39 research outputs found

    Human plague: An old scourge that needs new answers

    Get PDF
    Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague’s resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a “One Health” approach

    Multipurpose applications of the accelerator-based neutron source GENEPI2

    Get PDF
    International audienceGENEPI2 (GEnérateur de NEutrons Pulsé Intense) is anaccelerator-based neutron source operating at LPSC laboratory in Grenoble(France). The neutrons are produced at 2.5MeV or 14.2MeV trough fusion reactions.GENEPI2 specifications allow performing efficiently accelerated irradiationtests of integrated circuits. This facility can also be operated to test and calibrate differenttypes of detectors. This paper will describe the facility and its performances.Then, measurements of the neutron production will be presented as well as differenttypes of experiments and irradiations. Finally, we describe upgrades undertaken toincrease the neutron flux and optimize the facility for multiple applications

    Operation of the accelerator driving the VENUS-F core for the low power ADS experiments Guinevere and FREYA at SCK-CEN

    No full text
    International audienceGUINEVERE and FREYA are European projects devoted to experimental studies ofaccelerator-driven system feasibility. They are mainly dedicated to on-line reactivitymonitoring, subcriticality determination and operational procedures. An experimentalreactor of SCK•CEN (Belgium) modified into a fast lead core, VENUS-F, is coupled to aversatile accelerator-driven neutron source developed by CNRS/IN2P3 (France) driving thereactor in different modes. A deuteron beam is provided by an electrostatic acceleratorwith a time structure driven solely by the ion source. The deuteron ions are accelerated(220 keV) onto a tritiated target located at the centre of the reactor core, creating neutronsby T(d,n) 4 He reactions. This paper describes the design and commissioning of the facilityand reports on the operation of the accelerator coupled to the reactor
    corecore