European Parliament Pilot Project on Exposure to Indoor air Chemicals and Possible Health Risks

This report outlines the results of the 2-year pilot project on indoor air quality and potential health effects executed by the Joint Research Centre and funded by the European Parliament via the Directorate-General Health and Consumer Protection. It had four distinct objectives as follows: 1) to identify and quantify the main air pollutants present in public buildings, including indoor environments where children frequently stay, like schools and kindergartens, 2) to identify the main sources of these pollutants, applying source apportionment analyses, 3) to estimate people¿s exposure to these pollutants while working and/or living in these areas and combined with micro-environmental activity patterns during the day, 4) to evaluate possible health risks due to (chronic) exposure to air pollutants, in particular, for children. The results indicate that indoor air pollution concentrations are consistently higher than the respective outdoor ones for the chemical families this study focused on. Differences attributable to variation in consumer behaviour, climate and type of building materials used, have been identified in the indoor:outdoor ratio of primary pollutants across Europe. These differences account for small variance in the corresponding health risk to the local population across the EU.JRC.I.5-Physical and chemical exposure

Nest Change and Individual Fitness in a Scopoli’s Shearwater Population: A Capture-Recapture Multistate Analysis

Seabirds are compelled to nest on land, away from their feeding areas, which they can only reach by leaving eggs or chicks in the nest, often for long periods of time. For this reason, almost all of them have evolved social monogamy as a reproductive system, cooperation between partners for incubation and chick rearing, and long-lasting pair bonds. Additionally, nesting conditions are essential for successful reproduction, and the nest can be considered a resource if it provides more guarantees in this aspect. As a result, the nest may be a source of contention and intraspecific competition, especially among males. In this work, we analyze long-term data of the Scopoli’s shearwater (Calonectris diomedea) population to address the fitness consequences of nest change regarding survival and reproductive success. We used capture–recapture multistate models and the AICc model selection approach to test three hypotheses: breeding failure triggers nest change; nest change affects breeding success probability; nest change affects survival. Each year, about 5% of the breeders move to a new nest. For males, it was mainly a way to improve their breeding conditions and was observed in their early years as a breeder. Conversely, for females, it was a way to improve their reproductive performance by trying with a new mate after a failure. Males that changed nests improved their breeding success probability. Instead, in females, there was no causal relation between nest change and breeding success, the latter having been more influenced by the intrinsic quality of the female as a breeder. We did not even find a link between nest change and survival. Instead, we demonstrated that reproductive failure could affect the apparent survival of females, probably because it induces breeding dispersal

Control of invasive species for the conservation of biodiversity in Mediterranean islands. The LIFE PonDerat project in the Pontine Archipelago, Italy

We present the EU LIFE PonDerat project, which is aimed at restoring the natural ecosystems of the Pontine Archipelago, a group of islands located off the western coast of Italy. The spread of invasive species is a major environmental threat on these islands, which are rich in rare habitats and endemic species and are important sites for the conservation of Mediterranean biodiversity. The project focuses on the conservation of species and habitats that are protected by EU laws but are currently threatened by introduced plants and animals. The main targets of the control measures are black rats, feral goats, mouflons and invasive plants of the genus Carpobrotus. Conservation measures focus on the shearwaters Puffinus yelkouan and Calonectris diomedea, which are endemic to the Mediterranean and are listed in Annex I of the European Bird Directive. Conservation measures also focus on island habitats of great biogeographical value, which are listed in Annex I of the European Habitats Directive and are seriously threatened by introduced herbivores and by invasive plants. The main outcome expected from this project is that the restoration of ecosystem functions will enhance the breeding success and population size of shearwaters and lead to the recovery of target habitats

The frequency of rare and monogenic diseases in pediatric organ transplant recipients in Italy

Background: Rare diseases are chronic and life-threatening disorders affecting < 1 person every 2,000. For most of them, clinical symptoms and signs can be observed at birth or childhood. Approximately 80% of all rare diseases have a genetic background and most of them are monogenic conditions. In addition, while the majority of these diseases is still incurable, early diagnosis and specific treatment can improve patients' quality of life. Transplantation is among the therapeutic options and represents the definitive treatment for end-stage organ failure, both in children and adults. The aim of this paper was to analyze, in a large cohort of Italian patients, the main rare genetic diseases that led to organ transplantation, specifically pointing the attention on the pediatric cohort. Results: To the purpose of our analysis, we considered heart, lung, liver and kidney transplants included in the Transplant Registry (TR) of the Italian National Transplantation Center in the 2002-2019 timeframe. Overall, 49,404 recipients were enrolled in the cohort, 5.1% of whom in the pediatric age. For 40,909 (82.8%) transplant recipients, a disease diagnosis was available, of which 38,615 in the adult cohort, while 8,495 patients (17.2%) were undiagnosed. There were 128 disease categories, and of these, 117 were listed in the main rare disease databases. In the pediatric cohort, 2,294 (5.6%) patients had a disease diagnosis: of the 2,126 (92.7%) patients affected by a rare disease, 1,402 (61.1%) presented with a monogenic condition. As expected, the frequencies of pathologies leading to organ failure were different between the pediatric and the adult cohort. Moreover, the pediatric group was characterized, compared to the adult one, by an overall better survival of the graft at ten years after transplant, with the only exception of lung transplants. When comparing survival considering rare vs non-rare diseases or rare and monogenic vs rare non-monogenic conditions, no differences were highlighted for kidney and lung transplants, while rare diseases had a better survival in liver as opposed to heart transplants. Conclusions: This work represents the first national survey analyzing the main genetic causes and frequencies of rare and/or monogenic diseases leading to organ failure and requiring transplantation both in adults and children

