98 research outputs found
Treatment of atherosclerotic renovascular hypertension: review of observational studies and a meta-analysis of randomized clinical trials.
open9Atherosclerotic renal artery stenosis can cause ischaemic nephropathy and arterial hypertension. We herein review the observational and randomized clinical trials (RCTs) comparing medical and endovascular treatment for control of hypertension and renal function preservation. Using the Population Intervention Comparison Outcome (PICO) strategy, we identified the relevant studies and performed a novel meta-analysis of all RCTs to determine the efficacy and safety of endovascular treatment when compared with medical therapy. The following outcomes were examined: baseline follow-up difference in mean systolic and diastolic blood pressure (BP), serum creatinine, number of drugs at follow-up, incident events (heart failure, stroke, and worsening renal function), mortality, cumulative relative risk of heart failure, stroke, and worsening renal function. Seven studies comprising a total of 2155 patients (1741 available at follow-up) were considered, including the recently reported CORAL Study. Compared with baseline, diastolic BP fell more at follow-up in patients in the endovascular than in the medical treatment arm (standard difference in means -0.21, 95% confidence interval (CI): -0.342 to -0.078, P = 0.002) despite a greater reduction in the mean number of antihypertensive drugs (standard difference in means -0.201, 95% CI: -0.302 to -0.1, P < 0.001). At variance, follow-up changes (from baseline) of systolic BP, serum creatinine, and incident cardiovascular event rates did not differ between treatment arms. Thus, patients with atherosclerotic renal artery stenosis receiving endovascular treatment required less anti-antihypertensive drugs at follow-up than those medically treated. Notwithstanding this, they evidenced a better control of diastolic BP.openopenCaielli P;Frigo AC;Pengo MF;Rossitto G;Maiolino G;Seccia TM;Calò LA;Miotto D;Rossi GPCaielli, P; Frigo, ANNA CHIARA; Pengo, Mf; Rossitto, G; Maiolino, G; Seccia, TERESA MARIA; Calò, La; Miotto, Diego; Rossi, Gianpaol
A 3D velocity model for earthquake location in Campi Flegrei area: application to the 1982-84 uplift event
The uplift crisis of the 1982-1984 in the Campi Flegrei area underlined
the importance of seismic surveillance for this volcanic caldera. One of the
key elements for an effective seismic network is to make use of a reliable velocity
model for earthquake location.
In the present work we will discuss criteria for the construction and validation
of a new 3D P-wave velocity model for earthquake location in the Campi
Flegrei area built from the integration of two high-resolution 3D tomographic
images of the region.
The model is used for locating a group of earthquakes from the uplift event of
the 1982-1984
A microseismic study in a low seismicityarea: the 2001 site-response experimentin the CittĂ di Castello Basin (Italy)
A site response experiment was performed in the basin of CittĂ di Castello (a small town in Central Italy) in May 2001. This study is part of a project on the evaluation of seismic hazard in seismogenic areas funded by
the Gruppo Nazionale Difesa dai Terremoti (GNDT). The experiment consisted of a dense fixed transect configuration
with most of the stations recording in continuous mode, and several ambient noise measurements
both in single station and in array configuration spread over the investigated area. The dense transect was composed of 26 seismic stations in a crosswise configuration with a maximum inter-station distance of 250 m. The stations were deployed in the southern part of the basin, from the eastern bedrock outcrop to the western
edge, across the town. About 70 earthquakes were recorded during 10 days of deployment, generally low magnitude or regional events. We located 23 earthquakes and 17 of them were located using the waveform similarity approach at 4 stations outside the target area. These 4 stations were part of a dense temporary seismic network involved in a previous experiment of the same project, aimed at performing a high-resolution picture of the local seismicity. Delay analysis on the recorded waveforms allowed us to infer the basin geometry at depth and estimate the S-wave velocity of sediments. Moreover, we evaluated relative site response along the E-W transect by performing a standard spectral ratio. Amplification factors up to 9 are found inside the basin; at frequencies above 5 Hz stations closer to the edges show higher amplification, whereas stations located in the middle of the basin, where the alluvial sediments are thicker (CD11-CD14), show higher amplification below 5 Hz. We considered the average amplification in two frequency bands (1-5 Hz and 5-10 Hz), representative of the resonance frequency for 2-3 storey buildings and 1 storey houses,respectively. Our results suggest that the potential hazard for 2-3 storey buildings is higher in the center of the basin (amplification factor up to 6), and for 1 storey houses is higher at the edges (amplification factor up to 5)
A geology-based 3D velocity model of the Amatrice Basin (Central Italy)
In this paper we present a new methodological approach which integrates geological and geophysical data into a 3D modelling process to be mainly employed in seismic hazard assessment studies of earthquake-prone areas around the world, as well as in applications for land use and urban planning. As a case study, the reconstruction of a geology-based 3D velocity model of the uppermost hundreds of metres of the Amatrice high-seismic-hazard area is described.
