Microvascular alterations in hypertension and vascular aging

Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and reduced regenerative capacity of the endothelium. Different phenotypes of hypertension have been described in younger and adult subjects with hypertension. In younger patients functional and structural alterations of resistance arteries occur as the earliest vascular alterations which have prognostic significance and may contribute to stiffness of large arteries through wave reflection. In individuals above age of 50 years as well as in subjects with long-lasting elevated blood pressure, vascular changes occur predominantly in conduit arteries which become stiffer. Activation of renin-angiotensin-aldosterone and endothelin systems plays a key role in endothelial dysfunction, vascular remodelling, and aging by inducing reactive oxygen species production, and promoting inflammation and cell growth

Can past gamma-ray bursts explain both INTEGRAL and ATIC/PAMELA/Fermi anomalies simultaneously?

Gamma-ray bursts (GRBs) have been invoked to explain both the 511 keV emission from the galactic bulge and the high-energy positron excess inferred from the ATIC, PAMELA, and Fermi data. While independent explanations can be responsible for these phenomena, we explore the possibility of their common GRB-related origin by modeling the GRB distribution and estimating the rates. For an expected Milky Way long GRB rate, neither of the two signals is generic; the local excess requires a 2% coincidence, while the signal from the galactic center requires a 20% coincidence with respect to the timing of the latest GRB. The simultaneous explanation requires a 0.4% coincidence. Considering the large number of statistical "trials" created by multiple searches for new physics, the coincidences of a few per cent cannot be dismissed as unlikely. Alternatively, both phenomena can be explained by GRBs if the galactic rate is higher than expected. We also show that a similar result is difficult to obtain assuming a simplified short GRB distribution.Comment: 4 pages; version accepted for publicatio

Optically-pumped saturable absorber for fast switching between continuous-wave and passively mode-locked regimes of a Nd:YVO4 laser

We report on the fast (~50 μs) remote-controlled switching between continuous-wave (cw), cw mode-locked (ML) and Q-switched ML modes of operation of a Nd:YVO4 laser using an optically-pumped saturable absorber (SA). Pulses as short as 40 ps with an average output power of 0.5 W are obtained in cw ML regime

Optical trapping with "on-demand" two-photon luminescence using Cr:LiSAF laser with optically addressed saturable Bragg reflector

We demonstrate a diode-pumped Cr:LiSAF laser with controllable and reliable fast switching between its continuous-wave and mode-locked states of operation using an optically-addressed semiconductor Bragg reflector, permitting dyed microspheres to be continuously trapped and monitored using a standard microscope imaging and on-demand two-photon-excited luminescence techniques

GaN directional couplers for integrated quantum photonics

Large cross-section GaN waveguides are proposed as a suitable architecture to achieve integrated quantum photonic circuits. Directional couplers with this geometry have been designed with aid of the beam propagation method and fabricated using inductively coupled plasma etching. Scanning electron microscopy inspection shows high quality facets for end coupling and a well defined gap between rib pairs in the coupling region. Optical characterization at 800 nm shows single-mode operation and coupling-length-dependent splitting ratios. Two photon interference of degenerate photon pairs has been observed in the directional coupler by measurement of the Hong-Ou-Mandel dip with 96% visibility.Comment: 4 pages, 5 figure

Evolution de la ressource en eau dans la vallée du Merguellil (Tunisie centrale)

