The Importance of Ergonomics on Urban Squares: Case from Istanbul

There is a close relationship between the creation of urban spaces and ergonomics. To make new stimulating and satisfying urban spaces, ergonomics criteria should consider. In this study, two main urban squares from Istanbul examined. Selected urban squares evaluated by site observation according to the classified ergonomics criteria. Strong and weak points of chosen squares discussed and some suggestions proposed. The results demonstrated the fact that urban equipment meets the individual ergonomic criteria are not sufficient in the use of both squares, and they need to be re-planned.Keywords: Ergomomics; urban squares, IstanbuleISSN: 2398-4287 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v4i11.1695           

SppC based energy frontier lepton-proton colliders: luminosity and physics

In this study, main parameters of Super proton-proton Collider (SppC) based lepton-proton colliders are estimated. For electron beam parameters, highest energy International Linear Collider (ILC) and Plasma Wake Field Accelerator-Linear Collider (PWFA-LC) options are taken into account. For muon beams, 1.5 TeV and 3 TeV center of mass energy Muon Collider parameters are used. In addition, ultimate $\mu$p collider which assumes construction of additional 50 TeV muon ring in the SppC tunnel is considered as well. It is shown that $L_{ep}$ $\sim$ $10^{32}$ $cm^{-2}s^{-1}$ can be achieved with moderate upgrade of the SppC proton beam parameters. Physics search potential of proposed lepton-proton colliders is illustrated by considering small Bjorken x region as an example of SM physics and resonant production of color octet leptons as an example of BSM physics.Comment: 11 pages, 3 figures, 8 table

Investigating Urban Ergonomics Features through Healthy City Approach: The Case of Istanbul and Singapore

This study aims to investigate urban ergonomics features through the healthy city approach. Analytic Hierarchy Process (AHP) is adopted to make a pairwise comparison and ranking of multiple features of urban ergonomics. A small online panel was organized with ten experts of architecture and urban design with a minimum of 10 years of experience. Findings from the literature were shared with these experts, and they were asked to compare the ergonomics features pairwise and rank them. For the next step, two main urban squares from Istanbul and two main public spaces of Singapore are examined. Keywords: Ergonomics; Healthy city; Istanbul; Singapore. eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v6i16.272

Investigating the Single Production of Vector-Like Quarks Decaying into Top Quark and W Boson through Hadronic Channels at the HL-LHC

We investigate the single production of vector-like quarks at the High Luminosity LHC (HL-LHC). With the assumed (enhanced) couplings to third generation quarks of the standard model, vector-like quarks $B/X$ are produced in association with a bottom ($b$) or top ($t$) quark, which correspond to $Bbq$ and $Btq/Xtq$ production modes, including an additional soft forward jet from the spectator quark ($q$). This study focuses on high-mass vector-like quarks $B/X$ decaying into a top quark and a $W$ boson, resulting in the final state jets emerging from hadronically decaying top quark ($t\to Wb$) and $W$ boson ($W\to q\bar{q}'$). The events with $W$ boson and $t$ quark have been analysed using tagging techniques for large-radius jets. The scan ranges of the mass ($1000<m_{B}<3000$ GeV) for the relative width $\Gamma_{B/X}/m_{B/X}=0.1$ of vector-like $B/X$ quarks have been investigated. From the results of the analysis, the masses of vector like quarks B (X) up to 2550 (2450) GeV can be excluded at $95\%$ CL depending on the type and branching scenarios at integrated luminosity projection of $3$ ab$^{-1}$ at the HL-LHC.Comment: 18 pages, 5 Tables, 6 Figure

Alcohol consumption leads to loss of healthy life, but the ADH1B*2 allele may still protect from NASH

Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease worldwide, affecting almost a quarter of the world population (1,2), and is a main cause of severe hepatic complications such as cirrhosis and liver cancer. In histological assessment NAFLD and alcoholic liver disease (ALD) are difficult to distinguish; NAFLD diagnosis thus requires a limit of alcohol intake. However, NAFLD and ALD very frequently coexist in the same patient, making it difficult to identify the exact cause of liver complications. Almost 5?6% of all worldwide deaths (~3 million) are caused by the harmful use of alcohol (https://www.who.int/publications/i/item/9789241565639), therefore alcohol represents a major health problem at a global scale. There is an association between the amount of alcohol consumption and ALD, however, only 30% of chronic drinkers develop alcoholic hepatitis, and 10?20% progress to advanced fibrosis or cirrhosis (3), underscoring the role of genetic factors involved in disease severity and progression. Any level of alcohol consumption, regardless of the amount, leads to loss of healthy life. The recommendation in clinical practice should be to avoid alcohol intake, particularly in the presence of any liver disease. Moderate alcohol consumption has been reported by many studies to be associated with less severe NAFLD, although some of these cross-sectional studies may be affected by selection bias (4-6). In contrast a longitudinal analysis of liver biopsies from patients with NAFLD showed that modest alcohol consumption was associated with lower NASH resolution in comparison with nondrinkers (7). Recently, Chang et al. showed that the risk of liver steatosis in low and moderate alcohol consumers (MACs) was lower in comparison with nondrinkers (8); however, the proportion of hepatic steatosis plus fibrosis was higher in drinkers. The exact mechanism of the deleterious effect of alcohol consumption on NAFLD in obese patients is still unclear. When combined with free fatty acids the polyphenol resveratrol resulted in the stimulation of profibrogenic effects in hepatic stellate cells (key cells for induction and propagation of hepatic fibrosis) instead of any protective role (9). Therefore, it is important to shed light on the exact role of alcohol intake in addition to NAFLD to solve the currently rather conflicting data on this issue. The work published by Vilar-Gomez et al. in Gastroenterology (10) clarifies some knowledge gaps about alcohol metabolism and consumption, and the severity of NAFLD by studying the role of alcohol dehydrogenase (ADH)-1B, in particular ADH1B*2, in this context. The authors started from a finding generated in a previous work by Sookoian et al., where they observed that patients with low alcohol intake and the ADH1B*2 allele showed a less severe NAFLD by histology compared to other patients studied (11). Vilar-Gomez et al. studied 1,697 patients enrolled into various studies conducted by the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) over a period of 10 years [2009?2019]; the NASH CRN Pathology committee reviewed all liver biopsies, and comprehensive alcohol consumption was obtained by AUDIT and LDH questionnaire, binge and heavy drinkers were excluded (170 patients). Remarkably, the frequency of ADH1B*2 carriage varied across race being high in Asians/Pacific Islanders/Hawaiians (86%) and low in non-Hispanic whites (8%), Hispanics (14%), and Blacks (4%), but the study was focused on the 1,153 non-Hispanic whites, which were mainly female, obese, and hypertensive. Among the 1,153 patients, 30% had advanced fibrosis, and 60% had definite NASH. The cohort included 720 non-drinkers and 433 moderate drinkers, but no heavy alcohol consumers. ADH1B*2 carriers were more likely to be male, and moderate alcohol consumption was similar between ADH1B*1 and ADH1B*2 carriersFil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Canbay, Ali. Ruhr Universität Bochum; Alemani

İlköğretim birinci kademede çoklu zeka kuramı uygulamalarına ilişkin öğretmen görüşleri (Yalova örneği)

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu araştırmanın amacı, ilköğretim birinci kademede Çoklu Zekâ Kuramı uygulamalarının şuanki okul ve sınıflarımızın mevcut durumlarına uygun olup olmadığı; uygun ise bunun düzeyinitespit etmektir.Araştırmada, öncelikle zekâ ile ilgili son gelişmelerden yaralanılarak eğitimde uygulanan ÇokluZekâ Kuramı, literatür taraması yapılarak ortaya konulmaya çalışılmıştır. Çoklu Zekâ Kuramıuygulayıcısı olan öğretmenlerin kuram hakkındaki görüş ve düşüncelerini öğrenmek için bir deanket çalışması yapılmıştır.Anketler Yalova ilinde yer alan ilköğretim okullarının birinci kademelerinde görev yapan 240sınıf öğretmenine uygulanmıştır. Ankette öğretmenlerin Çoklu Zekâ Kuramı uygulamalarınakarşı geliştirdikleri tutum ve yaklaşımlara ait 40 soru yer almış, ayrıca anketin sonundaöğretmenlerin görüşlerini yazılı olarak belirttikleri bir bölüme de yer verilmiştir.Ankette toplanan verilerin değerlendirilmesi sonunda; öğretmenler Çoklu Zekâ Kuramıuygulamalarının öğrenmede kalıcılık üzerinde daha etkili olduğunu, Çoklu Zekâ Kuramı'nagöre ders işlemenin geleneksel yöntemlere göre ders işlemekten daha iyi sonuç verdiğini,öğrencilerinin Çoklu Zekâ Kuramı'na göre ders işlerken derste daha aktif olduklarını ifadeetmişlerdir. Bunun yanında öğretmenler araç-gereç sıkıntısı yaşadıklarını, sınıfların kalabalıkolmasından rahatsızlık duyduklarını gerek kendilerinin, gerek yöneticilerin, gereksemüfettişlerin eğitim alması gerektiğini dile getirmişlerdir. Sorunların giderilmesi için MilliEğitim Bakanlığı'ndan ve program geliştiricilerden beklentilerinin olduğu belirtilebilir.Anahtar Kelimeler: Çoklu Zekâ Kuramı Uygulamaları, Sınıf Öğretmenleri, Öğrenmede KalıcılıkThe aim of the research is to determine if the applications of Multiple Intelligence Theory areappropriate for our schools and classes present conditions or not, if appropriate to determine itsdegree.In this research, Multiple Intelligence Theory which is used in education, is introduced by usingsouice search model, primarily by taking advantage of recent improvements and evidencesabout intelligence. An inquiry has been made in order to learn the teachers; who are theoperators of Multiple Intelligence Theory, ideas and opinions.The inquiries has been applied to 240 teachers all of whom Works in the first grades of theprimary schools in Yalova. In the inquiry there are 40 questions about the teachers attitudes ineducation towards the Multiple choice Intelligence. Besides, at the end of the inquiry there is apart where teachers can express their opinions written.The result of the increasing the value of the datas, which were collected from the inquiry;teachers expresed that, the applications of Multiple Intelligence Theory are more effective onpermanency on learning, that beter results are got when studying according to MultipleIntelligence Theory than traditional methods and that students are more active during the lessonwhen studying according to Multiple Intelligence Theory. Also teachers told that they have gotsome problems about finding equipments and crowdet classes. They agree that adminintiators,inspectors and they must have more detailed seminars about education on the subject ofMultiple Intelligence Theory. They have got expectations from National Education Ministryand program developers in order to solve their problems.Keywords: Multiple Intelligence Theory Applications, Teachers, Permanency on Learning

