‘Through Collaboration to Sharawadji: Immediacy, Mediation and the Voice.’

This article analyses the composition and experience of Proto-type’s The Good, the God and the Guillotine (2014) from three critical positions central to the making process: Andrew Westerside, from the position of director and performer-singer; Martin Blain, from the position of composer-performer and Jane Turner, from the position of Dramaturge. It addresses an emergent connection between the sharawadji effect and the techno-sublime, made possible in this performance through the disturbances of technology and the ‘technologically uncanny’. The objective of the article is twofold. The first is to demonstrate how both internally (to the performer) and externally (to the spectator) experiences of sharawadji and the sublime might emerge. Secondly, it proposes these experiences – notably sharawadji – as a product of the interdisciplinary process, and suggests in doing so a productive relationship between the often conflicting or unresolved dramaturgies that are created across performance disciplines

Discurso e identidade: breve caracterização linguístico-discursiva do populismo

Este artigo tem como objetivo discutir a relaçãoentre discurso e identidade no âmbito linguístico-discursivo, de modo a caracterizar o discurso político presidencial populista no contexto histórico brasileiro da década de 1950. Identificamos no populismo um objeto de estudo a ser explorado em função da escassa literatura referente à análise linguística desse fenômeno político, o qual marcou os governos latino-americanos entre as décadas de 1950 e 1960. Interessa-nos, assim, estabelecer uma aproximação teórica entre a análise retórica do discurso e o contexto histórico em que os pronunciamentos de Vargas foram realizados, de modo a contribuir para a caracterização discursivo-identitária, ainda que breve, do populismo. Para procedermos às análises, foram selecionados discursos proferidos por Getúlio Vargas no período de seu segundo mandato como presidente da República (1951-54), extraídos do livro O governo trabalhista do Brasil – volumes III e IV, reunidos e editados pela Livraria José Olympio, em 1969. Como aporte teórico sobre discurso político, recorremos aos trabalhos de Aquino (2005, 2003 e 1997) e Charaudeau (2006); sobre populismo, aos de Capelato (2001), Ferreira (2001) e Weffort (1982); e, finalmente, acerca de gêneros textuais, aos de Bakhtin (2003 [1927]) e Grillo (2006). Buscamos explicitar, ao longo do trabalho, as estratégias de seleção lexical que contribuem para a constituição identitária do populismo como fenômeno discursivo

Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery

ImportanceBefore surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.ObjectiveTo evaluate whether a continuation strategy vs a discontinuation strategy of RASIs before major noncardiac surgery results in decreased complications at 28 days after surgery.Design, setting, and participantsRandomized clinical trial that included patients who were being treated with a RASI for at least 3 months and were scheduled to undergo a major noncardiac surgery between January 2018 and April 2023 at 40 hospitals in France.InterventionPatients were randomized to continue use of RASIs (n = 1107) until the day of surgery or to discontinue use of RASIs 48 hours prior to surgery (ie, they would take the last dose 3 days before surgery) (n = 1115).Main outcomes and measuresThe primary outcome was a composite of all-cause mortality and major postoperative complications within 28 days after surgery. The key secondary outcomes were episodes of hypotension during surgery, acute kidney injury, postoperative organ failure, and length of stay in the hospital and intensive care unit during the 28 days after surgery.ResultsOf the 2222 patients (mean age, 67 years [SD, 10 years]; 65% were male), 46% were being treated with angiotensin-converting enzyme inhibitors at baseline and 54% were being treated with angiotensin receptor blockers. The rate of all-cause mortality and major postoperative complications was 22% (245 of 1115 patients) in the RASI discontinuation group and 22% (247 of 1107 patients) in the RASI continuation group (risk ratio, 1.02 [95% CI, 0.87-1.19]; P = .85). Episodes of hypotension during surgery occurred in 41% of the patients in the RASI discontinuation group and in 54% of the patients in the RASI continuation group (risk ratio, 1.31 [95% CI, 1.19-1.44]). There were no other differences in the trial outcomes.Conclusions and relevanceAmong patients who underwent major noncardiac surgery, a continuation strategy of RASIs before surgery was not associated with a higher rate of postoperative complications than a discontinuation strategy.Trial registrationClinicalTrials.gov Identifier: NCT03374449

Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development

Several highly conserved genes play a role in anterior neural plate patterning of vertebrates and in head and brain patterning of insects. However, head involution in Drosophila has impeded a systematic identification of genes required for insect head formation. Therefore, we use the red flour beetle Tribolium castaneum in order to comprehensively test the function of orthologs of vertebrate neural plate patterning genes for a function in insect head development. RNAi analysis reveals that most of these genes are indeed required for insect head capsule patterning, and we also identified several genes that had not been implicated in this process before. Furthermore, we show that Tc-six3/optix acts upstream of Tc-wingless, Tc-orthodenticle1, and Tc-eyeless to control anterior median development. Finally, we demonstrate that Tc-six3/optix is the first gene known to be required for the embryonic formation of the central complex, a midline-spanning brain part connected to the neuroendocrine pars intercerebralis. These functions are very likely conserved among bilaterians since vertebrate six3 is required for neuroendocrine and median brain development with certain mutations leading to holoprosencephaly

Manual de patología general

BNE, 26/10/2016, da como fecha probable para esta edición ca. 1910-1930Data deducida dos editore

Précis de pathologie générale

En la portada: Avec 147 figures intercalées dans le texteNa port.: Avec 147 figures intercalées dans le text