Innovative housing policy tools: impact indicators in the NRRP Urban Regeneration Programmes

The topic of indicators as measurers of the effectiveness of urban and housing transformations strongly re-emerge because of the performance approach the funding of the National Recovery and Resilience Plan (NRRP) is based on. Within the NRRP specific programmes, the issue of performance measurability of interventions was managed with the application of different indicators and application methods. The research group had the opportunity to work on the construction of a system of indicators for a national urban regeneration programme, financed within the NRRP. This paper describes the research aimed at the definition of the indicators for evaluating the design proposals applied to the NRRP financed program called PINQuA (Innovative Programme for Housing Quality). The proposed system of indicators proved useful to promote an objective reading of the interventions and to encourage, in the design proposals application, the response to housing quality criteria aimed, among other issues, at improving the cultural condition of the contexts

Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease

The discovery that mammalian target of rapamycin (mTOR) inhibition increases lifespan in mice and restores/delays many aging phenotypes has led to the identification of a novel potential therapeutic target for the treatment of Alzheimer's disease (AD). Among mTOR inhibitors, everolimus, which has been developed to improve the pharmacokinetic characteristics of rapamycin, has been extensively profiled in preclinical and clinical studies as anticancer and immunosuppressive agent, but no information is available about its potential effects on neurodegenerative disorders. Using a reliable mouse model of AD (3 × Tg-AD mice), we explored whether short-term treatment with everolimus injected directly into the brain by osmotic pumps was able to modify AD-like pathology with low impact on peripheral organs. We first established in non-transgenic mice the stability of everolimus at 37 °C in comparison with rapamycin and, then, evaluated its pharmacokinetics and pharmacodynamics profiles through either a single peripheral (i.p.) or central (i.c.v.) route of administration. Finally, 6-month-old (symptomatic phase) 3 × Tg-AD mice were treated with continuous infusion of either vehicle or everolimus (0.167 μg/μl/day, i.c.v.) using the osmotic pumps. Four weeks after the beginning of infusion, we tested our hypothesis following an integrated approach, including behavioral (tests for cognitive and depressive-like alterations), biochemical and immunohistochemical analyses. Everolimus (i) showed higher stability than rapamycin at 37 °C, (ii) poorly crossed the blood-brain barrier after i.p. injection, (iii) was slowly metabolized in the brain due to a longer t 1/2 in the brain compared to blood, and (iv) was more effective in the CNS when administered centrally compared to a peripheral route. Moreover, the everolimus-induced mTOR inhibition reduced human APP/Aβ and human tau levels and improved cognitive function and depressive-like phenotype in the 3 × Tg-AD mice. The intrathecal infusion of everolimus may be effective to treat early stages of AD-pathology through a short and cyclic administration regimen, with short-term outcomes and a low impact on peripheral organs

Effect of parasympathetic stimulation on brain activity during appraisal of fearful expressions

Autonomic nervous system activity is an important component of human emotion. Mental processes influence bodily physiology, which in turn feeds back to influence thoughts and feelings. Afferent cardiovascular signals from arterial baroreceptors in the carotid sinuses are processed within the brain and contribute to this two-way communication with the body. These carotid baroreceptors can be stimulated non-invasively by externally applying focal negative pressure bilaterally to the neck. In an experiment combining functional neuroimaging (fMRI) with carotid stimulation in healthy participants, we tested the hypothesis that manipulating afferent cardiovascular signals alters the central processing of emotional information (fearful and neutral facial expressions). Carotid stimulation, compared with sham stimulation, broadly attenuated activity across cortical and brainstem regions. Modulation of emotional processing was apparent as a significant expression-by-stimulation interaction within left amygdala, where responses during appraisal of fearful faces were selectively reduced by carotid stimulation. Moreover, activity reductions within insula, amygdala, and hippocampus correlated with the degree of stimulation-evoked change in the explicit emotional ratings of fearful faces. Across participants, individual differences in autonomic state (heart rate variability, a proxy measure of autonomic balance toward parasympathetic activity) predicted the extent to which carotid stimulation influenced neural (amygdala) responses during appraisal and subjective rating of fearful faces. Together our results provide mechanistic insight into the visceral component of emotion by identifying the neural substrates mediating cardiovascular influences on the processing of fear signals, potentially implicating central baroreflex mechanisms for anxiolytic treatment targets

