A transiting M-dwarf showing beaming effect in the field of Ruprecht 147

We report the discovery and characterization of an eclipsing M5Vdwarf star, orbiting a slightly evolved F7V main sequence star. In contrast to previous claims in the literature, we confirm that the system does not belong to the galactic open cluster Ruprecht 147. We determine its fundamental parameters combining K2 time-series data with spectroscopic observations from the McDonald Observatory, FIES@NOT, and HIRES@KECK. The very precise photometric data from the K2 mission allows us to measure variations caused by the beaming effect (relativistic doppler boosting), ellipsoidal variation, reflection, and the secondary eclipse. We determined the radial velocity using spectroscopic observations and compare it to the radial velocity determined from the beaming effect observed in the photometric data. The M5V star has a radius of 0.200+0.007−0.008  R⊙ and a mass of 0.187+0.012−0.013  M⊙. The primary star has a radius of 1.518+0.038−0.049 R⊙ and a mass of 1.008+0.081−0.097 M⊙. The orbital period is 5.441995 ± 0.000007 d. The system is one of the few eclipsing systems with observed beaming effect and spectroscopic radial velocity measurements and it can be used as a test case for the modelling of the beaming effect. Current and forthcoming space missions such as TESS and PLATO might benefit from the analysis of the beaming effect to estimate the mass of transiting companions without the need for radial velocity follow up observations, provided that the systematic sources of noise affecting this method are well understood.Funding for the K2 mission is provided by the NASA Science Mission directorate. HJD acknowledges support by grant ESP2015-65712-C5-4-R of the Spanish Secretary of State for R&D&i (MINECO). ME and WDC were supported by NASA grant NNX16AE70G to The University of Texas at Austin

N-Acetylcysteine for the Management of Non-Acetaminophen Drug-Induced Liver Injury in Adults : A Systematic Review

Funding Information: The present study has been supported by grants of the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional–FEDER (contract numbers: PI19/00883, P18‐RT‐3364‐2020), from the Consejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía, Spain) (UMA18‐FEDERJA‐194, PI18‐RT‐3364) and by the Agencia Española del Medicamento. JS-C holds a “Juan Rodés” research contract from the National System of Health, ISCIII (JR21/00066). IA-A holds a Sara Borrell contract (CD20/00083). HN holds a postdoctoral contract from the Junta de Andalucia (POSTDOC_21_00780). CIBERehd and Plataforma ISCIII Ensayos Clínicos (PT20/000127) are funded by ISCIII. This article is based upon work from COST Action “CA17112 - Prospective European Drug-Induced Liver Injury Network” supported by COST (European Cooperation in Science and Technology) ( www.cost.eu ). All authors of this manuscript are members of COST Action CA17112. The funding sources had no involvement in the study design; in the collection, analysis, and interpretation of data; in the writing of the report or in the decision to submit the manuscript for publication. Funding Information: The present study has been supported by grants of the Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional–FEDER (contract numbers: PI19/00883, P18‐RT‐3364‐2020), from the Consejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía, Spain) (UMA18‐FEDERJA‐194, PI18‐RT‐3364) and by the Agencia Española del Medicamento. JS-C holds a “Juan Rodés” research contract from the National System of Health, ISCIII (JR21/00066). IA-A holds a Sara Borrell contract (CD20/00083). HN holds a postdoctoral contract from the Junta de Andalucia (POSTDOC_21_00780). CIBERehd and Plataforma ISCIII Ensayos Clínicos (PT20/000127) are funded by ISCIII. This article is based upon work from COST Action “CA17112 - Prospective European Drug-Induced Liver Injury Network” supported by COST (European Cooperation in Science and Technology) (www.cost.eu). All authors of this manuscript are members of COST Action CA17112. The funding sources had no involvement in the study design; in the collection, analysis, and interpretation of data; in the writing of the report or in the decision to submit the manuscript for publication. Publisher Copyright: Copyright © 2022 Sanabria-Cabrera, Tabbai, Niu, Alvarez-Alvarez, Licata, Björnsson, Andrade and Lucena.Introduction: Idiosyncratic drug-induced liver injury (DILI) is a rare adverse reaction to drugs and other xenobiotics. DILI has different grades of severity and may lead to acute liver failure (ALF), for which there is no effective therapy. N-acetylcysteine (NAC) has been occasionally tested for the treatment of non-acetaminophen drug-induced ALF. However, limited evidence for its efficacy and safety is currently available. Our aim was to elucidate the benefit and safety of NAC in DILI and evaluate its hepatoprotective effect. Methods: We conducted a systematic review to evaluate the management and prevention focused on NAC in idiosyncratic DILI. The main outcomes included mortality due to DILI, time to normalization of liver biochemistry, transplant-free survival, and adverse events. We included clinical trials and observational studies, either prospective or retrospective. Results: A total of 11 studies were included after literature screening. All studies had different methodologies, and some of them had important risk of bias that may lead to interpreting their findings with caution. The majority of the studies proved NAC efficacy in a cohort of patients with ALF due to different etiologies, where DILI represented a subgroup. NAC seemed to improve transplant-free survival; however, its benefit was inconclusive in terms of overall survival. With regard to safety, NAC showed an adequate safety profile. In prevention studies, NAC showed a possible hepatoprotective effect; however, this finding is limited by the lack of studies and presence of bias. Conclusion: NAC treatment seems to have some benefit in non-acetaminophen drug-induced liver failure patients with acceptable safety; however, due to the lack of evidence and limitations detected across studies, its benefit must be corroborated in clinical trials with adequate methodology.Peer reviewe

