Acute prostatitis as an uncommon presentation of brucellosis

The present report concerns a 46-year-old man who presented with acute prostatitis due to Brucella melitensis infection. He was first treated with doxycycline and ciprofloxacin, but after 3 months he was admitted again with the same diagnosis. The relapse was probably related to ciprofloxacin use, or the length of treatment not being sufficient. The patient was successfully treated with a combination of doxycycline and rifampin for 3 months. In conclusion, prostatitis due to Brucella, such as spondylitis, meningoencephalitis and endocarditis, should be treated for longer courses

TREATMENT OF TUBERCULOUS MENINGITIS IN TURKEY

A prospective study was performed on 72 cases of tuberculous meningitis studying various treatments. 37 patients were treated with a combination of isoniazid, rifampicin, pyrazinamide and streptomycin for 2 months, followed by a combination of isoniazid and rifampicin for 6 months. 35 patients were treated with various combinations of antituberculous drugs for 12-16 months. Disappearance of symptoms took (mean) 17 days. Mean duration of therapy for the hospitalized patients was 36 +/- 4 days. Seven (9.7%) patients died, 5 in the short-course therapy group and 2 in the long-course therapy group. Sequelae persisted in 18 (31%) cases, 8 of which cases were in the short-course therapy group and 10 in the long-course therapy group. No relapse was observed in either of the groups

Antimicrobial resistance of gram-negative isolates from intensive care units in Turkey: Comparison to previous three years (vol 12, pg 294, 2000)

WOS: 000166156600019Resistance rates to selected antibiotics of Gram-negative bacteria isolated from intensive care units (ICU) of 16 Turkish hospitals during 1998 were evaluated and compared to data from the previous 3 years. Antibiotic susceptibilities to imipenem, ceftazidime, ceftazidime-clavulanate, cefoperazone-sulbactam, ceftriaxone, cefepime, cefodizime, cefuroxime, piperacillin-tazobactam, ticarcillin-clavulanate, gentamicin, amikacin and ciprofloxacin were determined by Etest, A total of 1,404 isolates from 1,060 patients were collected, mainly from urinary and respiratory tracts. As in the previous 3 years, Pseudomonas spp, was the most frequently isolated Gram-negative species (29.7%), followed by Escherichia coli, Acinetobacter and Klebsiella spp, Imipenem was the most active in vitro agent (73.4% susceptible), followed by ciprofloxacin (60.6%), cefoperazone-sulbactam (58.7%), cefepime (56.7%), piperacillin-tazobactam (55.0%) and amikacin (54.7%), In 1996, a decline in susceptibility rates of all antibiotics was evident. With the exception of imipenem, resistance to which remained stable, rates somewhat increased in 1997. In 1998, susceptibility to imipenem and cefepime remained stable, amikacin resistance tended to increase and susceptibility rates to other antibacterials showed a favorable increase. These results may in part be due to the implementation of a surveillance program and increased understanding of the magnitude of the resistance problem

Antimicrobial resistance of Gram-negative isolates from intensive care units in Turkey: Comparison to previous three years

Resistance rates to selected antibiotics of Gram-negative bacteria isolated from intensive care units (ICU) of 16 Turkish hospitals during 1998 were evaluated and compared to data from the previous 3 years. Antibiotic susceptibilities to imipenem, ceftazidime, ceftazidime-clavulanate, cefoperazone-sulbactam, ceftriaxone, cefepime, cefodizime, cefuroxime, piperacillin-tazobactam, ticarcillin-clavulanate, gentamicin, amikacin and ciprofloxacin were determined by Etest, A total of 1,404 isolates from 1,060 patients were collected, mainly from urinary and respiratory tracts. As in the previous 3 years, Pseudomonas spp, was the most frequently isolated Gram-negative species (29.7%), followed by Escherichia coli, Acinetobacter and Klebsiella spp, Imipenem was the most active in vitro agent (73.4% susceptible), followed by ciprofloxacin (60.6%), cefoperazone-sulbactam (58.7%), cefepime (56.7%), piperacillin-tazobactam (55.0%) and amikacin (54.7%). In 1996, a decline in susceptibility rates of all antibiotics was evident. With the exception of imipenem, resistance to which remained stable, rates somewhat increased in 1997, In 1998, susceptibility to imipenem and cefepime remained stable, amikacin resistance tended to increase and susceptibility rates to other antibacterials showed a favorable increase. These results may in part be due to the implementation of a surveillance program and increased understanding of the magnitude of the resistance problem

Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report

Background: Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible individuals, notably patients with diabetes and leukemia. Rhinocerebral mucormycosis most commonly manifests itself in the setting of poorly controlled diabetes, especially with ketoacidosis

Is isepamicin a solution for aminoglycoside resistance?

Aminoglycosides are commonly used antibiotics especially in hospital-acquired infections. As a result of their widespread usage, resistance to these antibiotics is increasing. Isepamicin is a newly developed aminoglycoside and it is claimed that resistance to this antibiotic will develop in lower frequency in comparison with other aminoglycosides. This study was conducted to evaluate the resistance patterns of Gram-negative isolates to aminolycosides and to compare isepamicin with other aminoglycosides. All Gram-negative bacteriae isolated from blood and other cultures during the years 2000-2001 were tested against gentamicin, tobramycin, netilmicin, amikacin and isepamicin. The in-vitro susceptibility tests were performed by disk diffusion method. In total 3683 Gram-negative isolates were studied. According to our results, netilmicin (66.4%) was the most effective aminoglycoside. It was followed by isepamicin (64%), amikacin (63%), tobramicin (55.9%) and gentamicin (51.9%). Netilmicin was also the most effective aminoglycoside against Gram-negative bacteriae isolated from blood culture. Amikacin (62.6%) and isepamicin (62.5%) were equally effective against these isolates. In conclusion, netilmicin was the most effective aminoglycoside against Gram negative bacteriae. The resistance to isepamicin was significant

A study of serological markers of hepatitis B and C viruses in Istanbul, Turkey

Objective: This study was undertaken to investigate the prevalence of HBsAg, anti-HBs and anti-HCV positivity in Istanbul, Turkey. Subjects and Methods:The frequencies of HBsAg, anti-HBs and anti-HCV positivity were determined in 1,157 randomly selected patients attending the outpatient clinic of Istanbul University Hospital, Istanbul, Turkey, during the years 1998 and 2001. All patients underwent complete physical and various routine laboratory examinations. Results: Of the 1,157 patients, the prevalence of HBsAg, anti-HBs and anti-HCV was 6.6, 28.1 and 2.4%, respectively. It appeared that having dental and surgical procedures formed the risk factors for HBV infection. HBsAg positivity in the health care workers was not different from that of the other professions, but anti-HBs was significantly higher in this group. Conclusions: Our findings indicate that HBV infection occurs more frequently than HCV in Istanbul, and this poses an important health problem in the community. Copyright (C) 2003 S. Karger AG, Basel