50 research outputs found

    Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

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    Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and functionally distinct cell types such as white adipocytes and Leydig cells, that synthesize testosterone. Adipose tissue is able to control several functions of the testis through its products secreted in the bloodstream. On the other hand, circulating levels of testosterone and estradiol deeply affect adipocyte proliferation, differentiation, and fat mass distribution, hereby controlling critical metabolic functions, such as food intake, insulin sensitivity, vascular reactivity, and immunity. This paper highlights the existing clinical and experimental evidence linking androgens and adipose tissue and illustrates the consequences occurring when the balance between fat mass distribution and eugonadism is lost

    Reducing Implicit Racial Preferences: II Intervention Effectiveness Across Time

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    Implicit preferences are malleable, but does that change last? We tested 9 interventions (8 real and 1 sham) to reduce implicit racial preferences over time. In 2 studies with a total of 6,321 participants, all 9 interventions immediately reduced implicit preferences. However, none were effective after a delay of several hours to several days. We also found that these interventions did not change explicit racial preferences and were not reliably moderated by motivations to respond without prejudice. Short-term malleability in implicit preferences does not necessarily lead to long-term change, raising new questions about the flexibility and stability of implicit preferences. (PsycINFO Database Recor

    Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects

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    Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. However, vitamin D endocrine system regulates several genes (about 3 % of the human genome) involved in cell differentiation, cell-cycle control, and cell function and exerts noncalcemic/pleiotropic effects on extraskeletal target tissues, such as immune and cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue. Several studies have demonstrated the role of vitamin D supplementation in the prevention/treatment of various autoimmune diseases and improvement of glucose metabolism, muscle, and adipose tissue function. Hence, this review aims to elucidate the effects of vitamin D on extraskeletal target tissues and to investigate the potential therapeutic benefit of vitamin D supplementation among a broad group of pathological conditions, especially with regard to metabolic and autoimmune diseases. In addition, we focused on the best daily intakes and serum levels of vitamin D required for extraskeletal benefits which, even if still controversial, appear to be higher than those widely accepted for skeletal effects

    Implicit Bias Reflects the Personal and the Social

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    This issue’s target article by Payne, Vuletich, and Lundberg (PV&L) does exactly what one should, presenting an argument that is thought-provoking and that challenges current orthodoxy. It also addresses an issue that has increasingly confounded attitudes researchers in recent years. The construct of “implicit bias” was initially conceptualized as a latent construct that exists within persons, relatively resistant to situational influences. A plethora of theoretical models converge on the notion that implicit biases, including intergroup biases, are representations that are stored in memory (e.g., Devine,1989; Fazio, Jackson, Dunton, & Williams, 1995; Gawronski & Bodenhausen, 2006; Greenwald et al., 2002; Wilson, Lindsay, & Schooler, 2000). Although some perspectives emphasize the role of culture in contributing to implicit measures of bias, even these perspectives rely on the learning and storage of mental representations (Olson & Fazio, 2004)

    Implicit Bias Reflects the Personal and the Social

    No full text
    This issue’s target article by Payne, Vuletich, and Lundberg (PV&L) does exactly what one should, presenting an argument that is thought-provoking and that challenges current orthodoxy. It also addresses an issue that has increasingly confounded attitudes researchers in recent years. The construct of “implicit bias” was initially conceptualized as a latent construct that exists within persons, relatively resistant to situational influences. A plethora of theoretical models converge on the notion that implicit biases, including intergroup biases, are representations that are stored in memory (e.g., Devine,1989; Fazio, Jackson, Dunton, & Williams, 1995; Gawronski & Bodenhausen, 2006; Greenwald et al., 2002; Wilson, Lindsay, & Schooler, 2000). Although some perspectives emphasize the role of culture in contributing to implicit measures of bias, even these perspectives rely on the learning and storage of mental representations (Olson & Fazio, 2004)

    Branch retinal artery embolization due to calcific aortic valve stenosis.

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    Purpose. Branch retinal artery occlusion caused by calcific embolization secondary to calcific aortic valvulopathy. Methods. A 45-year-old woman came to our attention complaining a sudden painless loss of her peripheral superior visual field. Best visual acuity was 20/20. Fundus examination revealed the presence of a retinal arterial embolic occlusion of the inferior branch. Fundus retinography, visual field, and fluorescein angiography were performed and medical therapy was started. The echocardiography examination revealed a tricuspid and calcified aortic valve with moderate stenosis and regurgitation. Due to the heart pathology, the patient moved to the cardiosurgery department, where an aortic valve replacement was performed. Results. Four months after cardiac surgery, visual acuity of both eyes was stable (20/20). Fundus examination showed a complete reabsorption of the retinal edema and the resolution of retinal pallor. Fluorescein angiography confirmed the delay of the arterial filling. No retinal ischemia was observed. The visual field examination confirmed the deep scotoma previously registered. Conclusions. Retinal arterial embolization is a rare but potentially devastating complication of calcific aortic stenosis. Initial retinal presentation of calcific aortic stenosis is a rare condition. Keeping in mind that these emboli may be recurrent and potentially bilateral, a sudden onset of visual field defects, especially in young asymptomatic patients, needs immediate diagnosis and consideration of an urgent surgical correction. (Eur J Ophthalmol 2010; 20: 625-8
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