The impact of digital start-up founders’ higher education on reaching equity investment milestones

This paper builds on human capital theory to assess the importance of formal education among graduate entrepreneurs. Using a sample of 4.953 digital start-ups the paper evaluates the impact of start-up founding teams’ higher education on the probability of securing equity investment and subsequent exit for investors. The main findings are: (1), teams with a founder that has a technical education are less likely to remain self-financed and are more likely to secure equity investment and to exit, but the impact of technical education declines with higher level degrees, (2) teams with a founder that has doctoral level business education are less likely to remain self-financed and have a higher probability of securing equity investment, while undergraduate and postgraduate business education have no significant effect, and (3) teams with a founder that has an undergraduate general education (arts and humanities) are less likely to remain self-financed and are more likely to secure equity investment and exit while postgraduate and doctoral general education have no significant effect on securing equity investment and exit. The findings enhance our understanding of factors that influence digital start-ups achieving equity milestones by showing the heterogeneous influence of different types of higher education, and therefore human capital, on new ventures achieving equity milestones. The results suggest that researchers and policy-makers should extend their consideration of universities entrepreneurial activity to include the development of human capital

African Financial Development Dynamics: Big Time Convergence

In the first critical assessment of convergence in financial development dynamics in Africa, we find overwhelming support for integration. The empirical evidence is premised on 11 homogenous panels based on regions(Sub-Saharan and North Africa), income-levels(low, middle, lower-middle and upper-middle), legal-origins(English common-law and French civil-law) and religious dominations(Christianity and Islam). We examine convergence in financial intermediary dynamics of depth, efficiency, activity and size. Findings suggest that countries with small-sized financial intermediary depth, efficiency, activity and size are catching-up with countries with large-sized financial intermediary depth, efficiency, activity and size respectively. We also provide the speeds of convergence and time necessary to achieve a full(100%) convergence. As a policy implication African governments should not relent in structural and institutional reforms

La flessibilità come strategia per il riuso del patrimonio storico

The buildings reuse has been field of studies and researchs that moves from the realization of the inadequacy of current housing models and related aggregative models. The existiting constructions and architectural models are rendered obsolete by the changed needs framework and the different lifestyles that characterize contemporary society. The literature demonstrates the relevance of the theme: numerous and different buildings have been used for different functions in different periods; important research lines have existed that have deepened the themes of compatibility and flexibility of the project on the existing heritage. Functional reuse is essential for maintaining the cultural values of buildings: preserving historic buildings and giving them new functions according to their location and size, can help future generations to value and understand where they come from. The recovery action of a building organism is an unavoidable objective, as well as sustainable, obtainable through project and process tools, and, among these, especially through the flexible project tools that is born with the aim of satisfying the expected requirements from potential re-use actions of an architectural body. The contribution includes some reflections, the result of a recent research work of the Department of Architecture at Roma Tre University, useful for evaluating the limits and potentials of the flexible project tools on the existing heritage and on the historical architectural value. The notion of reuse has been investigated by extending this concept to that of “adaptive reuse”, which includes an adaptive approach to design action aimed at optimizing the use of resources. The factors that influence the decision-making process of re-use, such as the actors, the characteristics of the building, the conservation actions and functional changes, define the complexity of the process of re-use and/or of adaptive reuse, especially without an appropriate methodology where the different performances of buildings can be compared with the requisites required by new uses for evaluating their actual compatibility. The reading of the building organisms with reference to the technological system as a condition of greater or less flexibility of the environmental system and to the compatible performances obtainable with the minimum of physical transformation, are the instruments of this research to decline the theoretical reflection through some case studies. This reflection, in the complex of the theoretical-applicative lesson of the possible actions for re-use, shows how flexibility is a design strategy useful to reconcile the distance between the original functions and the new needs