The model was constructed using geological (e.g., maps, cross-sections and core-wells) and geophysical (e.g., down-hole, MASW, refraction, and seismic noise measurements) data, which were georeferenced and uploaded into 3D geological modelling software, where faults, stratigraphic boundaries, and geophysical attributes were digitised, checked, hierarchised, and modelled. The performed 3D geological model was parameterised with Vs and Vp velocities and, finally, the environmental noise (i.e., horizontal-to-vertical spectral ratio analysis, HVSR) recorded at some seismic stations was compared with the seismic responses modelled at some nearby control points.
In the study area, the proposed geology-based 3D velocity model represents both a new potential geophysical prediction tool for areas devoid of geophysical measurements (i.e. HVSR curves) and a potential input-model for future ground-motion and seismic-wave-propagation simulations aimed at a more precise local seismic response assessment and, consequently, at the development of more realistic seismic hazard scenarios.
The model here presented constitutes a first version of the 3D geological-geophysical model for the studied area, which will be improved with new data and more advanced algorithms available in the future
Investigations of the Oligocene-Miocene opening of the Ligurian Basin using amphibious refraction seismic data
The Ligurian Basin is located north-west of Corsica at the transition from the western Alpine orogen to the Apennine system. The Back-arc basin was generated by the southeast trench retreat of the Apennines-Calabrian-Maghrebides subduction zone. The opening took place from late Oligocene to Miocene. While the extension led to extreme continental thinning and un-roofing of mantle material little is known about the style of back-arc rifting.
To shed light on the present day crustal and lithospheric architecture of the Ligurian Basin, active seismic data have been recorded on short period ocean bottom seismometers in the framework of SPP2017 4D-MB, the German component of AlpArray. Two refraction seismic profiles were shot across and along the centre of the Ligurian Basin. P01 was shot in an E-W direction from the Gulf of Lion to Corsica. The profile extends onshore Corsica to image the necking zone of continental thinning. P02 is a transect along the basin in NE-SW direction extending a previous shot seismic profile reaching to the Italian cost near Genua. The majority of the ocean bottom seismometer data show sedimentary and crustal phases of good quality and weaker in amplitude mantle phases to offsets up to 70 km. The arrivals of seismic phases were picked and inverted in a travel time tomography.
