THE RURAL DEVELOPMENT PROGRAMS 2007-13 OF THE ITALIAN REGIONS A QUALI-QUANTITATIVE ANALYSIS

This paper presents a preliminary evaluation of the 21 Rural Development Programs (RDPs) of the Italian regions and Autonomous provinces. A quantitative analysis of the Italian RDPs will be carried out investigating the distribution of the European Agricultural Funds for Rural Development, considering national and regional co-financing, in order to highlight the different allocation of funds between axes and measures across the regions. To support quantitative analysis a qualitative investigation, and related methodology, will be presented and applied to three Italian regions. This combined methodology allows a gathering of different aspects of rural development policy, thus to reveal the objectives pursued by the regions often hidden “between the lines” of the RDP texts.Rural development policy, Italian regions, Evaluation of efficiency and Effectiveness, In progress support to policy decisions, Agricultural and Food Policy, Q18, Q19,

Cumulus extracellular matrix is an important part of oocyte microenvironment in ovarian follicles: its remodeling and proteolytic degradation

The extracellular matrix (ECM) is an essential structure with biological activities. It has been shown that the ECM influences gene expression via cytoskeletal components and the gene expression is dependent upon cell interactions with molecules and hormones. The development of ovarian follicles is a hormone dependent process. The surge in the luteinizing hormone triggers ovulatory changes in oocyte microenvironment. In this review, we discuss how proteolytic cleavage affects formation of cumulus ECM following hormonal stimulation; in particular, how the specific proteasome inhibitor MG132 affects gonadotropin-induced cytoskeletal structure, the organization of cumulus ECM, steroidogenesis, and nuclear maturation. We found that after the inhibition of proteolytic cleavage, gonadotropin-stimulated oocyte–cumulus complexes (OCCs) were without any signs of cumulus expansion; they remained compact with preserved cytoskeletal F-actin-rich transzonal projections through the oocyte investments. Concomitantly, a significant decrease was detected in progesterone secretion and in the expression of gonadotropin-stimulated cumulus expansion–related transcripts, such as HAS2 and TNFAIP6. In agreement, the covalent binding between hyaluronan and the heavy chains of serum-derived the inter-alpha-trypsin inhibitor, essential for the organization of cumulus ECM, was missing

Oracular Byzantine Reliable Broadcast

Byzantine Reliable Broadcast (BRB) is a fundamental distributed computing primitive, with applications ranging from notifications to asynchronous payment systems. Motivated by practical consideration, we study Client-Server Byzantine Reliable Broadcast (CSB), a multi-shot variant of BRB whose interface is split between broadcasting clients and delivering servers. We present Draft, an optimally resilient implementation of CSB. Like most implementations of BRB, Draft guarantees both liveness and safety in an asynchronous environment. Under good conditions, however, Draft achieves unparalleled efficiency. In a moment of synchrony, free from Byzantine misbehaviour, and at the limit of infinitely many broadcasting clients, a Draft server delivers a b-bits payload at an asymptotic amortized cost of 0 signature verifications, and (log?(c) + b) bits exchanged, where c is the number of clients in the system. This is the information-theoretical minimum number of bits required to convey the payload (b bits, assuming it is compressed), along with an identifier for its sender (log?(c) bits, necessary to enumerate any set of c elements, and optimal if broadcasting frequencies are uniform or unknown). These two achievements have profound practical implications. Real-world BRB implementations are often bottlenecked either by expensive signature verifications, or by communication overhead. For Draft, instead, the network is the limit: a server can deliver payloads as quickly as it would receive them from an infallible oracle

Creating social connections in higher education: insights from the Campus Canines Program at the University of Pittsburgh

The overall purpose of this study was to capture the relationships made during the Campus Canines Program, an animal-assisted activity program, at the University of Pittsburgh. Meaningful social relationships create greater educational satisfaction. These social relationships are an important piece to creating and sustaining student involvement, and therefore retention, in a college environment. Therefore, the current study is significant because Campus Canines Program may be a program that fosters these important relationships for students. This study used a case study approach that included two mixed-method online instruments. Both surveys are comprised of close-ended quantitative questions and open-ended qualitative questions. During the 2012 Spring Academic Term, a census of the entire population was conducted. This census determined the entire student population to be 270 and volunteer population to be 20. The canine population of 22 was also determined but only for informational purposes. All 270 students were selected for this study and 69 responded to the survey with a 25.5% response rate. All 20 volunteers were selected to participate in this study and 11 responded to the survey with a 55% response rate. Overall, the results suggest that the Campus Canines Program does create a program for student involvement and may support established relationships. The key findings include (1) the dogs may aid in communication with other participants, (2) the program specifically supports established relationships between friends and family, and (3) the Campus Canine Program may provide stress relief. In the first key finding, the dogs act as a social stimulant. This supports the literature that states animals provide a safe environment to promote communication between people. The second key finding shows that the Campus Canines Program specifically supports established relationships between friends and family. These results support the literature which indicates that the human-animal relationship may aid in the development of social networks. Lastly, the third key finding shows that stress relief is a benefit of this program. This does support the literature that states interaction with animals produces physiological benefits

