Brain organoids as innovative tool for regenerative medicine

The introduction of the tridimensional (3D) organoids technology is revolutionizing the fields of developmental and stem cell biology and it is emerging as the latest frontier in regenerative medicine for the treatment of neurodegenerative disorders, such as epilepsy. The overall objective of my PhD thesis was to set the stage to develop functional hippocampal brain organoid that can be used for regenerative medicine to cure the Temporal Lobe epilepsy (TLE)

Lo sviluppo dell'orticoltura biologica: la ricerca incontra il mondo operativo

Brochure - SUREVEG dissemination Open day in field for disseminating SUREVEG objectives and applied tools to local farmers and for discussing on advantages and limits of application of the strip-cropping system in organic vegetable production

Le nuove frontiere del biologico: la ricerca incontra il mondo operativo

La press release descrive la giornata rivolta ad agricoltori, tecnici, ricercatori, portatori di interesse, consumatori e appassionati di agricoltura. I ricercatori della Sede CREA OF di Monsampolo illustreranno i temi di fondo che animano le ricerche nazionali ed internazionali attualmente in atto, compreso il progetto SUREVEG, e che mirano ad ottenere protocolli agronomici per produzioni rispettose dell'ambiente, con elevate caratteristiche qualitative (sanitarie, organolettiche, nutrizionali e nutraceutiche) e che nello stesso tempo siano remunerativi del lavoro degli agricoltori

Le nuove frontiere del biologico: la ricerca incontra il mondo operativo

La press release descrive come i ricercatori della Sede CREA Centro di Ricerca Orticoltura e Florovivaismo di Monsampolo illustrano i temi di fondo che animano le ricerche nazionali ed internazionali attualmente in atto e che mirano ad ottenere protocolli agronomici per produzioni rispettose dell' ambiente, con elevate caratteristiche qualitative (sanitarie, organolettiche, nutrizionali e nutraceutiche) e che nello stesso tempo siano remunerativi del lavoro degli agricoltori. In tale contesto viene rappresentato, tra gli altri, anche il progetto SUREVEG, basato sull'applicazione dello strip-cropping in orticoltura biologica

Karakterizacija različitih obalnih područja Jadrana u kasno proljeće

The objective of this study is to analyze the physical and chemical characteristics of three coastal zones of the Adriatic Sea during late spring, and to identify similarities and differences among the zones. The trophic status of the Southeastern Adriatic-Sea, dominated by the discharge from the Buna/Bojana river delta watersheds, is compared with two other Adriatic regions: the Northwestern Adriatic Sea and the Southwestern Adriatic Sea (Gulf of Manfredonia); the first is dominated by the Po River freshwater discharge and the second is one of the most productive areas of the Southwestern Adriatic. The areas are influenced by two main Adriatic surface currents: the Eastern Adriatic Current (EAC) that flows north-westward, and the Western Adriatic Current (WAC) that flows south-eastward. The measurements of temperature, salinity, fluorescence, oxygen, nutrients and chlorophyll a in the three areas were collected and compared. The areas showed similar physical and bio-chemical characteristics, despite the Northern Adriatic is impacted by the Po River runoff and the WAC carries out along the Western Adriatic water rich of nutrients from the northern Italian rivers. The area affected by the Po River discharge showed maximum chlorophyll and nitrogen concentrations within the river plume. Moreover, the Southwestern Adriatic Sea showed a load of nutrients and organic matter connected to substances coming from the northern Italian rivers (mainly the Po River). Similarly, in the Southeastern Adriatic-Sea, the Buna/Bojana River discharge contained relatively high values in the regional chlorophyll distribution. The three areas are directly or indirectly linked to river plume dynamics and the associated inorganic and organic inputs determine the trophic state of the areas. In particular, the Southeastern Adriatic Sea was a meso-eutrophic area; despite the most eastern side of the Adriatic was an oligotrophic basin.Cilj ovog istraživanja je analiza fizikalnih i kemijskih svojstava triju obalnih područja Jadrana u kasno proljeće i ustanovljenje sličnosti i razlika među zonama. Trofički status jugoistočnog Jadran- skog mora, pod utjecajem dotoka slatke vode iz sliva rijeke Bune / Bojane, je u ovom radu uspoređen s druge dvije jadranske regije: sjeverozapadnim Jadranom i jugozapadnim Jadranom (zaljev Man -fredonia) u prvom dominiraju pražnjenja rijeke Po, dok je drugi jedno od najproduktivnijih područja jugozapadnog Jadrana. Područja su pod utjecajem dviju glavnih površinskih struja Jadranskog mora: istočne jadranske struje (EAC) koja teče prema sjeverozapadu i zapadne jadranske struja (WAC) koja teče prema jugo-istoku. podaci o izmjerenoj temperaturu, slanosti, fluorescenciji, kisiku, hranjivim tvarima i klorofilu a su sakupljeni i uspoređeni za sva tri područja. Istraživana područja su pokazala slične fizičke i bio-kemijske karakteristike, unatoč činjenici da je sjeverni Jadran pod utjecajem dotoka rijeke Po, a zapadna jadranska struja (WAC) nosi duž zapadnog Jadrana vodu bogatu hranjivim tvarima iz talijanskih rijeka na sjeveru. Područje pogođeno dotokom rijeke Po pokazalo je maksimum koncentracije klorofila i dušika unutar rijeka. Štoviše, u jugozapadnom Jadranu količina hranjivih tvari i organske tvari je povezana s tvarima koje dolaze iz sjevernih talijanskih rijeka (uglavnom rijeke po). Slično tome, u jugoistočnom dijelu jadranskog mora, dotok rijeke Bune / Bojane sadržavao je relativno visoke vrijednosti klorofila na nivou regionalne distribucije. Tri područja su izravno ili neizravno povezana s dinamikom riječnih perjanica, te organskim i anorganskim riječnim unosom koji određuje trofičko stanje područja. Konkretno, jugoistočno Jadransko more je mezo-eutrofično područje; unatoč većoj istočnoj strani Jadrana koij je bio oligotrofan bazen

