2,342 research outputs found
Preliminary results of the Mariner IV radio occultation measurements of the upper atmosphere of Mars
Mariner IV radio occultation measurements of Mars upper atmospher
Preliminary results of the Mariner IV OCCULATION measurement of the atmosphere of Mars
Mariner IV radio occultation measurement of Mars atmospher
A characterization of those automata that structurally generate finite groups
Antonenko and Russyev independently have shown that any Mealy automaton with
no cycles with exit--that is, where every cycle in the underlying directed
graph is a sink component--generates a fi- nite (semi)group, regardless of the
choice of the production functions. Antonenko has proved that this constitutes
a characterization in the non-invertible case and asked for the invertible
case, which is proved in this paper
Dapagliflozin reduces albuminuria over 2 years in patients with type 2 diabetes mellitus and renal impairment
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Associated reading skills in children with a history of Specific Language Impairment (SLI)
A large cohort of 200 eleven-year-old children with Specific Language Impairment (SLI) were assessed on basic reading accuracy and on reading comprehension as well as language tasks. Reading skills were examined descriptively and in relation to early language and literacy factors. Using stepwise regression analyses in which age and nonverbal IQ were controlled for, it was found that a single word reading measure taken at 7 years was unsurprisingly a strong predictor of the two different types of reading ability. However, even with this measure included, a receptive syntax task (TROG) entered when reading accuracy score was the DV. Furthermore, a test of expressive syntax/narrative and a receptive syntax task completed at 7 years entered into the model for word reading accuracy. When early reading accuracy was excluded from the analyses, early phonological skills also entered as a predictor of both reading accuracy and comprehension at 11 years. The group of children with a history of SLI were then divided into those with no literacy difficulties at 11 and those with some persisting literacy impairment. Using stepwise logistic regression, and again controlling for IQ and age, 7 years receptive syntax score (but not tests of phonology, expressive vocabulary or expressive syntax/narrative) entered as a positive predictor of membership of the ‘no literacy problems’ group regardless of whether early reading accuracy was controlled for in step one. The findings are discussed in relation to the overlap of SLI and dyslexia and the long term sequelae of language impairment
Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain.
Reduction in albuminuria with dapagliflozin cannot be predicted by baseline clinical characteristics or changes in most other risk markers
The sodium glucose co-transporter-2 inhibitor dapagliflozin has been shown to decrease urinary albumin-to-creatinine ratio (UACR). This effect, however, varies among individual patients. In this study, we assessed the baseline characteristics and concurrent changes in other cardiovascular risk markers that might be associated with UACR response to dapagliflozin. A pooled analysis of 11 phase 3 randomized, controlled clinical trials was performed. UACR change from baseline after 24 weeks treatment with dapagliflozin 10 mg/d in 531 patients with type 2 diabetes and UACR ≥30 mg/g at baseline was determined. UACR response was defined as >30% reduction from baseline at 24 weeks, whereas UACR non-response was defined as ≤30% reduction at 24 weeks. A total of 288 (54%) patients were classified as responders and 243 (46%) as non-responders. At 24 weeks, the UACR-adjusted mean change from baseline was -71.2% and 25.9% in responders and non-responders, respectively. Baseline characteristics were similar between both groups. Changes in HbA1c and body weight were comparable across groups. Responders showed a numerically larger reduction in estimated glomerular filtration rate and systolic blood pressure versus non-responders. UACR reduction to dapagliflozin is an individual characteristic that cannot be predicted by baseline clinical features or changes in metabolic variables. Whether UACR response would improve long-term renal and cardiovascular outcomes remains to be determined
Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs
Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods: 14 anesthetized and mechanically ventilated pigs were randomly assigned to the Roc group (3.78 mg/kg rocuronium bromide followed by continuous infusion of 1 mg/kg/min, n = 7) or to the Sal group (administration of the corresponding volume of normal saline, n = 7). Subsequently, acute normovolemic anemia was induced by simultaneous exchange of whole blood for a 6% hydroxyethyl starch solution (130/0.4) until a sudden decrease of total body O-2 consumption (VO2) indicated a critical limitation of O-2 transport capacity. The Hb concentration quantified at this time point (Hb(crit)) was the primary end-point of the protocol. Secondary endpoints were parameters of hemodynamics, O-2 transport and tissue oxygenation. Results: Hb(crit) was significantly lower in the Roc group (2.4 +/- 0.5 vs. 3.2 +/- 0.7 g/dl) reflecting increased anemia tolerance. NMB with rocuronium bromide reduced skeletal muscular VO2 and total body O-2 extraction rate. As the cardiac index increased simultaneously, total body VO2 only decreased marginally in the Roc group (change of VO2 relative to baseline -1.7 +/- 0.8 vs. 3.2 +/- 1.9% in the Sal group, p < 0.05). Conclusion: Deep NMB with rocuronium bromide increases the tolerance of acute normovolemic anemia. The underlying mechanism most likely involves a reduction of skeletal muscular VO2. During acellular treatment of an acute blood loss, NMB might play an adjuvant role in situations where profound stages of normovolemic anemia have to be tolerated (e.g. bridging an unexpected blood loss until blood products become available for transfusion). Copyright (C) 2011 S. Karger AG, Base
Renormalization group approach to energy level statistics at the integer quantum Hall transition
We extend the real-space renormalization group (RG) approach to the study of
the energy level statistics at the integer quantum Hall (QH) transition.
Previously it was demonstrated that the RG approach reproduces the critical
distribution of the {\em power} transmission coefficients, i.e., two-terminal
conductances, , with very high accuracy. The RG flow of
at energies away from the transition yielded the value of the critical
exponent, , that agreed with most accurate large-size lattice simulations.
To obtain the information about the level statistics from the RG approach, we
analyze the evolution of the distribution of {\em phases} of the {\em
amplitude} transmission coefficient upon a step of the RG transformation. From
the fixed point of this transformation we extract the critical level spacing
distribution (LSD). This distribution is close, but distinctively different
from the earlier large-scale simulations. We find that away from the transition
the LSD crosses over towards the Poisson distribution. Studying the change of
the LSD around the QH transition, we check that it indeed obeys scaling
behavior. This enables us to use the alternative approach to extracting the
critical exponent, based on the LSD, and to find very close
to the value established in the literature. This provides additional evidence
for the surprising fact that a small RG unit, containing only five nodes,
accurately captures most of the correlations responsible for the
localization-delocalization transition.Comment: 10 pages, 11 figure
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