elettra, Italy) produced no detectable levels of Gd in the examined tissues, with the notable exception of the incisors of the nephrectomised mice. The XRF analyses at sub-micron resolution performed at ID21 (ESRF, France) allowed to clearly localize Gd in the periodontal ligaments of teeth both from Omniscan\uae and Magnevist\uae treated nephrectomised mice. The latter results were further confirmed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The study prompts that prolonged permanence of GBCAs in blood may result in Gd retention in this particular muscular tissue, opening possibilities for diagnostic applications at this level when investigating Gd-related toxicities

Uso do fogo em pastagens naturais.

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ACTIVIDAD DE ANTISEPTICOS EN Malassezia pachydermatys AISLADA DE OIDO EXTERNO EN PERROS Y GATOS

Se estudiaron en agar Sabouraud dextrosado, muestras obtenidas del conducto auditivo externo de 80 perros y 22 gatos aparentemente sanos. El examen micológico directo y las características morfofisiológicas y bioquímicas, permitieron determinar la presencia de Malassezia pachydermatis en el 61,3% de las muestras provenientes de perros y en el 13,6% de los gatos. La susceptibilidad de esta levadura se determinó en medios sólidos, por el método de dilución in vitro frente a soluciones de yodo, timerosal y violeta de genciana. Todas las cepas fueron inhibidas en las siguientes concentraciones: Yodo 1.0 g/l; Timerosal 0,0125 g/l y Violeta de genciana a 0,0078 g/l, lo que representa su dilución comercial diluida 641 veces

Processo de obtenção e avaliação química de doce cristalizado de bocaiuva.

A polpa da bocaiuva é uma excelente fonte de nutrientes como carboidratos, lipídeos, fibras, vitaminas e minerais, além de compostos com ação antioxidante como b 946;-caroteno, a 945;-tocoferol e fenóis totais. Este trabalho teve por objetivo aproveitar a polpa de bocaiuva produzida pelas comunidades extrativistas do Estado de Mato Grosso do Sul para elaboração e avaliação química de doce cristalizado. Foram testadas duas formulações de xarope: 75% de sacarose + 25% de glicose e 100% de sacarose. Os frutos foram higienizados para obtenção das lascas da polpa, as quais foram submetidas à cocção por 10 min antes da imersão em xarope a 30ºBrix. A cada 24 horas o xarope foi incrementado para 40, 50, 60 e 70ºBrix. Em seguida as lascas foram enxaguadas, drenadas e submetidas à secagem a 55ºC até teor de água de 8-9%. As lascas de polpas e os doces elaborados foram avaliados quanto aos teores de fenóis totais, taninos, atividade antioxidante e quanto à composição centesimal e valor energético total. Os compostos bioativos avaliados e a atividade antioxidante na polpa in natura são elevados. No doce cristalizado de bocaiuva, a adição de glicose/sacarose é mais eficiente na preservação destes compostos do que quando somente sacarose. O doce cristalizado contém elevado valor energético, devido principalmente a adição dos açúcares, e reduzidos teores de cinzas, proteínas e lipídeos. A elaboração de doce cristalizado de bocaiuva é uma alternativa de aproveitamento da polpa, com disponibilização de produtos artesanais com valor agregado e maior tempo de comercialização.Agroecol 2016. 1 CD-ROM. Publicado também em: Cadernos de Agroecologia, v. 11, n. 2, 2016

Elaboração e avaliação de doce cristalizado de bocaiuva.

O presente trabalho objetivou aproveitar a polpa de bocaiuva produzida pelas comunidades extrativistas do Estado de Mato Grosso do Sul para elaboração e avaliação de doce cristalizado

An Algebraic q-Deformed Form for Shape-Invariant Systems

A quantum deformed theory applicable to all shape-invariant bound-state systems is introduced by defining q-deformed ladder operators. We show these new ladder operators satisfy new q-deformed commutation relations. In this context we construct an alternative q-deformed model that preserve the shape-invariance property presented by primary system. q-deformed generalizations of Morse, Scarf, and Coulomb potentials are given as examples

The role of clothing in thermal comfort: how people dress in a temperate and humid climate in Brazil

Abstract Thermal insulation from clothing is one of the most important input variables used to predict the thermal comfort of a building's occupants. This paper investigates the clothing pattern in buildings with different configurations located in a temperate and humid climate in Brazil. Occupants of two kinds of buildings (three offices and two university classrooms) assessed their thermal environment through 'right-here-right-now' questionnaires, while at the same time indoor climatic measurements were carried out in situ (air temperature and radiant temperature, air speed and humidity). A total of 5,036 votes from 1,161 occupants were collected. Results suggest that the clothing values adopted by occupants inside buildings were influenced by: 1) climate and seasons of the year; 2) different configurations and indoor thermal conditions; and 3) occupants' age and gender. Significant intergenerational and gender differences were found, which might be explained by differences in metabolic rates and fashion. The results also indicate that there is a great opportunity to exceed the clothing interval of the thermal comfort zones proposed by international standards such as ASHRAE 55 (2013) - 0.5 to 1.0 clo - and thereby save energy from cooling and heating systems, without compromising the occupants' indoor thermal comfort

An integrated care pathway for cancer patients with diabetes: A proposal from the Italian experience

Diabetes and cancer frequently coexist in the same subject, often with relevant clinical effects on the management and prognosis of the comorbid patient. The existing guidelines, however, do not appropriately address many clinical issues in this setting. Although collaboration between diabetologists and oncologists should play an important role in achieving appropriate levels of care, close coordination or agreement between these specialists is seldom offered. There is an urgent need for greater interdisciplinary integration between all specialists involved in this setting, for a shared approach ensuring that organisational silos are overcome. To this end, the Italian Associations of Medical Diabetologists (AMD) and the Italian Association of Medical Oncology (AIOM) recently established a dedicated Working Group on 'Diabetes and Cancer'. The working group outlined a diagnostic and therapeutic clinical pathway dedicated to hospitalised patients with diabetes and cancer. In this article, we describe the Italian proposal including some suggested measures to assess, monitor and improve blood glucose control in the hospital setting, to integrate different specialists from both areas, as well as to ensure discharge planning and continuity of care from the hospital to the territory

Long Range Magnetic Order and the Darwin Lagrangian

We simulate a finite system of $N$ confined electrons with inclusion of the Darwin magnetic interaction in two- and three-dimensions. The lowest energy states are located using the steepest descent quenching adapted for velocity dependent potentials. Below a critical density the ground state is a static Wigner lattice. For supercritical density the ground state has a non-zero kinetic energy. The critical density decreases with $N$ for exponential confinement but not for harmonic confinement. The lowest energy state also depends on the confinement and dimension: an antiferromagnetic cluster forms for harmonic confinement in two dimensions.Comment: 5 figure