MERCATI E COMPETITIVITÀ DI IMPRESA, NEWS CONVEGNO CREA “LE NUOVE FRONTIERE DEL BIOLOGICO: LA RICERCA INCONTRA IL MONDO OPERATIVO”

la press release presenta l’evento, rivolto ad agricoltori, tecnici, ricercatori, portatori di interesse, consumatori e appassionati di agricoltura che si svolgerà all’aperto presso i campi sperimentali della sede di Monsampolo. Nel corso della manifestazione, i ricercatori illustreranno gli studi attualmente in corso, finalizzati all’ottenimento di protocolli agronomici sostenibili che portino a produzioni remunerative per gli agricoltori e a prodotti con elevate caratteristiche qualitative

Variability of nutrient and thermal structure in surface waters between New Zealand and Antarctica, October 2004-January 2005

We describe the upper ocean thermal structure and surface nutrient concentrations between New Zealand and Antarctica along five transects that cross the Subantarctic Front, the Polar Front (PF) and the southern Antarctic Circumpolar Current (ACC) front. The surface water thermal structure is coupled with variations in surface nutrient concentrations, making water masses identifiable by both temperature and nutrient ranges. In particular, a strong latitudinal gradient in orthosilicate concentration is centred at the PF. On the earlier sections that extend south-west from the Campbell Plateau, orthosilicate increases sharply southward from 10–15 to 50–55 µmol l−1 between 58° S and 60° S, while surface temperature drops from 7°C to 2°C. Nitrate increases more regularly toward the south, with concentrations ranging from 10–12 µmol l−1 at 54° S to 25–30 µmol l−1 at 66° S. The same features are observed during the later transects between New Zealand and the Ross Sea, but the sharp silica and surface temperature gradients are shifted between 60° S and 64° S. Both temporal and spatial factors may influence the observed variability. The January transect suggests an uptake of silica, orthophosphate and nitrate between 63° S and 70° S over the intervening month, with an average depletion near 37%, 44% and 29%, respectively. An N/P (nitrite + nitrate/orthophosphate) apparent drawdown ratio of 8.8±4.1 and an Si/N (silicic acid/nitrite + nitrate) apparent drawdown ratio >1 suggest this depletion results from a seasonal diatom bloom. A southward movement of the oceanic fronts between New Zealand and the Ross Sea relative to prior measurements is consistent with reports of recent warming and changes in the ACC

Prostorna raspodjela fizikalnih, kemijskih i bioloških oceanografskih karakteristika, fitoplanktona, hranjivih tvari i otopljene obojane organske materije (CDOM) u Bokokotorskom zaljevu na Jadranu

The temporal variations of temperature, salinity, fluorescence, dissolved oxygen concentration, Coloured Dissolved Organic Matter (CDOM) and of chemical (nutrients, chlorophyll a) and biological (phytoplankton composition) parameters in the Boka Kotorska Bay were observed during two periods. CDOM regulates the penetration of UV light into the sea and therefore plays an important role in many hydrological and biogeochemical processes in the sea surface layer including primary productivity. In the framework ADRICOSM-STAR it was possible to investigate the Boka Kotorska Bay during May and June 2008 in order to increase an understanding of optical and chemical characteristics and their evolution during these periods. In both periods station KO (located furthest from the open sea) presented different physical, chemical and biological characteristics with respect to the other stations inside the Boka Kotorska Bay. A positive correlation was found between CDOM and chlorophyll a (R = 0.7, P < 0.001, n = 15) and this implies that in this area, similarly to the open sea, the primary source of CDOM should be the biological production from phytoplankton. This is probably due to the fact that the rivers entering the Boka Kotorska Bay are not severely impacted by man.U Bokokotorskom zaljevu su mjerene vremenske promjene temperature, saliniteta, fluorescencije, koncentracije otopljenog kisika, obojene otopljene organske materije (CDOM) i kemijskih (hranjive soli, klorofila) i bioloških (sastav fitoplanktona) parametara tijekom dva razdoblja (svibanj i lipanj 2008. godine). CDOM određuje prodiranje UV svjetlosnih zraka u more i stoga igra vrlo važnu ulogu u mnogim hidrološkim i biogeokemijskim procesima u površinskom sloju mora koji uključuje primarnu produkciju. Unutar ADRICOSM-STAR projekta, bilo je moguće istražiti Bokokotorski zaljev tijekom svibnja i lipnja 2008. godine radi povećanja razumijevanja optičkih i kemijskih karakteristika i njihovog razvoja kroz ova razdoblja. Zbog dotoka krških rijeka i smanjenja razmjene s otvorenim morem, u oba razdoblja postaja KO (smještena najdalje od otvorenog mora) je pokazala različite fizikalne, kemijske i biolo{ke karakteristike u odnosu na postaje unutar Bokokotorskog zaljeva. Pronađena je pozitivna korelacija izme|u CDOM i klorofila a (R = 0.7, P < 0.001, n = 15) {to upućuje na to da bi u ovom području, slično otvorenom moru, primarni izvor CDOM trebao biti biološka produkcija od fitoplanktona. To je vjerojatno zbog toga što dotoci rijeka u Bokokotorskom zaljevu nisu ozbiljnije ugroženi ljudskim djelovanjem

