Children’s travel as pedestrians: an international survey of policy and practice

A survey of OECD member countries was carried out to provide high level data on a consistent basis to identify and account for current patterns of child road safety . This paper reports the findings relating to children, aged 0-14 years, as pedestrians. Key survey elements included analyses of fatality data, relationships between socio-economic, demographic factors and fatality rates, and a questionnaire based survey. League tables based on average child pedestrian fatality rates were constructed for each OECD member country participating in our questionnaire enabling identification of the top five countries with the lowest pedestrian fatality rate as Sweden, The Netherlands, Finland, Germany, and Denmark. Few countries had quantitative information about children’s travel and its absence means that assessments are difficult about children’s safety and the relative risks they face, especially as pedestrians. There are large variations in the amount of walking between countries and growing car use is becoming an issue in one third of OECD countries. The main findings from the questionnaire survey were that the majority of countries did not have information on high risk groups but of those that did, the cross cutting themes of socio-economic and ethnic minority groups, young children and urban areas were identified. Three characteristics distinguish top countries in the League table from those doing less well: a strong approach to the introduction of infrastructure measures for pedestrian safety, including low speed limits in residential areas; conducting road safety campaigns at least once a year; and having legislation which assumes driver responsibility in an accident involving a child pedestrian. Having compulsory road safety education for children aged 6-9 years was a characteristic shared by most countries, as was the promotion of child pedestrian education and training initiatives and the commissioning of research. However there is lower research activity in less well performing countries

Self-replication and evolution of DNA crystals

Is it possible to create a simple physical system that is capable of replicating itself? Can such a system evolve interesting behaviors, thus allowing it to adapt to a wide range of environments? This paper presents a design for such a replicator constructed exclusively from synthetic DNA. The basis for the replicator is crystal growth: information is stored in the spatial arrangement of monomers and copied from layer to layer by templating. Replication is achieved by fragmentation of crystals, which produces new crystals that carry the same information. Crystal replication avoids intrinsic problems associated with template-directed mechanisms for replication of one-dimensional polymers. A key innovation of our work is that by using programmable DNA tiles as the crystal monomers, we can design crystal growth processes that apply interesting selective pressures to the evolving sequences. While evolution requires that copying occur with high accuracy, we show how to adapt error-correction techniques from algorithmic self-assembly to lower the replication error rate as much as is required

Morphing Planar Graph Drawings Optimally

We provide an algorithm for computing a planar morph between any two planar straight-line drawings of any $n$-vertex plane graph in $O(n)$ morphing steps, thus improving upon the previously best known $O(n^2)$ upper bound. Further, we prove that our algorithm is optimal, that is, we show that there exist two planar straight-line drawings $\Gamma_s$ and $\Gamma_t$ of an $n$-vertex plane graph $G$ such that any planar morph between $\Gamma_s$ and $\Gamma_t$ requires $\Omega(n)$ morphing steps

Establishing comprehensive oral assessments for children with safeguarding concerns.

The dental profession is well placed to contribute important information in child protection cases but no previous research has been reported that assesses the volume or impact of this information. Comprehensive oral assessment clinics were introduced and established as an integral part of comprehensive medical assessments for children with welfare concerns in Greater Glasgow and Clyde. An assessment protocol and standardised paperwork for comprehensive oral assessments were developed to enhance information sharing and patient access to appropriate care. Two cases are presented and discussed to demonstrate the value of dental input

Acoustic Inspection of Coated Steel Bar in Reinforced Concrete Structure

Bridges with reinforcement corrosion problems are now under careful inspection in Taiwan. Costly maintenance programs are underway and raising serious safety concern. There are various engineering solutions to salt-induced corrosion. Among them epoxy-coated reinforcing bars, commonly referred to as rebar, are frequently used in marine environment and other areas due to its durability, reasonable cost, and convenience. However, coated rebar has lower bond strength and is less ductile than uncoated rebar. Thus it could result in larger crack width during pull-out tests [1,2]. The bond strength between coated steel bars and covered concrete results from the adhesion at the steel-concrete boundary, the factional force, and the interlocking force provided by the raised ribs at the steel bar surface. The interlocking force is much stronger than the other two, while the factional force occurs only if the adhesion vanishes after delamination or disbonding starts

