Aliphatic polyester polymer stars: synthesis, properties and applications in biomedicine and nanotechnology

abstract: A critical review: the ring-opening polymerization of cyclic esters provides access to an array of biodegradable, bioassimilable and renewable polymeric materials. Building these aliphatic polyester polymers into larger macromolecular frameworks provides further control over polymer characteristics and opens up unique applications. Polymer stars, where multiple arms radiate from a single core molecule, have found particular utility in the areas of drug delivery and nanotechnology. A challenge in this field is in understanding the impact of altering synthetic variables on polymer properties. We review the synthesis and characterization of aliphatic polyester polymer stars, focusing on polymers originating from lactide, epsilon-caprolactone, glycolide, beta-butyrolactone and trimethylene carbonate monomers and their copolymers including coverage of polyester miktoarm star copolymers. These macromolecular materials are further categorized by core molecules, catalysts employed, self-assembly and degradation properties and the resulting fields of application (262 references)

Tacticity Control in the Synthesis of Poly(lactic acid) Polymer Stars with Dipentaerythritol Cores

The synthesis of a family of polymer stars with arms of varied tacticities is discussed. The effect of polymer tacticity on the physical properties of these polymer stars is presented. Dipentaerythritol cores support six poly(lactic acid) (PLA) arms. Lewis acidic tin and aluminum catalysts control the polymerization to afford polymer stars of variable tacticity. The analysis of these polymers by NMR spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and differential scanning calorimetry reveals the effects of tacticity control on the physical properties of the polymer stars. Preliminary decomposition studies suggest that the biodegradation profile of a polymer star may also be tuned by stereochemical control. This is the first systematic altering of tacticity in PLA polymer stars, showing that polymer tacticity can have a great impact on star properties.PT: J; UT: BIOSIS:PREV20110005905

What Will it Take to Make Solar Panels Cool?

With the predicted results of climate change looming, humanity must do all it can to limit greenhouse gas emissions. Maintaining a habitable environment along with the high quality of living associated with developed nations requires investment in renewable energy. Because national governments often fail to make responsible decisions for their country\u27s future, this burden falls to institutions like UMass Amherst. Although costly investments like solar panels substantially improve the sustainability of campus, some innovative improvements of existing solar energy infrastructure can go a long way. For example, when solar panels heat up they lose photovoltaic efficiency. We propose that UMass institute cooling systems on current and future solar panel structures. This may sound extravagant, but in this paper we outline a plan for a simple and affordable cooling system that can be constructed from supplies bought at a local hardware store. The University spent approximately $1.5 million dollars on the new solar canopy atop the Robsham’s Visitor Center. This structure generates an estimated$40,000 worth of electricity each year, with a 38 year return on investment. We expect a cooling system for each canopy to cost around $500 and to improve power output by more than 10 percent. This means that by the most conservative estimate, a$500 investment will generate an additional $4,000 worth of electricity, reducing the return on investment time by 4 years. Compared with the initial solar canopy investment, this magnitude of electricity generation would have cost$150,000. By comparison, $500 is peanuts. Read on to see how a little ingenuity can go a long way to save money and the environment

Angular Momentum Evolution of Stars in the Orion Nebula Cluster

(Abridged) We present theoretical models of stellar angular momentum evolution from the Orion Nebula Cluster (ONC) to the Pleiades and the Hyades. We demonstrate that observations of the Pleiades and Hyades place tight constraints on the angular momentum loss rate from stellar winds. The observed periods, masses and ages of ONC stars in the range 0.2--0.5 M$_\odot$, and the loss properties inferred from the Pleiades and Hyades stars, are then used to test the initial conditions for stellar evolution models. We use these models to estimate the distribution of rotational velocities for the ONC stars at the age of the Pleiades (120 Myr). The modeled ONC and observed Pleiades distributions of rotation rates are not consistent if only stellar winds are included. In order to reconcile the observed loss of angu lar momentum between these two clusters, an extrinsic loss mechanism such as protostar-accretion disk interaction is required. Our model, which evolves the ONC stars with a mass dependent saturation threshold normalized such that $\omega_{crit} = 5.4 \omega_\odot$ at 0.5 \m, and which includes a distribution of disk lifetimes that is uniform over the range 0--6 Myr, is consistent with the Pleiades. This model for disk-locking lifetimes is also consistent with inferred disk lifetimes from the percentage of stars with infrared excesses observed in young clusters. Different models, using a variety of initial period distributions and different maximum disk lifetimes, are also compared to the Pleiades. For disk-locking models that use a uniform distribution of disk lifetimes over the range 0 to $\tau_{max}$, the acceptable range of the maximum lifetime is $3.5 < \tau_{max} < 8.5$ Myr.Comment: 21 pages, 7 figures, submitted to Ap

