71 research outputs found

    Secure Vehicular Communication Systems: Implementation, Performance, and Research Challenges

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    Vehicular Communication (VC) systems are on the verge of practical deployment. Nonetheless, their security and privacy protection is one of the problems that have been addressed only recently. In order to show the feasibility of secure VC, certain implementations are required. In [1] we discuss the design of a VC security system that has emerged as a result of the European SeVeCom project. In this second paper, we discuss various issues related to the implementation and deployment aspects of secure VC systems. Moreover, we provide an outlook on open security research issues that will arise as VC systems develop from today's simple prototypes to full-fledged systems

    Supportive care in patients with advanced non-small-cell lung cancer

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    Supportive care in patients with advanced non-small-cell lung cancer.

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    Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

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    We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts

    SPONGY STATE (STATUS SPONGIOSUS) AND INHIBITION OF NA,K-ATPASE - A PATHOGENETIC THEORY

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    Spongiform encephalopathies are characterized above all by spongiosis. This neuropathological characteristic is morphologically mimed by in vivo inhibition of cerebral brain Na,K-ATPase by means of subdural administration of ouabain. In this paper we underline the possibility that the ‘spongiotic state’ in other diseases might also be caused by the inhibition of this enzyme, thus hypothesizing that it is the enzyme itself that is targeted by the infective agent. The infective agent could, we believe, be shown to be linked to the enzyme if it were separated from the infected brain
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