Diferencias electroencefalográficas en niños con dos subtipos del trastorno por deficit de atención con hiperactividad.

Los estudios electroencefalográficos en niños con Trastorno por déficit de atención con Hiperactividad (TDAH) reportan perfiles específicos en diferentes subtipos del trastorno. Este estudio investiga la presencia de alteraciones electroencefalográficas en un grupo de niños del subtipo hiperactivo/impulsivo y combinado. Se estudiaron 15 niños del subtipo hiperactivo/impulsivo y 15 del combinado del TDAH a los que se les realizó un electroencefalograma en vigilia. Los principales hallazgos al electroencefalograma fueron el incremento de la actividad lenta frontal y la presencia de descargas epileptiformes en ambos grupos. Se encontraron diferencias significativas entre los espectros de frecuencia de ambos grupos, por exceso en las bandas lentas y por defecto en las rápidas en el hiperactivo/impulsivo respecto al combinado. Estos resultados respaldan el modelo de un déficit de maduración del Sistema Nervioso Central como base del TDAH. Palabras clave: Déficit de atención, Electroencefalografía, Electrofisiología. </p

El departamento de Biblioteconomía y Documentación de la UC3M obtiene el primer premio en el iSchools Video Contest

Audiovisuales: Enlace a video premiado disponible en Youtube en: https://youtu.be/FH9qDuU-5eg . -- Entrevista a Ana Reyes Pacios disponible en Youtuve en: https://youtu.be/CBLeH9-PRyI . -- Entrevista a Javier Calzada disponible en Youtube en: https://www.youtube.com/watch?v=ka-NiKPWpeYContiene: Entrevista a Ana Reyes Pacios (p. 4) . -- Entrevista a Javier Calzada (p. 4) . -- Entrevista a Virgina Ortiz-Repiso (p. 5

Voluntary Transparency in Spanish University Archives

Objetivo. Se presenta el índice de transparencia en publicidad activa obtenido mediante la aplicación TransPa_BA a la información relacionada con la transparencia disponible en las páginas web de 45 archivos de las universidades públicas españolas. Diseño/Metodología/Enfoque. Se utiliza la herramienta TransPa_BA que se inspira y utiliza parámetros de la Metodología de Evaluación y Seguimiento de la Transparencia (MESTA). Cuenta con 22 indicadores para la medición de la publicidad activa en los archivos que atienden a los requerimientos de la Ley de Transparencia española. Resultados/Discusión. Los resultados obtenidos indican que, aunque hay ejemplos de buenas prácticas, la información relacionada con la transparencia aún es escasa. Los puntos fuertes identificados se corresponden con el directorio, la normativa de uso y el cuadro de clasificación. No existe un único espacio dedicado a la transparencia en el que se agrupe toda esta información. Conclusiones. La propuesta TransPa_BA es válida para conocer si estos servicios están comprometidos con la publicidad activa, además de promover un aprendizaje colectivo que contribuya a la incorporación gradual de información que refuerce la transparencia activa de este servicio universitario o, si fuera el caso, eliminar elementos redundantes. Originalidad/Valor. Los indicadores y sus correspondientes atributos (presentación, forma, accesibilidad, reutilización, datación y actualización) ofrecen un marco para que los archivos universitarios puedan mejorar en transparencia y rendición de cuentas sobre sus actividades y principales resultados a sus grupos de interés.Objective. The article addresses the active disclosure transparency index obtained for 45 Spanish public university archives based on an analysis of their respective websites with TransPa_BA software. Design/Methodology/Approach. TransPa_BA, a tool inspired by Spain’s Metodología de Evaluación y Seguimiento de la Transparencia [transparency assessment and monitoring method, MESTA], features a total of 22 indicators that measure active public disclosure by archives in keeping with the provisions of the national Transparency Act. Results/Discussion. Although the findings reveal some good practices, on the whole these institutions were observed to furnish scant transparency-targeted information. The areas where they are strongest include the staff directory, regulations for use and the classification chart. None of the archives analysed groups all that information on a page specifically devoted to transparency, however. Conclusions. The TransPa-BA tool can be effectively used to determine the extent to which such university services are committed to active public disclosure. At the same time it encourages collective learning liable to contribute to the gradual disclosure of information that reinforces their transparency or eliminates unnecessary elements, as appropriate. Originality/value. The indicators and their associated parameters (visibility, form, accessibility, reusability, dating and currency) provide guidelines enabling university archives to heighten their transparency and comply more fully with the accountability owed to their primary stakeholders respecting their activities and performance.Esta publicación es parte de los resultados del proyecto de I+D+i / ayuda RTI2018-095187-B-I00, financiado por Ministerio de Ciencia, Innovación y Universidades, CIN/AEI/10.13039/501100011033/ y por la Unión Europea - FEDER "Una manera de hacer Europa"

MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity.

Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS pathology remains understudied. Here, we identified an enriched CD16+ CD56hi NK cell subset associated with higher cytotoxic function, as well as elevated proportions of inflammatory CD64+ conventional dendritic cell (cDC2) subtype that expresses increased levels of MICa/b, the ligand for the activating receptor NKG2D, in pSS individuals. Circulating cDC2 from pSS patients efficiently induced activation of cytotoxic NK cells ex vivo and were found in proximity to CD56+ NK cells in salivary glands (SG) from pSS patients. Interestingly, transcriptional activation of IFN signatures associated with the RIG-I/DDX60 pathway, IFN I receptor, and its target genes regulate the expression of NKG2D ligands on cDC2 from pSS patients. Finally, increased proportions of CD64hi RAE-1+ cDC2 and NKG2D+ CD11b+ CD27+ NK cells were present in vivo in the SG after poly I:C injection. Our study provides novel insight into the contribution and interplay of NK and cDC2 in pSS pathology and identifies new potential therapy targets.S

IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study

Background: Patients with coronavirus disaese 2019 (COVID-19) can develop a cytokine release syndrome that eventually leads to acute respiratory distress syndrome requiring invasive mechanical ventilation (IMV). Because IL-6 is a relevant cytokine in acute respiratory distress syndrome, the blockade of its receptor with tocilizumab (TCZ) could reduce mortality and/or morbidity in severe COVID-19. Objective: We sought to determine whether baseline IL-6 serum levels can predict the need for IMV and the response to TCZ. Methods: A retrospective observational study was performed in hospitalized patients diagnosed with COVID-19. Clinical information and laboratory findings, including IL-6 levels, were collected approximately 3 and 9 days after admission to be matched with preadministration and postadministration of TCZ. Multivariable logistic and linear regressions and survival analysis were performed depending on outcomes: need for IMV, evolution of arterial oxygen tension/fraction of inspired oxygen ratio, or mortality. Results: One hundred forty-six patients were studied, predominantly males (66%); median age was 63 years. Forty-four patients (30%) required IMV, and 58 patients (40%) received treatment with TCZ. IL-6 levels greater than 30 pg/mL was the best predictor for IMV (odds ratio, 7.1; P < .001). Early administration of TCZ was associated with improvement in oxygenation (arterial oxygen tension/fraction of inspired oxygen ratio) in patients with high IL-6 (P = .048). Patients with high IL-6 not treated with TCZ showed high mortality (hazard ratio, 4.6; P = .003), as well as those with low IL-6 treated with TCZ (hazard ratio, 3.6; P = .016). No relevant serious adverse events were observed in TCZ-treated patients. Conclusions: Baseline IL-6 greater than 30 pg/mL predicts IMV requirement in patients with COVID-19 and contributes to establish an adequate indication for TCZ administrationThis study was funded by Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and Instituto de Salud Carlos III (grant nos. RD16/0011/0012 and PI18/ 0371 to I.G.A., grant no. PI19/00549 to A.A., and grant no. SAF2017-82886-R to F.S.-M.) and co-funded by the European Regional Development Fund. The study was also funded by ‘‘La Caixa Banking Foundation’’ (grant no. HR17-00016 to F.S.-M.) and ‘‘Fondos Supera COVID19’’ by Banco de Santander and CRUE. None of these sponsors have had any role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publicatio

One hundred years of EEG for brain and behaviour research

On the centenary of the first human EEG recording, more than 500 experts reflect on the impact that this discovery has had on our understanding of the brain and behaviour. We document their priorities and call for collective action focusing on validity, democratization and responsibility to realize the potential of EEG in science and society over the next 100 years

Diferencias electroencefalográficas en niños con dos subtipos del trastorno por déficit de atención con hiperactividad Differences in the electroencephalogram of children from two subtypes of the attention deficit hyperactivity disorder

Los estudios electroencefalográficos en niños con Trastorno por déficit de atención con Hiperactividad (TDAH) reportan perfiles específicos en diferentes subtipos del trastorno. Este estudio investiga la presencia de alteraciones electroencefalográficas en un grupo de niños del subtipo hiperactivo/impulsivo y combinado. Se estudiaron 15 niños del subtipo hiperactivo/impulsivo y 15 del combinado del TDAH a los que se les realizó un electroencefalograma en vigilia. Los principales hallazgos al electroencefalograma fueron el incremento de la actividad lenta frontal y la presencia de descargas epileptiformes en ambos grupos. Se encontraron diferencias significativas entre los espectros de frecuencia de ambos grupos, por exceso en las bandas lentas y por defecto en las rápidas en el hiperactivo/impulsivo respecto al combinado. Estos resultados respaldan el modelo de un déficit de maduración del Sistema Nervioso Central como base del TDAH.<br>Electroencephalographic studies in children with Attention Deficit Hyperactivity Disorder (ADHD) report specific profiles in different subtypes. This study investigated the presence of Electroencephalogram abnormalities within a sample of children with the Hyperactive-Impulsive and combined subtypes of the disorder. Subjects consisted of 15 children of hyperactive-Impulsive and 15 children of combined subtypes. Electroencephalogram was recorded during an eyes closed resting condition. The principal findings were characterized by increased slow wave activity in frontal area and the visual analysis showed epileptiforms abnormalities in both groups. There was statistic difference in the spectrum of frequency in both subtypes characterized for more slow activity and less rapid activity in the hyperactive-Impulsive subtipe. These results support a model of ADHD resulting from a maturational lag in the Central Nervous System