"It may be verifyit that thy wit is thin" : Interpreting older Scots flyting through hip hop aesthetics

The extinct tradition of Scottish flyting bears a striking resemblance to American Hip Hop battle rap, a modern day manifestation of poetic invective that developed in the late 1970s among African-American youths in New York City.2 Adam Bradley (2009) describes this poetic phenomenon as "a verbal cutting contest that prizes wit and wordplay above all else" (177). By comparing Older Scots flyting with Hip Hop battle rap we hope to recover something of the tone and purpose of the medieval tradition, namely, that the poets who engaged in these public invectives were actually amicable rivals competing for increased court status and wealth.3Not

Utilizing the Cognitive Orientation to Occupational Performance Approach For Improved Performance and Executive Functioning

The Outreach Program (TOP) in the Kent School District assists young adults in their transition from high school to adulthood. The research team and Dr. Abbott, an occupational therapist at TOP, sought to address whether better outcomes when teaching instrumental activities of daily living (IADLs) to adolescents with intellectual disabilities occur when addressing underlying performance skills and client factors through the Cognitive Orientation to Occupational Performance (CO-OP) approach or when addressing them through traditional occupational therapy practices. There is strong evidence to support CO-OP as an effective strategy to improve performance and moderate evidence indicating that it improves executive functioning and cognitive flexibility for a variety of diagnoses. We recommend CO-OP be integrated into traditional therapy practices and that additional research is conducted to explore group implementation and include more diagnoses. Student researchers developed and presented an inservice presentation on the use and implementation of CO-OP in the school setting. An opportunity to receive Competency Assessment Units for NBCOT certification renewal through participation in a study group was provided during the inservice presentation to occupational therapists in Kent School District. Outcomes of this presentation were monitored through a survey to gain an understanding of whether the occupational therapists present would consider implementing CO-OP in their everyday practice. The findings suggest that the majority of people who attended the inservice presentation were interested in seeking more information regarding CO-OP without participating in the NBCOT study group. Additional research in the form of a scoping review is recommended in order to investigate what approaches best support developing autonomy and independent problem-solving in adolescents with intellectual disabilities

Pillbox intervention fidelity in medication adherence research: A systematic review

Background Pillboxes are widely available, have evidence of effectiveness, but translating pillboxes in self-management interventions requires an understanding of intervention components. Purpose To review components of intervention design, interventionist training, delivery, receipt, enactment, and targeted behaviors in adherence studies. Methods Five multidisciplinary databases were searched to find reports of controlled trials testing pillboxes and medication adherence interventions in adults managing medications. Details of treatment fidelity, that is, design, training, delivery, receipt, and enactment, were abstracted. Findings A total of 38 articles reporting 40 studies were included. Treatment fidelity descriptions were often lacking, especially reporting receipt and enactment, important for both control and intervention groups. Clearly reported details are needed to avoid making assumptions when translating evidence. Conclusion These findings serve as a call to action to explicitly state intervention details. Lack of reported intervention detail is a barrier to translating which components of pillboxes work in influencing medication adherence behaviors and outcomes

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Relationship Between Theory of Mind, Emotion Recognition, and Social Synchrony in Adolescents With and Without Autism

Difficulty in social communication and interaction is a primary diagnostic feature of ASD. Research has found that adolescents with ASD display various impairments in social behavior such as theory of mind (ToM), emotion recognition, and social synchrony. However, not much is known about the relationships among these dimensions of social behavior. Adolescents with and without ASD participated in the study. ToM ability was measured by viewing social animations of geometric shapes, recognition of facial emotions was measured by viewing pictures of faces, and synchrony ability was measured with a spontaneously arising interpersonal movement task completed with a caregiver and an intentional interpersonal task. Attention and social responsiveness were measured using parent reports. We then examined the relationship between ToM, emotion recognition, clinical measures of attention and social responsiveness, and social synchronization that arises either spontaneously or intentionally. Results indicate that spontaneous synchrony was related to ToM and intentional synchrony was related to clinical measures of attention and social responsiveness. Facial emotion recognition was not related to either ToM or social synchrony. Our findings highlight the importance of biological motion perception and production and attention for more fully understanding the social behavior characteristic of ASD. The findings suggest that the processes underlying difficulties in spontaneous synchrony in ASD are different than the processes underlying difficulties in intentional synchronization

The structure of human 15-lipoxygenase-2 with a substrate mimic

Atherosclerosis is associated with chronic inflammation occurring over decades. The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in large atherosclerotic plaques, and its activity has been linked to the progression of macrophages to the lipid-laden foam cells present in atherosclerotic plaques.We report here the crystal structure of human 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain. The loop is flanked by two Ca2+-binding sites that confer Ca2+-dependent membrane binding. A comparison of the human 15-LOX-2 and 5-LOX structures reveals similarities at the active sites, as well striking differences that can be exploited for design of isoform-selective inhibitors. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc

Acute Outcomes for the Full US Cohort of the FLASH Mechanical Thrombectomy Registry in Pulmonary Embolism

Background Evidence supporting interventional pulmonary embolism (PE) treatment is needed. Aims We aimed to evaluate the acute safety and effectiveness of mechanical thrombectomy for intermediate- and high-risk PE in a large real-world population. Methods FLASH is a multicentre, prospective registry enrolling up to 1,000 US and European PE patients treated with mechanical thrombectomy using the FlowTriever System. The primary safety endpoint is a major adverse event composite including device-related death and major bleeding at 48 hours, and intraprocedural adverse events. Acute mortality and 48-hour outcomes are reported. Multivariate regression analysed characteristics associated with pulmonary artery pressure and dyspnoea improvement. Results Among 800 patients in the full US cohort, 76.7% had intermediate-high risk PE, 7.9% had high-risk PE, and 32.1% had thrombolytic contraindications. Major adverse events occurred in 1.8% of patients. All-cause mortality was 0.3% at 48-hour follow-up and 0.8% at 30-day follow-up, with no device-related deaths. Immediate haemodynamic improvements included a 7.6 mmHg mean drop in mean pulmonary artery pressure (-23.0%; p Conclusions Mechanical thrombectomy with the FlowTriever System demonstrates a favourable safety profile, improvements in haemodynamics and functional outcomes, and low 30-day mortality for intermediate- and high-risk PE