Galactic Model Parameters and Space Density of Cataclysmic Variables in Gaia Era: New Constraints to Population Models

The spatial distribution, Galactic model parameters and luminosity function of cataclysmic variables (CVs) are established using re-estimated trigonometric parallaxes of {\it Gaia} DR3. The data sample of 1,587 CVs in this study is claimed to be suitable for Galactic model parameter estimation as the distances are based on trigonometric parallaxes and the {\it Gaia} DR3 photometric completeness limits were taken into account when the sample was created. According to the analysis, the scale height of All CVs increases from 248$\pm$2 to 430$\pm$4 pc towards shorter periods near the lower limit of the period gap and suddenly drops to 300$\pm$2 pc for the shortest orbital period CVs. The exponential scale heights of All CVs and magnetic systems are found to be 375$\pm$2 and 281$\pm$3 pc, respectively, considerably larger than those suggested in previous observational studies. The local space density of All CVs and magnetic systems in the sample are $6.8^{+1.3}_{-1.1}\times$10$^{-6}$ and $2.1^{+0.5}_{-0.4}\times10^{-6}$ pc$^{-3}$, respectively. Our measurements strengthen the 1-2 order of magnitude discrepancy between CV space densities predicted by population synthesis models and observations. It is likely that this discrepancy is due to objects undetected by CV surveys, such as the systems with very low $\dot{M}$ and the ones in the period gap. The comparisons of the luminosity function of white dwarfs with the luminosity function of All CVs in this study show that 500 times the luminosity function of CVs fits very well to the luminosity function of white dwarfs. We conclude that the estimations and data sample in this study can be confidently used in further analysis of CVs.Comment: 23 pages, including 12 figures and 6 tables, accepted for publication in the Astronomical Journa

A phase 2, randomized, double‐blind, placebo‐controlled study of GS‐9450 in subjects with nonalcoholic steatohepatitis

In nonalcoholic steatohepatitis (NASH), the extent of hepatocyte apoptosis correlates with disease severity. Reducing hepatocyte apoptosis with the selective caspase inhibitor GS‐9450 has a potential for altering the course of the liver disease. In this phase 2, double‐blind study, 124 subjects with biopsy‐proven NASH were randomized to once‐daily placebo or 1, 5, 10, or 40 mg GS‐9450 for 4 weeks. Absolute and percent changes from baseline in ALT levels, AST levels, and caspase‐3–cleaved cytokeratin (CK)‐18 fragments at week 4 were assessed by an analysis of covariance model with adjustment for baseline values. In the 40‐mg group, mean (SD) ALT decreased by 47 (43) U/L from baseline to week 4 ( P < 0.0001 versus placebo), and the proportion of subjects with normal ALT increased from 0% to 35% at week 4. In the 40‐mg group, mean AST decreased by 13 U/L from baseline (not significant), and the proportion with normal AST increased from 20% at baseline to 48% at week 4. By week 4, mean CK‐18 fragment levels had decreased to 393 (723) U/L in the GS‐9450 10‐mg group and 125 (212) U/L in the 40‐mg group, but these reductions were not statistically significant. No serious adverse events were reported during treatment, and the percentage of subjects with at least one treatment‐emergent grade 3 or 4 laboratory abnormality ranged from 11.5% to 17% across the GS‐9450 treatment groups versus 35% in the placebo group. Conclusion : GS‐9450 treatment induced significant reductions in ALT levels in NASH patients. Reductions in CK‐18 fragment levels also occurred, although they were not statistically significant. At appropriate therapeutic indices, selective caspase inhibitors may be a promising treatment option in patients with NASH. (H epatology 2012)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90118/1/24747_ftp.pd