Development of Acute Promyelocytic Leukemia in a Patient With Gouty Arthritis on Long Term Colchicine

Colchicine is a frequently used drug in rheumatological diseases. Acute promyelocytic leukemia developed in a patient who used colchicine for gouty arthritis since 10 years is presented and the possible relation between the long term use of colchicine and hematological malignancies is discussed

Predictors of enhancing human physical attractiveness: Data from 93 countries

People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as applying makeup or using other cosmetics, hair grooming, clothing style, caring for body hygiene, and exercising or following a specific diet for the specific purpose of improving ones physical attractiveness, are universal. Indeed, 99% of participants reported spending >10 min a day performing beauty-enhancing behaviors. The results largely support evolutionary hypotheses: more time was spent enhancing beauty by women (almost 4 h a day, on average) than by men (3.6 h a day), by the youngest participants (and contrary to predictions, also the oldest), by those with a relatively more severe history of infectious diseases, and by participants currently dating compared to those in established relationships. The strongest predictor of attractiveness-enhancing behaviors was social media usage. Other predictors, in order of effect size, included adhering to traditional gender roles, residing in countries with less gender equality, considering oneself as highly attractive or, conversely, highly unattractive, TV watching time, higher socioeconomic status, right-wing political beliefs, a lower level of education, and personal individualistic attitudes. This study provides novel insight into universal beauty-enhancing behaviors by unifying evolutionary theory with several other complementary perspectives

Spinal anesthesia in a patient with Darier’s disease: A case report

Darier’s Disease (Darier-White Disease, keratosis follicularis) is a rare genodermatosis characterized by keratinisation defects that affects the skin, nails and mucosal membranes; it is autosomal and dominantly inherited. To the best of our knowledge, only one case has been reported regarding spinal anesthesia management in a patient suffering from Darier’s disease—this was during Cesarean section. Here, we describe a case of spinal anesthesia with standard skin preparation for inguinal hernia surgery in a Darier’s patient. Spinal anesthesia is a safe anesthesia choice when administered in lesion-free areas

Hematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease: Problems and Solutions

Sickle cell disease-related organ injuries cannot be prevented despite hydroxyurea use, infection prophylaxis, and supportive therapies. As a consequence, disease-related mortality reaches 14% in adolescents and young adults. Hematopoietic stem cell transplantation is a unique curative therapeutic approach for sickle cell disease. Myeloablative allogeneic hematopoietic stem cell transplantation is curative for children with sickle cell disease. Current data indicate that long-term disease-free survival is about 90% and overall survival about 95% after transplantation. However, it is toxic in adults due to organ injuries. In addition, this curative treatment approach has several limitations, such as difficulties to find donors, transplant-related mortality, graft loss, graft-versus-host disease (GVHD), and infertility. Engraftment effectivity and toxicity for transplantations performed with nonmyeloablative reduced-intensity regimens in adults are being investigated in phase 1/2 trials at many centers. Preliminary data indicate that GVHD could be prevented with transplantations performed using reduced-intensity regimens. It is necessary to develop novel regimens to prevent graft loss and reduce the risk of GVHD

Waste Management of Nigde Province Cattle Enterprises

WOS: 000467877800012Cattle breeding is a sector that is constantly developing and growing along with other animal product outputs as well as providing the basic foodstuffs of Turkey. While animal husbandry and side facilities are constantly growing, the wastes also come into play proportionally. Despite the fact that these wastes are processable and controllable, they are left uncontrollably and cause irreparable damage to our natural resources. The leaching pollutants to the groundwater during the holding of the wastes may lead to the pollution of the environment along with a bad odor in the region. This study was conducted to evaluate the current state of the wastes formed in the stables and the operations applied to these wastes in Nigde province and its districts where typical local cattle livestock activities were present. A questionnaire was applied to 187 cattle husbandry operations (beef-milk cattle). The obtained data was interpreted and compared with the literature and the current situation was presented. The study results indicated that no waste management system was found in nearly all of the enterprises. Additionally, the waste management systems owning enterprises were inadequate and the wastes were kept in unhealthy conditions