The results for p01 show a crust-mantle boundary in the central basin at ~12 km depth below sea surface. The crust-mantle boundary deepens from ~12 km to ~18 km within 25 - 30 km towards Corsica. The results do not map an axial valley as expected for oceanic spreading. However, an extremely thinned continental crust indicates a long-lasting rifting process that possibly did not initiate oceanic spreading before the opening of the Ligurian Basin stopped. This is in good agreement with recent kinematic modelling performed in the second phase of the SPP2017 4D-MB. The modelling results of p01 indicate that continental crust can be stretched over several million years when the opening rate is low, i.e. <2 mm/year, and syn-rift sedimentation rate is high. Subduction initiation could occur in ultra-thinned continental crust as basin inversion has been observed at the northern Ligurian margin as a result of the African-European convergence. Additionally, the observations from the Ligurian Basin might be transferred to the evolution of the Piemont-Liguro Ocean. So far oceanic crust was assumed as initial conditions for the subduction of the Piemont-Liguro Ocean. An ultra-thin continental crust as initial condition would explain the observed thin subducted Piemont-Liguro plate which seemed to be thinner than 6-7 km oceanic crust. Further, a dry continental crust could explain why no back-arc volcanism was observed. The along-basin profile p02 shows a deepening crust-mantle boundary from 11 to 13 km. Based on the retrieved velocity model, gravity modelling and further results from surrounding studies we conclude that the continental crust is thinning from the northeast to the southwest which is related to the increase of extension away from the rotation pole of the anticlockwise rotation of the Corsica-Sardinia block. It remains unclear if at the southern end of the profile the mantle is overlain directly by sediments or by extremely thinned continental crust of up to 2.5 km thickness. The results however document, that seafloor spreading and the formation of mantle-derived oceanic crust was not initiated during the extension of the Ligurian Basin
Microzonazione sismica di livello 3 ad Amatrice: carte di MS3 - percorso metodologico e risultati
Automatic speech analysis to early detect functional cognitive decline in elderly population
This study aimed at evaluating whether people with a normal cognitive function can be discriminated from subjects with a mild impairment of cognitive function based on a set of acoustic features derived from spontaneous speech. Voice recordings from 90 Italian subjects (age >65 years; group 1: 47 subjects with MMSE>26; group 2: 43 subjects with 20≤ MMSE ≤26) were collected. Voice samples were processed using a MATLAB-based custom software to derive a broad set of known acoustic features. Linear mixed model analyses were performed to select the features able to significantly distinguish between groups. The selected features (% of unvoiced segments, duration of unvoiced segments, % of voice breaks, speech rate, and duration of syllables), alone or in addition to age and years of education, were used to build a learning-based classifier. The leave-one-out cross validation was used for testing and the classifier accuracy was computed. When the voice features were used alone, an overall classification accuracy of 0.73 was achieved. When age and years of education were additionally used, the overall accuracy increased up to 0.80. These performances were lower than the accuracy of 0.86 found in a recent study. However, in that study the classification was based on several tasks, including more cognitive demanding tasks. Our results are encouraging because acoustic features, derived for the first time only from an ecologic continuous speech task, were able to discriminate people with a normal cognitive function from people with a mild cognitive decline. This study poses the basis for the development of a mobile application performing automatic voice analysis on-the-fly during phone calls, which might potentially support the detection of early signs of functional cognitive decline
Microzonazione sismica di livello 3 ad Amatrice: indagini geofisiche per la caratterizzazione sismica di sito
Campi Flegrei active seismic experiments waveforms compilation
A new experiment called SERAPIS (SEismic Reflection/Refraction
Acquisition Project for Imaging complex volcanic Structures) has been planned
and carried out, based on off-shore seismic energization and data acquisition on
land and on sea-bottom. The experiment was performed in September, 2001
during which the vessel NADIR of IFREMER (equipped with 12, 16-liters airgun)
produced more than 5000 air gun shots recorded at a sea-bottom seismograph
array of 72 OBS and 62 stations installed on-land. Active seismic refraction
DSS (Deep Seismic Soundings) acquired during the surveys conducted in
1980 and 1985 were recovered jointly with seismic data acquired in the Campi
Flegrei area in the framework of the MareVes97 (an experiment devoted to the
definition of the structure of the Somma-Vesuvio complex) offshore survey.
The data set acquired during the SERAPIS experiment has been successfully
used to infer 3D images of the volcanic structures of Campi Flegrei and
Neapolitan bay. Active seismic waveforms and related P-picks (more than
90000 data) from the SERAPIS experiment are also available in the project data
server
- …