Search for Bc+→π+μ+μ−B_c^+\to\pi^+\mu^+\mu^- decays and measurement of the branching fraction ratio B(Bc+→ψ(2S)π+)/B(Bc+→J/ψπ+){\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)

International audienceThe first search for nonresonant $B_c^+\to\pi^+\mu^+\mu^-$ decays is reported. The analysis uses proton-proton collision data collected with the LHCb detector between 2011 and 2018, corresponding to an integrated luminosity of 9 fb$^{-1}$. No evidence for an excess of signal events over background is observed and an upper limit is set on the branching fraction ratio ${\cal B}(B_c^+\to\pi^+\mu^+\mu^-)/{\cal B}(B_c^+\to J/\psi \pi^+) < 2.1\times 10^{-4}$ at $90\%$ confidence level. Additionally, an updated measurement of the ratio of the $B_c^+\to\psi(2S)\pi^+$ and $B_c^+\to J/\psi \pi^+$ branching fractions is reported. The ratio ${\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)$ is measured to be $0.254\pm 0.018 \pm 0.003 \pm 0.005$, where the first uncertainty is statistical, the second systematic, and the third is due to the uncertainties on the branching fractions of the leptonic $J/\psi$ and $\psi(2S)$ decays. This measurement is the most precise to date and is consistent with previous LHCb results

Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using $pp$ collision data at $\sqrt{s}=13\,{\rm TeV}$ recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of $5.5\,{\rm fb}^{-1}$. A total of around $10^5$ helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately $50\%$ with a corresponding background rejection rate of up to $\mathcal O(10^{12})$. These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Study of Bc+→χcπ+B_c^+ \rightarrow \chi_c \pi^+ decays

International audienceA study of $B_c^+ \rightarrow \chi_c \pi^+$ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9fb$^{-1}$. The decay $B_c^+ \rightarrow \chi_{c2} \pi^+$ is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the $B_c^+ \rightarrow J/\psi \pi^+$ decay is measured to be $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow J/\psi \pi^+}} = 0.37 \pm 0.06 \pm 0.02 \pm 0.01 ,$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the knowledge of the $\chi_c \rightarrow J/\psi \gamma$ branching fraction. No significant $B_c^+ \rightarrow \chi_{c1} \pi^+$ signal is observed and an upper limit for the relative branching fraction for the $B_c^+ \rightarrow \chi_{c1} \pi^+$ and $B_c^+ \rightarrow \chi_{c2} \pi^+$ decays of $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c1} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} < 0.49$$ is set at the 90% confidence level

Observation of Λb0→Λc+Dˉ(∗)0K−\Lambda_{b}^{0} \to \Lambda_{c}^{+} \bar{D}^{(*)0} K^{-} and Λb0→Λc+Ds∗−\Lambda_{b}^{0} \to \Lambda_{c}^{+} D_{s}^{*-} decays

International audienceThe decays $\Lambda_b^0 \to \Lambda_c^+\bar{D}^{(*)0}K^-$ and $\Lambda_b^0 \to \Lambda_c^+ D_s^{*-}$ are observed for the first time, in proton-proton collision data at $\sqrt{s}=13$TeV corresponding to an integrated luminosity of 5.4 fb${}^{-1}$ collected with the LHCb detector. Their ratios of branching fractions with respect to the $\Lambda_b^0\!\to\Lambda_c^+\mathrm{D}_s^-$ mode are measured to be \begin{align*} \begin{split} \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^0 K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.1908 {}_{-0.0034}^{+0.0036} {}_{-0.0018}^{+0.0016} \pm 0.0038 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^{*0} K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.589 {}_{-0.017}^{+0.018} {}_{-0.018}^{+0.017} \pm 0.012 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^{*-})}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 1.668 \pm 0.022 {}_{-0.055}^{+0.061}\ , \end{split} \end{align*} where the first uncertainties are statistical, the second systematic, and the third, for the $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0} K^-$ decays, are due to the uncertainties on the branching fractions of the $D_s^- \to K^- K^+ \pi^-$ and $\bar{D}^0 \to K^+\pi^-$ decay modes. The measured branching fractions probe factorization assumptions in effective theories and provide the normalization for future pentaquark searches in $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0}K^-$ decay channels

Determination of short- and long-distance contributions in B0→K∗0μ+μ−B^{0}\to K^{*0}\mu^+\mu^- decays

International audienceAn amplitude analysis of the $B^0 \to K^{*0} \mu^+\mu^-$ decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at $\sqrt{s} = 7,\,8$ and $13$ TeV, corresponding to an integrated luminosity of $4.7$ fb$^{-1}$. For the first time, Wilson coefficients and non-local hadronic contributions are accessed directly from the unbinned data, where the latter are parameterised as a function of $q^2$ with a polynomial expansion. Wilson coefficients and non-local hadronic parameters are determined under two alternative hypotheses: the first relies on experimental information alone, while the second one includes information from theoretical predictions for the non-local contributions. Both models obtain similar results for the parameters of interest. The overall level of compatibility with the Standard Model is evaluated to be between 1.8 and 1.9 standard deviations when looking at the $\mathcal{C}_9$ Wilson coefficient alone, and between 1.3 and 1.4 standard deviations when considering the full set of $\mathcal{C}_9, \, \mathcal{C}_{10}, \, \mathcal{C}_9^\prime$ and $\mathcal{C}_{10}^\prime$ Wilson coefficients. The ranges reflect the theoretical assumptions made in the analysis