The Pain Divide: a cross-sectional analysis of chronic pain prevalence, pain intensity and opioid utilisation in England

Objectives: Our central research question was, in England, are geographical inequalities in opioid use driven by health need (pain)? To answer this question, our study examined: (1) if there are regional inequalities in rates of chronic pain prevalence, pain intensity and opioid utilisation in England; (2) if opioid use and chronic pain are associated after adjusting for individual-level and area-level confounders. Design: Cross-sectional study design using data from the Health Survey for England 2011. Setting England. Primary and secondary outcome measures: Chronic pain prevalence, pain intensity and opioid utilisation. Participants: Participant data relating to chronic pain prevalence, pain intensity and opioid usage data were obtained at local authority level from the Health Survey for England 2011; in total, 5711 respondents were included in our analysis. Methods: Regional and local authority data were mapped, and a generalised linear model was then used to explore the relationships between the data. The model was adjusted to account for area-level and individual-level variables. Results: There were geographical variations in chronic pain prevalence, pain intensity and opioid utilisation across the English regions—with evidence of a ‘pain divide’ between the North and the South, whereby people in the North of England more likely to have ‘severely limiting’ or ‘moderately limiting’ chronic pain. The intensity of chronic pain was significantly and positively associated with the use of opioid analgesics. Conclusions: There are geographical differences in chronic pain prevalence, pain intensity and opioid utilisation across England—with evidence of a ‘pain divide’. Given the public health concerns associated with the long-term use of opioid analgesics—and their questionable activity in the management of chronic pain—more guidance is needed to support prescribers in the management of chronic pain, so the initiation of opioids can be avoided

Hair follicle dermal cells repopulate the mouse haematopoietic system

Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental properties. Recent evidence suggests that a number of adult cell populations have much broader stem cell capabilities than previously thought. To examine whether this applied to the hair follicle, and with a view to developing the follicle as a stem cell model system we investigated whether adult hair follicles were capable of demonstrating haematopoietic stem cell activity. To investigate haematopoietic activity in hair follicles we first used in vitro haematopoietic colony assays. This demonstrated that rodent hair follicle end bulbs as well as micro-dissected dermal papilla and dermal sheath cells actively produced cells of erythroid and myeloid lineages but that follicle epithelial cells did not. As a more stringent test, we then transplanted cultured dermal papilla or dermal sheath cells from transgenically marked donor mice into lethally irradiated recipient mice and observed multi-lineage haematopoietic reconstitution when assayed at intervals of up to one year. Colony assays from bone marrow of primary recipients revealed that over 70% of clonogenic precursors were derived from donor hair follicle cells. When bone marrow from primary mice was harvested and used to repopulate secondary myeloablated recipients, multi-lineage haematopoietic engraftment was observed. Our data show that dermal but not epidermal compartments of the adult hair follicle have much broader stem cell activities than previously described. Although the treatment for many forms of blood disorder, such as leukemia, often requires transplantation of haematopoietic stem cells (HSC), their availability can be rate limiting. Given its easy accessibility, our identification of the hair follicle as a source of extramedullary haematopoietic stem cell activity makes it an attractive potential source for blood stem cell therapeutics and highlights its value as a model system in adult stem cell biology

Safeguarding children in dentistry: 1. Child protection training, experience and practice of dental professionals with an interest in paediatric dentistry

* Few dental professionals with child protection training have experience of making referrals. * There is a wide gap in practice between recognising signs of child abuse and neglect and responding effectively. * This may indicate missed opportunities to save children from continuing abuse. * There is a need for improved child protection information, support and training for dental professionals. Abstract Following several highly publicised inquiries into the deaths of children from abuse and neglect, there has been much recent interest in the role and responsibility of all health professionals to protect children at risk of maltreatment. The findings of a postal questionnaire, sent in March 2005 to 789 dentists and dental care professionals with an interest in paediatric dentistry working in varied settings in the UK, are presented in a two-part report and discussed in the context of current multi-agency good practice in safeguarding and promoting the welfare of children. This first part explores reported child protection training, experience and practice. There was a significant gap between recognising signs of abuse and responding effectively: 67% of respondents had suspected abuse or neglect of a child patient at some time in their career but only 29% had ever made a child protection referral. The dental profession is alerted to the need to ensure necessary appropriate action to safeguard children is always taken when child abuse or neglect are suspected