Metagenomics, gene discovery and the ideal biocatalyst

With the rapid development of powerful protein evolution and enzyme-screening technologies, there is a growing belief that optimum conditions for biotransformation processes can be established without the constraints of the properties of the biocatalyst. These technologies can then be applied to find the ‘ideal biocatalyst’ for the process. In identifying the ideal biocatalyst, the processes of gene discovery and enzyme evolution play major roles. However, in order to expand the pool genes for in vitro evolution, new technologies, which circumvent the limitations of microbial culturability, must be applied. These technologies, which currently include metagenomic library screening, gene-specific amplification methods and even full metagenomic sequencing, provide access to a volume of ‘sequence space’ that is not addressed by traditional screening

Rotational velocities of low-mass stars in the Pleiades and Hyades

We have obtained high-resolution spectra of 89 M dwarf members of the Pleiades and Hyades and have derived radial velocities, H-alpha equivalent widths, and spectroscopic rotational velocities for these stars. Typical masses of the newly-observed Pleiades and Hyades stars are ~ 0.4 M_{\sun} and ~ 0.2 M_{\sun}, respectively. We combine our new observations with previously published data to explore the rotational evolution of young stars with M < 0.4 M_\sun. The average rotation rate in the Hyades (age 600 Myr) is about 0.4 that of the Pleiades (110 Myr), and the mean equivalent widths of H-alpha are also lower. As found in previous studies, the correlation between rotation and chromospheric activity is identical in both clusters, implying that the lower activity in the Hyades is a result of the lower rotation rates. We show that a simple scaling of the Pleiades rotational distribution for M \leq 0.4 M_{\sun}, corrected for the effects of structural evolution, matches that of the Hyades if the average angular momentum loss from the Pleiades to the Hyades age is factor of \approx 6. This suggests that the distribution of initial angular momenta and disk-locking lifetimes for the lowest mass stars was similar in both clusters. We argue that this result provides further evidence for a saturation of the angular momentum loss rate at high rotational velocities.Comment: 22 pages, 11 figures, accepted for publication in The Astronomical Journal, tentatively scheduled for March 200

The clustering of Galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : including covariance matrix errors

JP acknowledges support from the UK Science & Technology Facilities Council (STFC) through the consolidated grant ST/K0090X/1 and from the European Research Council through the ‘Starting Independent Research’ grant 202686, MDEPUGS. AGS acknowledges support from the Trans-regional Collaborative Research Centre TR33 ‘The Dark Universe’ of the German Research Foundation (DFG).We present improved methodology for including covariance matrices in the error budget of Baryon Oscillation Spectroscopic Survey (BOSS) galaxy clustering measurements, revisiting Data Release 9 (DR9) analyses, and describing a method that is used in DR10/11 analyses presented in companion papers. The precise analysis method adopted is becoming increasingly important, due to the precision that BOSS can now reach: even using as many as 600 mock catalogues to estimate covariance of two-point clustering measurements can still lead to an increase in the errors of ∼20 per cent, depending on how the cosmological parameters of interest are measured. In this paper, we extend previous work on this contribution to the error budget, deriving formulae for errors measured by integrating over the likelihood, and to the distribution of recovered best-fitting parameters fitting the simulations also used to estimate the covariance matrix. Both are situations that previous analyses of BOSS have considered. We apply the formulae derived to baryon acoustic oscillation (BAO) and redshift-space distortion (RSD) measurements from BOSS in our companion papers. To further aid these analyses, we consider the optimum number of bins to use for two-point measurements using the monopole power spectrum or correlation function for BAO, and the monopole and quadrupole moments of the correlation function for anisotropic-BAO and RSD measurements.Publisher PDFPeer reviewe