Three Small Planets Transiting a Hyades Star

We present the discovery of three small planets transiting K2-136 (LP 358 348, EPIC 247589423), a late K dwarf in the Hyades. The planets have orbital periods of $7.9757 \pm 0.0011$, $17.30681^{+0.00034}_{-0.00036}$, and $25.5715^{+0.0038}_{-0.0040}$ days, and radii of $1.05 \pm 0.16$, $3.14 \pm 0.36$, and $1.55^{+0.24}_{-0.21}$ $R_\oplus$, respectively. With an age of 600-800 Myr, these planets are some of the smallest and youngest transiting planets known. Due to the relatively bright (J=9.1) host star, the planets are compelling targets for future characterization via radial velocity mass measurements and transmission spectroscopy. As the first known star with multiple transiting planets in a cluster, the system should be helpful for testing theories of planet formation and migration.Comment: Accepted to The Astronomical Journa

Exoplanets around Low-mass Stars Unveiled by K2

We present the detection and follow-up observations of planetary candidates around low-mass stars observed by the K2 mission. Based on light-curve analysis, adaptive-optics imaging, and optical spectroscopy at low and high resolution (including radial velocity measurements), we validate 16 planets around 12 low-mass stars observed during K2 campaigns 5-10. Among the 16 planets, 12 are newly validated, with orbital periods ranging from 0.96-33 days. For one of the planets (K2-151b) we present ground-based transit photometry, allowing us to refine the ephemerides. Combining our K2 M-dwarf planets together with the validated or confirmed planets found previously, we investigate the dependence of planet radius $R_p$ on stellar insolation and metallicity [Fe/H]. We confirm that for periods $P\lesssim 2$ days, planets with a radius $R_p\gtrsim 2\,R_\oplus$ are less common than planets with a radius between 1-2$\,R_\oplus$. We also see a hint of the "radius valley" between 1.5 and 2$\,R_\oplus$ that has been seen for close-in planets around FGK stars. These features in the radius/period distribution could be attributed to photoevaporation of planetary envelopes by high-energy photons from the host star, as they have for FGK stars. For the M dwarfs, though, the features are not as well defined, and we cannot rule out other explanations such as atmospheric loss from internal planetary heat sources, or truncation of the protoplanetary disk. There also appears to be a relation between planet size and metallicity: those few planets larger than about 3 $R_\oplus$ are found around the most metal-rich M dwarfs.Comment: 29 pages, 21 figures, 6 tables, Accepted in Astronomical Journa

Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury

The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders may share damage pathways, we analysed the metagenomic profile of the gut microbiota in NAFLD, with or without significant liver fibrosis, and in DILI, and we identified the main associated bacterial metabolic pathways. In the NAFLD group, we found a decrease in Alistipes, Barnesiella, Eisenbergiella, Flavonifractor, Fusicatenibacter, Gemminger, Intestinimonas, Oscillibacter, Parasutterella, Saccharoferementans and Subdoligranulum abundances compared with those in both the DILI and control groups. Additionally, we detected an increase in Enterobacter, Klebsiella, Sarcina and Turicibacter abundances in NAFLD, with significant liver fibrosis, compared with those in NAFLD with no/mild liver fibrosis. The DILI group exhibited a lower microbial bacterial richness than the control group, and lower abundances of Acetobacteroides, Blautia, Caloramator, Coprococcus, Flavobacterium, Lachnospira, Natronincola, Oscillospira, Pseudobutyrivibrio, Shuttleworthia, Themicanus and Turicibacter compared with those in the NAFLD and control groups. We found seven bacterial metabolic pathways that were impaired only in DILI, most of which were associated with metabolic biosynthesis. In the NAFLD group, most of the differences in the bacterial metabolic pathways found in relation to those in the DILI and control groups were related to fatty acid and lipid biosynthesis. In conclusion, we identified a distinct bacterial profile with specific bacterial metabolic pathways for each type of liver disorder studied. These differences can provide further insight into the physiopathology and development of NAFLD and DILI.This work was supported in part by a grant from the Instituto de Salud Carlos III (Spain) (PI18/01804, PI19/00883, PI21/01248), from the Consejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía, Spain) (PI18–RT‐3364, UMA18-FEDERJA-194), and from the Consejería de Salud (Junta de Andalucía, Spain) (PI-0285–2016). This study has been co-funded by FEDER funds (“A way to make Europe”) (“Andalucía se mueve con Europa”). CRD is supported by a grant from the Consejería de Transformación Económica, Industria, Conocimiento y Universidades de Junta de Andalucía (Spain) (DOC_01610). FMR is supported by a grant from the ISCIII (Spain) (FI19/00189). AC is supported by a grant from the ISCIII (Spain) (IFI18/00047). EGF is supported by the Nicolas Monardes program from the Consejería de Salud de Andalucía (Spain) (C-0031–2016). Funding for open access charge: Universidad de Málaga / CBUA (Spain)

Evaluating the GeoSnap 13-μ\mum Cut-Off HgCdTe Detector for mid-IR ground-based astronomy

New mid-infrared HgCdTe (MCT) detector arrays developed in collaboration with Teledyne Imaging Sensors (TIS) have paved the way for improved 10-$\mu$m sensors for space- and ground-based observatories. Building on the successful development of longwave HAWAII-2RGs for space missions such as NEO Surveyor, we characterize the first 13-$\mu$m GeoSnap detector manufactured to overcome the challenges of high background rates inherent in ground-based mid-IR astronomy. This test device merges the longwave HgCdTe photosensitive material with Teledyne's 2048x2048 GeoSnap-18 (18-$\mu$m pixel) focal plane module, which is equipped with a capacitive transimpedance amplifier (CTIA) readout circuit paired with an onboard 14-bit analog-to-digital converter (ADC). The final assembly yields a mid-IR detector with high QE, fast readout (>85 Hz), large well depth (>1.2 million electrons), and linear readout. Longwave GeoSnap arrays would ideally be deployed on existing ground-based telescopes as well as the next generation of extremely large telescopes. While employing advanced adaptive optics (AO) along with state-of-the-art diffraction suppression techniques, instruments utilizing these detectors could attain background- and diffraction-limited imaging at inner working angles <10 $\lambda/D$, providing improved contrast-limited performance compared to JWST MIRI while operating at comparable wavelengths. We describe the performance characteristics of the 13-$\mu$m GeoSnap array operating between 38-45K, including quantum efficiency, well depth, linearity, gain, dark current, and frequency-dependent (1/f) noise profile.Comment: 17 pages, 17 figures. Accepted for publication in special addition of Astronomische Nachrichten / Astronomical Notes as a contribution to SDW202

K2-60b and K2-107b. A Sub-Jovian and a Jovian Planet from the K2 Mission

We report the characterization and independent detection of K2-60b, as well as the detection and characterization of K2-107b, two transiting hot gaseous planets from the K2 space mission. We confirm the planetary nature of the two systems and determine their fundamental parameters combining the K2 time-series data with FIES @ NOT and HARPS-N @ TNG spectroscopic observations. K2-60b has a radius of 0.683 +/- 0.037 R-Jup and a mass of 0.426 +/- 0.037 M-Jup and orbits a G4 V star with an orbital period of 3.00267 +/- 0.00006 days. K2-107b has a radius of 1.44 +/- 0.15 R-Jup and a mass of 0.84 +/- 0.08 M-Jup and orbits an F9 IV star every 3.31392 +/- 0.00002 days. K2-60b is among the few planets at the edge of the so-called desert of short-period sub-Jovian planets. K2107b is a highly inflated Jovian planet orbiting an evolved star about to leave the main sequence