Karakterizacija različitih obalnih područja Jadrana u kasno proljeće

The objective of this study is to analyze the physical and chemical characteristics of three coastal zones of the Adriatic Sea during late spring, and to identify similarities and differences among the zones. The trophic status of the Southeastern Adriatic-Sea, dominated by the discharge from the Buna/Bojana river delta watersheds, is compared with two other Adriatic regions: the Northwestern Adriatic Sea and the Southwestern Adriatic Sea (Gulf of Manfredonia); the first is dominated by the Po River freshwater discharge and the second is one of the most productive areas of the Southwestern Adriatic. The areas are influenced by two main Adriatic surface currents: the Eastern Adriatic Current (EAC) that flows north-westward, and the Western Adriatic Current (WAC) that flows south-eastward. The measurements of temperature, salinity, fluorescence, oxygen, nutrients and chlorophyll a in the three areas were collected and compared. The areas showed similar physical and bio-chemical characteristics, despite the Northern Adriatic is impacted by the Po River runoff and the WAC carries out along the Western Adriatic water rich of nutrients from the northern Italian rivers. The area affected by the Po River discharge showed maximum chlorophyll and nitrogen concentrations within the river plume. Moreover, the Southwestern Adriatic Sea showed a load of nutrients and organic matter connected to substances coming from the northern Italian rivers (mainly the Po River). Similarly, in the Southeastern Adriatic-Sea, the Buna/Bojana River discharge contained relatively high values in the regional chlorophyll distribution. The three areas are directly or indirectly linked to river plume dynamics and the associated inorganic and organic inputs determine the trophic state of the areas. In particular, the Southeastern Adriatic Sea was a meso-eutrophic area; despite the most eastern side of the Adriatic was an oligotrophic basin.Cilj ovog istraživanja je analiza fizikalnih i kemijskih svojstava triju obalnih područja Jadrana u kasno proljeće i ustanovljenje sličnosti i razlika među zonama. Trofički status jugoistočnog Jadran- skog mora, pod utjecajem dotoka slatke vode iz sliva rijeke Bune / Bojane, je u ovom radu uspoređen s druge dvije jadranske regije: sjeverozapadnim Jadranom i jugozapadnim Jadranom (zaljev Man -fredonia) u prvom dominiraju pražnjenja rijeke Po, dok je drugi jedno od najproduktivnijih područja jugozapadnog Jadrana. Područja su pod utjecajem dviju glavnih površinskih struja Jadranskog mora: istočne jadranske struje (EAC) koja teče prema sjeverozapadu i zapadne jadranske struja (WAC) koja teče prema jugo-istoku. podaci o izmjerenoj temperaturu, slanosti, fluorescenciji, kisiku, hranjivim tvarima i klorofilu a su sakupljeni i uspoređeni za sva tri područja. Istraživana područja su pokazala slične fizičke i bio-kemijske karakteristike, unatoč činjenici da je sjeverni Jadran pod utjecajem dotoka rijeke Po, a zapadna jadranska struja (WAC) nosi duž zapadnog Jadrana vodu bogatu hranjivim tvarima iz talijanskih rijeka na sjeveru. Područje pogođeno dotokom rijeke Po pokazalo je maksimum koncentracije klorofila i dušika unutar rijeka. Štoviše, u jugozapadnom Jadranu količina hranjivih tvari i organske tvari je povezana s tvarima koje dolaze iz sjevernih talijanskih rijeka (uglavnom rijeke po). Slično tome, u jugoistočnom dijelu jadranskog mora, dotok rijeke Bune / Bojane sadržavao je relativno visoke vrijednosti klorofila na nivou regionalne distribucije. Tri područja su izravno ili neizravno povezana s dinamikom riječnih perjanica, te organskim i anorganskim riječnim unosom koji određuje trofičko stanje područja. Konkretno, jugoistočno Jadransko more je mezo-eutrofično područje; unatoč većoj istočnoj strani Jadrana koij je bio oligotrofan bazen

Seminário de estudos sobre restauração arquitetônica: "temas recentes no restauro na Itália", FAU - Maranhão

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