495 research outputs found
On admissibility criteria for weak solutions of the Euler equations
We consider solutions to the Cauchy problem for the incompressible Euler
equations satisfying several additional requirements, like the global and local
energy inequalities. Using some techniques introduced in an earlier paper we
show that, for some bounded compactly supported initial data, none of these
admissibility criteria singles out a unique weak solution.
As a byproduct we show bounded initial data for which admissible solutions to
the p-system of isentropic gas dynamics in Eulerian coordinates are not unique
in more than one space dimension.Comment: 33 pages, 1 figure; v2: 35 pages, corrected typos, clarified proof
Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage.
Dissipative continuous Euler flows
We show the existence of continuous periodic solutions of the 3D
incompressible Euler equations which dissipate the total kinetic energy
The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer.
Quantitative evaluation of somatostatin receptor subtype 2 expression in sporadic colorectal tumor and in the corresponding normal mucosa.
Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar
O Helicobacter pylori Ă© uma bactĂ©ria reconhecida como a principal causa de Ăşlcera pĂ©ptica e gastrite crĂ´nica. Recentemente, o proteoma do H. pylori tem sido desenvolvido visando identificar fatores patogĂŞnicos relacionados ao microorganismo. Neste estudo preliminar, cepas de H. pylori foram isoladas de fragmento de mucosa gástrica de pacientes com Ăşlcera duodenal e gastrite crĂ´nica. Posteriormente, realizou-se uma análise proteĂ´mica parcial dessas cepas, atravĂ©s da lise bacteriana e da separação de proteĂnas atravĂ©s da eletroforese de duas dimensões (2-DE). Por análise comparativa, foi possĂvel verificar a expressĂŁo protĂ©ica diferencial entre os dois mapas 2-DE obtidos. Os dados poderĂŁo ser Ăşteis para esclarecer a importância de diferentes proteĂnas relacionadas Ă patogĂŞnese da bactĂ©ria. Este estudo será complementado utilizando um maior nĂşmero de amostras e a identificação protĂ©ica do H. pylori atravĂ©s da espectrometria de massa do tipo MALDI-TOF.Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patients with chronic gastritis and duodenal ulcers. A partial proteomic analysis of H. pylori strains was performed by bacterial lyses and proteins were separated by two-dimensional gel electrophoresis (2-DE). A comparative analysis was performed to verify a differential protein expression between these two 2-DE maps. These data should be useful to clarify the role of different proteins related to bacterial pathogenesis. This study will be completed using a larger number of samples and protein identification of H. pylori by MALDI-TOF mass spectrometry
DNA methylation profiling reveals common signatures of tumorigenesis and defines epigenetic prognostic subtypes of canine Diffuse Large B-cell Lymphoma
Epigenetic deregulation is a hallmark of cancer characterized by frequent acquisition of new DNA methylation in CpG islands. To gain insight into the methylation changes of canine DLBCL, we investigated the DNA methylome in primary DLBCLs in comparison with control lymph nodes by genome-wide CpG microarray. We identified 1,194 target loci showing different methylation levels in tumors compared with controls. The hypermethylated CpG loci included promoter, 5'-UTRs, upstream and exonic regions. Interestingly, targets of polycomb repressive complex in stem cells were mostly affected suggesting that DLBCL shares a stem cell-like epigenetic pattern. Functional analysis highlighted biological processes strongly related to embryonic development, tissue morphogenesis and cellular differentiation, including HOX, BMP and WNT. In addition, the analysis of epigenetic patterns and genome-wide methylation variability identified cDLBCL subgroups. Some of these epigenetic subtypes showed a concordance with the clinical outcome supporting the hypothesis that the accumulation of aberrant epigenetic changes results in a more aggressive behavior of the tumor. Collectively, our results suggest an important role of DNA methylation in DLBCL where aberrancies in transcription factors were frequently observed, suggesting an involvement during tumorigenesis. These findings warrant further investigation to improve cDLBCL prognostic classification and provide new insights on tumor aggressiveness
Civil Security and the European Union: A survey of European civil security systems and the role of the EU in building shared crisis management capacities
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