788 research outputs found
Monte Carlo simulation of near-field terahertz emission from semiconductors
We simulated the carrier dynamics in InGaAs after ultrafast photoexcitation. By using a finite-difference time-domain approach we were able to analyze the near terahertz field emission caused by the motion of such carriers. We found that both the current parallel and normal to the interface take a relevant role in the terahertz emission. We also found that the ballistic motion of the carriers after photoexcitation dominates the emission rather than diffusion
Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids.
Use of multicellular tumor spheroids (MTS) to investigate therapies has gained impetus because they have potential to mimic factors including zonation, hypoxia and drug-resistance. However, analysis remains difficult and often destroys 3D integrity. Here we report an optical technique using targeted nanosensors that allows in situ 3D mapping of redox potential gradients whilst retaining MTS morphology and function. The magnitude of the redox potential gradient can be quantified as a free energy difference (ΔG) and used as a measurement of MTS viability. We found that by delivering different doses of radiotherapy to MTS we could correlate loss of ΔG with increasing therapeutic dose. In addition, we found that resistance to drug therapy was indicated by an increase in ΔG. This robust and reproducible technique allows interrogation of an in vitro tumor-model's bioenergetic response to therapy, indicating its potential as a tool for therapy development.Leverhulme Trust (Grant ID: RPG-2012-680), Jamie King Cancer Research FundThis is the final version of the article. It first appeared from the Royal Society of Chemistry via http://dx.doi.org/10.1039/C6NR06031
Sigma-phase in Fe-Cr and Fe-V alloy systems and its physical properties
A review is presented on physical properties of the sigma-phase in Fe-Cr and
Fe-V alloy systems as revealed both with experimental -- mostly with the
Mossbauer spectroscopy -- and theoretical methods. In particular, the following
questions relevant to the issue have been addressed: identification of sigma
and determination of its structural properties, kinetics of alpha-to-sigma and
sigma-to-alpha phase transformations, Debye temperature and Fe-partial phonon
density of states, Curie temperature and magnetization, hyperfine fields,
isomer shifts and electric field gradients.Comment: 26 pages, 23 figures and 83 reference
Recommended from our members
Impact of particles on the Planck HFI detectors: Ground-based measurements and physical interpretation
The Planck High Frequency Instrument (HFI) surveyed the sky continuously from
August 2009 to January 2012. Its noise and sensitivity performance were
excellent, but the rate of cosmic ray impacts on the HFI detectors was
unexpectedly high. Furthermore, collisions of cosmic rays with the focal plane
produced transient signals in the data (glitches) with a wide range of
characteristics. A study of cosmic ray impacts on the HFI detector modules has
been undertaken to categorize and characterize the glitches, to correct the HFI
time-ordered data, and understand the residual effects on Planck maps and data
products. This paper presents an evaluation of the physical origins of glitches
observed by the HFI detectors. In order to better understand the glitches
observed by HFI in flight, several ground-based experiments were conducted with
flight-spare HFI bolometer modules. The experiments were conducted between 2010
and 2013 with HFI test bolometers in different configurations using varying
particles and impact energies. The bolometer modules were exposed to 23 MeV
protons from the Orsay IPN TANDEM accelerator, and to Am and Cm
-particle and Fe radioactive X-ray sources. The calibration data
from the HFI ground-based preflight tests were used to further characterize the
glitches and compare glitch rates with statistical expectations under
laboratory conditions. Test results provide strong evidence that the dominant
family of glitches observed in flight are due to cosmic ray absorption by the
silicon die substrate on which the HFI detectors reside. Glitch energy is
propagated to the thermistor by ballistic phonons, while there is also a
thermal diffusion contribution. The implications of these results for future
satellite missions, especially those in the far-infrared to sub-millimetre and
millimetre regions of the electromagnetic spectrum, are discussed.Comment: 11 pages, 13 figure
Potential health impacts of heavy metals on HIV-infected population in USA.
Noninfectious comorbidities such as cardiovascular diseases have become increasingly prevalent and occur earlier in life in persons with HIV infection. Despite the emerging body of literature linking environmental exposures to chronic disease outcomes in the general population, the impacts of environmental exposures have received little attention in HIV-infected population. The aim of this study is to investigate whether individuals living with HIV have elevated prevalence of heavy metals compared to non-HIV infected individuals in United States. We used the National Health and Nutrition Examination Survey (NHANES) 2003-2010 to compare exposures to heavy metals including cadmium, lead, and total mercury in HIV infected and non-HIV infected subjects. In this cross-sectional study, we found that HIV-infected individuals had higher concentrations of all heavy metals than the non-HIV infected group. In a multivariate linear regression model, HIV status was significantly associated with increased blood cadmium (p=0.03) after adjusting for age, sex, race, education, poverty income ratio, and smoking. However, HIV status was not statistically associated with lead or mercury levels after adjusting for the same covariates. Our findings suggest that HIV-infected patients might be significantly more exposed to cadmium compared to non-HIV infected individuals which could contribute to higher prevalence of chronic diseases among HIV-infected subjects. Further research is warranted to identify sources of exposure and to understand more about specific health outcomes
Axion searches with the EDELWEISS-II experiment
We present new constraints on the couplings of axions and more generic
axion-like particles using data from the EDELWEISS-II experiment. The EDELWEISS
experiment, located at the Underground Laboratory of Modane, primarily aims at
the direct detection of WIMPs using germanium bolometers. It is also sensitive
to the low-energy electron recoils that would be induced by solar or dark
matter axions. Using a total exposure of up to 448 kg.d, we searched for
axion-induced electron recoils down to 2.5 keV within four scenarios involving
different hypotheses on the origin and couplings of axions. We set a 95% CL
limit on the coupling to photons GeV in
a mass range not fully covered by axion helioscopes. We also constrain the
coupling to electrons, , similar to the more
indirect solar neutrino bound. Finally we place a limit on , where is the
effective axion-nucleon coupling for Fe. Combining these results we
fully exclude the mass range keV for DFSZ axions and
keV for KSVZ axions
- …