Multiple Cavitary Nodules Accompanied by Pulmonary Nocardiosis in a Patient with Systemic Lupus Erythematosus

Pulmonary nocardiosis is a chronic suppurative infection that may occur in immunosuppressed patients. It can be self-limited, or it can have an acute, subacute, or chronic course. Radiological diagnosis of pulmonary nocardiosis is difficult because of the very low prevalence of the disease even in immunocompromised patients and is also problematic because the radiographic findings are diverse with no characteristic findings. Multiple nodules and cavitations are more commonly described in acquired immune deficiency syndrome (AIDS) patients but are uncommon in non-AIDS patients. Also, the association of nocardia infection with systemic lupus erythematosus has been described occasionally. In this article, we report a rare case of pulmonary nocardiosis with multiple cavitary lesions and acute respiratory failure in a HIV-negative patient with systemic lupus erythematosus who was receiving corticosteroid treatment

Changes in antimicrobial resistance and outcomes of health care-associated infections

To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%

The Spectrum Of Diseases Causing Fever Of Unknown Origin In Turkey: A Multicenter Study

Objective: The purpose of this trial was to determine the spectrum of diseases with fever of unknown origin (FUO) in Turkey. Methods: A prospective multicenter study of 154 patients with FUO in twelve Turkish tertiarycare hospitals was conducted. Results: The mean age of the patients was 42 +/- 17 years (range 17-75). Fifty-three (34.4%) had infectious diseases (ID), 47 (30.5%) had non-infectious inflammatory diseases (NIID), 22 (14.3%) had malignant diseases (MD), and eight (5.2%) had miscellaneous diseases (Mi). In 24 (15.6%) of the cases, the reason for high fever could not be determined despite intensive efforts. The most common ID etiologies were tuberculosis (13.6%) and cytomegalovirus (CMV) infection (3.2%). Adult Still's disease was the most common NIID (13.6%) and hematological malignancy was the most common MD (7.8%). In patients with NIID, the mean duration of reaching a definite diagnosis (37 +/- 23 days) was significantly longer compared to the patients with ID (25 +/- 12 days) (p = 0.007). In patients with MD, the mean duration of fever (51 +/- 35 days) was longer compared to patients with ID (37 +/- 38 days) (p = 0.052). Conclusions: Although infection remains the most common cause of FUO, with the highest percentage for tuberculosis, non-infectious etiologies seem to have increased when compared with previous studies. (C) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.WoSScopu