Physico-Chemical Properties Mediating Reproductive and Developmental Toxicity of Engineered Nanomaterials

With the increasing production of engineered nanomaterials (ENMs) exploited in many consumer products, a wider number of people is expected to be exposed to such materials in the near future, both in occupational and environmentalsettings. This has raised concerns about the possible implications on public health. In particular, very recently the scientific community has focused on the effect that ENMs might exert on the reproductive apparatus and on embryonic development. Indications that ENMs might have adverse effects on cells of the germ line and on the developing embryos have been reported. In the present minireview we will perform a critical analysis of the published work on reproductive and developmental toxicity of the most commonly used nanoparticles with a major focus on mammalian models. We will place emphasis on the main physico-chemical characteristics that can affect NP behaviour in biological systems, i.e. presence of contaminants and nanoparticle destabilization, size, dosage, presence of functional groups, influence of the solvent used for their suspension in biological media, aggregation/agglomeration, intrinsic chemical composition and protein corona/opsonisation. The importance of this specific field of nanotoxicology is documented by the rapidly increasing number of published papers registered in the last three years, which might be a consequence of the growing concerns on the possible interference of ENMs with reproductive ability and pregnancy outcome, in a time in which reproductive age has increased and the possibility to bear children appears reduced

Carbon: An Asynchronous Voting-Based Payment System for a Client-Server Architecture

We present Carbon, an asynchronous payment system. To the best of our knowledge, Carbon is the first asynchronous payment system designed specifically for a client-server architecture. Namely, besides being able to make payments, clients of Carbon are capable of changing the set of running servers using a novel voting mechanism -- asynchronous, balance-based voting

Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells

In the last two decades, considerable progress has been made in the derivation of mammalian germ cells from pluripotent stem cells such as Embryonic Stem Cells (ESCs) and induced Pluripotent Stem Cells (iPSCs). The pluripotent stem cells are generally first induced into pre-gastrulating endoderm/mesoderm-like status and then specified into putative primordial germ cells (PGCs) termed PGC-like cells (PGCLCs) which possess the potential to generate oocytes and sperms. Adipose-derived mesenchymal stromal cells (ASCs) are multipotent cells, having the capacity to differentiate into cell types such as adipocytes, osteocytes and chondrocytes. Since no information is available about the capability of female human ASCs (hASCs) to generate PGCLCs, we compared protocols to produce such cells from hASCs themselves or from hASC-derived iPSCs. The results showed that, providing pre-induction into a peri-gastrulating endoderm/mesoderm-like status, hASCs can generate PGCLCs. This process, however, shows a lower efficiency than when hASC-derived iPSCs are used as starting cells. Although hASCs possess multipotency and express mesodermal genes, direct induction into PGCLCs resulted less efficient

Water activated ionic conduction in cross-linked polyelectrolytes

The electrical properties of polyelectrolytes depend on the water concentration of the environment. The behaviour of both conductance and capacitance caused by variations in relative humidity and temperature was investigated by impedance spectroscopy for humidity sensors based on an interpenetrated network of a polymer and a polyelectrolyte. The results were interpreted on the base of the Langmuir and Kelvin equations and two different sensing mechanisms were highlighted for low and high water content

Impaired postural control in patients affected by tension-type headache.

Sixteen subjects, affected by chronic tension-type headache (TTH) accordingly to the International Headache Society Classification (1988) criteria, in presence of tenderness in pericranial muscles,with a mean age of 37+/-11.8 years, and ten healthy volunteer subjects, age and sex matched, were submitted to postural analysis by Static Posturography (S.Ve.P. Amplaid). Aim of the study was to evaluate whether patients with TTH have disturbed postural control, as compared to normal subjects. Postural analysis considered all posturographic variables but focused on spectral frequency analysis of body sway. In both open (OE) and closed eyes (CE) condition, spectral frequency analysis showed a significantly increased body sway at low (OE= p < or = 0.01; CE= p < or = 0.01) and middle (OE= p < or = 0.01; CE= p < or = 0.01) frequencies on the antero-posterior (y) plane and at low frequencies (OE= p < or = 0.05; CE= p < or = 0.05) on the lateral (x) plane. Statistical analysis was performed using the Student's t test for unpaired data, p value 0.05 defined significant. The proprioceptive input seems to be predominant at middle and high frequencies in maintaining posture, our results seem then to suggest a proprioceptive disturbance in TTH patients. The disturbance is likely related to chronic pericranial muscle contraction and tenderness. Posturography and spectral analysis may help not only in the diagnosis of a postural disturbance but even more in the follow-up of TTH patients, during and after a medical and/or a rehabilitative treatment