International audienceLa plaine de Kairouan (Tunisie centrale) se trouve au débouché des trois grandes vallées du Zéroud, du Merguellil et du Nebhana. Dans ce contexte semi-aride (pluies moyennes entre 200 et 400 mm.an−1), l'intensification de l'irrigation au cours des dernières décennies a suscité une forte croissance de la demande en eau. En même temps, différents aménagements affectent l'ensemble du fonctionnement hydrologique : multiples ouvrages de conservation des eaux et des sols, petits et moyens, d'une part, grands barrages de protection contre les crues sur les trois oueds majeurs d'autre part. La distribution de l'eau B la surface du bassin-versant et dans le sous-sol a donc considérablement évolué et change encore. Dans la plaine du Merguellil, à l'aval du barrage el Haouareb, la nappe alluviale quaternaire est devenue la seule ressource en eau disponible. Elle est actuellement exploitée sans réel contrôle, ce qui conduit à une baisse sensible de son niveau (de 0,25 à 1 m par an). Elle n'est plus alimentée comme en régime naturel par les crues de l'oued, désormais entièrement bloquées par le barrage. Elle ne reçoit plus que les apports des nappes latérales et le flux souterrain passant sous le barrage. L'avenir du développement agricole régional dépend de manière évidente de la maîtrise de la ressource souterraine et donc de sa bonne connaissance. Malgré de multiples mesures de terrain et études entreprises depuis plusieurs décennies, il reste encore de nombreuses incertitudes qui rendent le bilan actuel de la nappe très incertain, à la fois sur les flux entrants et sortants. La surexploitation est nette et générale et aucune solution alternative simple n'apparaît. Le risque d'augmentation à long terme de la minéralisation existe mais ce problème est moins grave et moins immédiat que la baisse piézométrique

Strictly Toral Dynamics

This article deals with nonwandering (e.g. area-preserving) homeomorphisms of the torus $\mathbb{T}^2$ which are homotopic to the identity and strictly toral, in the sense that they exhibit dynamical properties that are not present in homeomorphisms of the annulus or the plane. This includes all homeomorphisms which have a rotation set with nonempty interior. We define two types of points: inessential and essential. The set of inessential points $ine(f)$ is shown to be a disjoint union of periodic topological disks ("elliptic islands"), while the set of essential points $ess(f)$ is an essential continuum, with typically rich dynamics (the "chaotic region"). This generalizes and improves a similar description by J\"ager. The key result is boundedness of these "elliptic islands", which allows, among other things, to obtain sharp (uniform) bounds of the diffusion rates. We also show that the dynamics in $ess(f)$ is as rich as in $\mathbb{T}^2$ from the rotational viewpoint, and we obtain results relating the existence of large invariant topological disks to the abundance of fixed points.Comment: Incorporates suggestions and corrections by the referees. To appear in Inv. Mat

Improving on whole-brain radiotherapy in patients with large brain metastases: a planning study to support the AROMA clinical trial

PURPOSE: To develop a novel dose-escalated volumetric modulated arc therapy (VMAT) strategy for patients with single or multiple large brain metastases which can deliver a higher dose to individual lesions for better local control (LC), and to compare dosimetry between whole brain radiotherapy (WBRT), hippocampal-sparing whole brain radiotherapy (HS-WBRT) and different VMAT-based focal radiotherapy approaches. METHODS AND MATERIALS: We identified 20 patients with one to ten brain metastases and at least one lesion larger than 15 cm3 who had received WBRT as part of routine care. For each patient, we designed and evaluated five radiotherapy treatment plans, including WBRT, HS-WBRT and three VMAT dosing models. A dose of 20 Gy in 5 fractions was prescribed to the whole brain or target volumes depending on the plan, with higher doses to smaller lesions and dose-escalated inner planning target volumes (DE-iPTV) in VMAT plans, respectively. Treatment plans were evaluated using the efficiency index, mean dose and D0.1cc to the target volumes and organs at risk. RESULTS: Compared with WBRT, VMAT plans achieved a significantly more efficient dose distribution in brain lesions, especially with our DE-iPTV model, while minimising the dose to the normal brain and other organs at risks (OARs) (p < 0.05). CONCLUSIONS: VMAT plans obtained higher doses to brain metastases and minimised doses to OARs. Dose-escalated VMAT for larger lesions allows higher radiotherapy doses to be delivered to larger lesions while maintaining safe doses to OARs

A doublet of cosmic-ray events with primary energies >10^20 eV

The Telescope Array Collaboration has observed a cosmic-ray event with estimated primary energy of 1.38*10^20 eV whose arrival direction coincides (see arxiv:1205.5984), given the angular resolution of 1.5 deg, with that of an event with estimated primary energy of 1.23*10^20 eV observed by the Pierre Auger Observatory. The total number of events with energies >10^20 eV published by both experiments is six. I estimate the statistical significance of the doublet, which is rather weak, and point out that the arrival directions of events in the doublet coincide with the Galactic X-ray source Aql X-1.Comment: 4 pages, 3 figures, submitted to JETP Letters; v.2: a misprint correcte