Queer Practice as Research: A Fabulously Messy Business

This short piece highlights a current spurt in queer researcher–practitioners doing practice as research (PaR) in higher education and explores potential reasons why PaR is so vital, appealing, useful and strategic for queer research. As a starting point, we offer the idea of messiness and messing things up as a way of describing the methods of PaR. Queer mess is to do with asserting the value and pleasure of formations of knowledge that sit outside long-standing institutional hierarchies of research. The latter places what Robin Nelson calls ‘hard knowledge’ above tacit, quotidian, haptic and embodied knowledge. The methodological and philosophical impulses of PaR make space for a range of research methods inherently bound up with the researcher as an individual and the materiality of lived experience within research. Yet, in our experience, although each PaR project is individual, PaR projects follow certain shared modes evolving largely from embodied and heuristic research methods adapted from social sciences, such as (auto)ethnography, participant observation, phenomenology and action research. PaR methodology in theatre and performance is composed of a bricolage of these openly embodied methods, which makes PaR, as an embodied resistance to sanitary boundaries, somewhat queer in academic terms already. It is unsurprising, then, that PaR is so attractive to queer practitioner–researchers bent on queering normative hierarchies of knowledge

From Bogeyman to Bison: A herd-like amnesia of HIV?

Copyright @ The International Federation for Theatre Research, 2011Queer theorists from across a broad range of disciplines argue that we are in a 'normalizing’ or ‘homonormative’ period, in which marginalized subjectivities strive to align themselves with hegemonic norms. In terms of LGBTQ rights and representation, it can be argued that this has resulted in an increased visibility of ‘desirable’ gays (monogamous – ideally civil-partnered, white, financially independent, able-bodied) and the decreased visibility of ‘undesirable’ gays (the sick, the poor, the non-white, the non-gender-conforming). Focusing specifically on the effects of this hierarchy on the contemporary theatrical representation of gay HIV/AIDS subjectivities, this article looks at two performances, Reza Abdoh's Bogeyman (1991) and Lachlan Philpott's Bison (2009–10). The article argues that HIV/AIDS performance is as urgently necessary today as in the early 1990s, and that a queer dramaturgy, unafraid to resist the lure of normativity or the ‘gaystreaming’ of LGBT representation, is a vital intervention strategy in contemporary (LGBT) theatre

On Care-fulness: Critical Creative Expressions of Care in a Feminist Theatre Research Project

In early 2020, as the first of many COVID lockdowns began across Australia, a collective of feminist and queer performance scholars and artists embarked on the research project Staging Australian Women’s Lives: Theatre, Feminism and Socially Engaged Art. Our aim was to document contributions of womxn theatre makers, while conducting a feminist analysis of strategies used to deal with gender inequality and oppression, on stage and off. While pivoting to the digital and the virtual, we recognised a need to support womxn theatre makers whose lives and livelihoods are thrown into further precarity by the pandemic. This paper speaks to our commitment to bringing together critical theory, arts practices and everyday life in ethical forms and encounters that make visible, recognise and express care for one another and for the work

The Lantern Vol. 68, No. 2, Spring 2001

• Eden • Ginsberg Mourning • On the Cusp of Winter • (Woman: as Needing to be Silver and Sharp) • Descended • Book Unbinding • Scrawlings on the Stall • My Frankenstein • Jazzy Avantguardia • Paper Crane • A Child\u27s Valentine • Ten Years\u27 Gone • Out the Window • Tar\u27s Melting • Passing Time • Ave Maria • Heart of the Matter • Damn Kids • The Candle Incident • Nostalgia • Cuban Couch • Dinner Datehttps://digitalcommons.ursinus.edu/lantern/1158/thumbnail.jp

The HIV Envelope but Not VSV Glycoprotein Is Capable of Mediating HIV Latent Infection of Resting CD4 T Cells

HIV fusion and entry into CD4 T cells are mediated by two receptors, CD4 and CXCR4. This receptor requirement can be abrogated by pseudotyping the virion with the vesicular stomatitis virus glycoprotein (VSV-G) that mediates viral entry through endocytosis. The VSV-G-pseudotyped HIV is highly infectious for transformed cells, although the virus circumvents the viral receptors and the actin cortex. In HIV infection, gp120 binding to the receptors also transduces signals. Recently, we demonstrated a unique requirement for CXCR4 signaling in HIV latent infection of blood resting CD4 T cells. Thus, we performed parallel studies in which the VSV-G-pseudotyped HIV was used to infect both transformed and resting T cells in the absence of coreceptor signaling. Our results indicate that in transformed T cells, the VSV-G-pseudotyping results in lower viral DNA synthesis but a higher rate of nuclear migration. However, in resting CD4 T cells, only the HIV envelope-mediated entry, but not the VSV-G-mediated endocytosis, can lead to viral DNA synthesis and nuclear migration. The viral particles entering through the endocytotic pathway were destroyed within 1–2 days. These results indicate that the VSV-G-mediated endocytotic pathway, although active in transformed cells, is defective and is not a pathway that can establish HIV latent infection of primary resting T cells. Our results highlight the importance of the genuine HIV envelope and its signaling capacity in the latent infection of blood resting T cells. These results also call for caution on the endocytotic entry model of HIV-1, and on data interpretation where the VSV-G-pseudotyped HIV was used for identifying HIV restriction factors in resting T cells

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Adapting musicology’s use of affect theories to contemporary theatre-making: directing Martin Crimp’s Attempts on Her Life

Copyright @ Intellect 2011Adopting and adapting musicology's use of affect theories, specifically Jeremy Gilbert's idea of an 'affective analysis' and David Epstein's idea of 'shaping affect', this article looks at Martin Crimp's Attempts on Her Life from a practitioner's perspective. It investigates the challenges and benefits of adopting an 'affective approach' to directing recent theatre texts that stress the musicality and corporeality of language along with, and at times above, its signifying roles. Rather than locating Aristotelian dramatic climaxes based on narratological or characterological progression, an affective approach seeks to identify moments of affective intensity, which produce a different sort of impact by working on a 'body-first' methodology, rather than the directly cerebral. That this embodied impact is not ultimately meaningless is one of affect theory's most vital assertions. This approach has resonance in terms of how directors, performers and critics/theorists approach work of this type