A grid-based infrastructure for distributed retrieval

In large-scale distributed retrieval, challenges of latency, heterogeneity, and dynamicity emphasise the importance of infrastructural support in reducing the development costs of state-of-the-art solutions. We present a service-based infrastructure for distributed retrieval which blends middleware facilities and a design framework to ‘lift’ the resource sharing approach and the computational services of a European Grid platform into the domain of e-Science applications. In this paper, we give an overview of the DILIGENT Search Framework and illustrate its exploitation in the field of Earth Science

Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets

Abstract Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry. We demonstrate that TCM have a gene expression and cytokine signaling signature that lies between that of naive and TEM or TEMRA cells, whereas TEM and TEMRA are closely related. Our data define the molecular basis for the different functional properties of central and effector memory subsets. We show that TEM and TEMRA cells strongly express genes with known importance in CD8 T cell effector function. In contrast, TCM are characterized by high basal and cytokine-induced STAT5 phosphorylation, reflecting their capacity for self-renewal. Altogether, our results distinguish TCM and TEM/TEMRA at the molecular level and are consistent with the concept that TCM represent memory stem cells.</jats:p

Exact C=1 Boundary Conformal Field Theories

We present a solution of the problem of a free massless scalar field on the half line interacting through a periodic potential on the boundary. For a critical value of the period, this system is a conformal field theory with a non-trivial and explicitly calculable S-matrix for scattering from the boundary. Unlike all other exactly solvable conformal field theories, it is non-rational ({\it i.e.} has infinitely many primary fields). It describes the critical behavior of a number of condensed matter systems, including dissipative quantum mechanics and of barriers in ``quantum wires''.Comment: harvmac, 10 pages, PUPT-1432/IASSNS-HEP-93/7

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo

Abstract The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells. We further show that resting T cells preferentially express inhibitory LEF1 and TCF7 (TCF-1) isoforms and that T cell activation changes the isoform balance in favor of stimulatory TCF7 (TCF-1) isoforms. Altogether, our study suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation.</jats:p

Boundary susceptibility in the spin-1/2 chain: Curie like behavior without magnetic impurities

We investigate the low-temperature thermodynamics of the spin-1/2 Heisenberg chain with open ends. On the basis of boundary conformal field theory arguments and numerical density matrix renormalization group calculations, it is established that in the isotropic case the impurity susceptibility exhibits a Curie-like divergent behavior as the temperature decreases, even in the absence of magnetic impurities. A similar singular temperature dependence is also found in the boundary contributions of the specific heat coefficient. In the anisotropic case, for $1/2<\Delta<1$, these boundary quantities still show singular temperature dependence obeying a power law with an anomalous dimension. Experimental consequences will be discussed.Comment: 5 pages, 1 figure, final versio

Loop Corrections in the Spectrum of 2D Hawking Radiation

We determine the one-loop and the two-loop back-reaction corrections in the spectrum of the Hawking radiation for the CGHS model of 2d dilaton gravity by evaluating the Bogoliubov coefficients for a massless scalar field propagating on the corresponding backgrounds. Since the back-reaction can induce a small shift in the position of the classical horizon, we find that a positive shift leads to a non-Planckian late-time spectrum, while a null or a negative shift leads to a Planckian late-time spectrum in the leading-order stationary-point approximation. In the one-loop case there are no corrections to the classical Hawking temperature, while in the two-loop case the temperature is three times greater than the classical value. We argue that these results are consistent with the behaviour of the Hawking flux obtained from the operator quantization only for the times which are not too late, in accordance with the limits of validity of the semiclassical approximation.Comment: 20 pages, latex, no figure

The Effects of Offering Hay, Pit-Stored Grass Silage or Big-Bale Silage to Pregnant Ewes on Ewe and Lamb Performance

Hay and pit silage have been used extensively for feeding sheep over the winter period, but in recent years, especially on smaller farms, big-bale silage has become increasingly popular. However, there is limited comparative information on the use of big-bale silage for sheep, especially in relation to the effects of chopping and growth stage at harvest. This study compared the performance of ewes offered hay, pit silage, or big-bale grass silage made from either chopped or unchopped grass and cut from the same field at the same time

Refining Fitness Functions for Search-Based Automated Program Repair: A Case Study with ARJA and ARJA-e

Several tools support code templates as a means to specify searches within a program’s source code. Despite their ubiquity, code templates can often prove difficult to specify, and may produce too many or too few match results. In this paper, we present a search-based approach to support developers in specifying templates. This approach uses a suite of mutation operators to recommend changes to a given template, such that it matches with a desired set of code snippets. We evaluate our approach on the problem of inferring a code template that matches all instances of a design pattern, given one instance as a starting template

Theory of nematic and polar active fluid surfaces

We derive a fully covariant theory of the hydrodynamics of nematic and polar active surfaces, subjected to internal and external forces and torques. We study the symmetries of polar and nematic surfaces and find that in addition to five different types of in-plane isotropic surfaces, polar and nematic surfaces can be classified into five polar, two pseudopolar, five nematic and two pseudonematic types of surfaces. We give examples of physical realisations of the different types of surfaces we have identified. We obtain expressions for the equilibrium tensions, moments, and external forces and torques acting on a passive polar or nematic surface. We calculate the entropy production rate using the framework of thermodynamics close to equilibrium and find constitutive equations for polar and nematic active surfaces with different symmetries. We study the instabilities of a confined flat planar-chiral polar active layer and of a confined deformable polar active surface with broken up-down symmetry

Gravitational Radiation from Travelling Waves on D-Strings

Boundary states that preserve supersymmetry are constructed for fractional D-strings with travelling waves on a ${\bf C}^3/ {{\bf Z}_2\times {\bf Z}_2}$ orbifold. The gravitational radiation emitted between two D-strings with antiparallel travelling waves is calculated.Comment: improvements and correction