Dificultades en el Aprendizaje : unificación de Criterios Diagnósticos III. Criterios de Intervención Pedagógica

Contenido: Intervención Psicopedagógica en Dificultades en el Aprendizaje -- Intervención Psicopedagógica en Problemas Escolares -- Intervención Psicopedagógica en Bajo Rendimiento Escolar -- Intervención Psicopedagógica en Dificultades Específicas en el Aprendizaje -- Intervención Psicopedagógica en el Trastorno por Déficit de Atención con Hiperactividad -- Intervención Psicopedagógica en la Discapacidad Intelectual Límite. Anexos: Protocolo de Procedimiento/Inicio -- Protocolo de Evaluación -- Protocolo de Intervención -- Intervención en el caso nº 1. Problemas Escolares -- Intervención en el caso nº 2. Bajo Rendimiento Escolar -- Intervención en caso nº 3. Dificultades Específicas en el Aprendizaje -- Intervención en caso nº 4. Dificultades Específicas en el Aprendizaje -- Intervención en caso nº 5. Dificultades Específicas en el Aprendizaje -- Intervención en caso nº 6. Trastorno por Déficit de Atención con Hiperactividad -- Intervención en caso nº 7. Trastorno por Déficit de Atención con Hiperactividad -- Intervención en caso nº 8. Discapacidad Intelectual Límite -- Indice de Fichas por Áreas de Intervención -- Índice de Fichas por Dificultades en el Aprendizaje -- Protocolo de Adaptación Curricular -- Programas de Intervención Cognitivo-Conductuales para Profesores de niños con TDAH -- Recomendaciones para la modificación del ambiente de aula

Desarrollo de herramientas críticas e instrumentales y diseño de recursos educativos en abierto en torno al cómic

El cómic funciona como hilo conductor temático del proyecto, empleando las nuevas tecnologías y la teoría crítica de manera instrumental. cuenta con una triple vertiente: formación de estudiantes, formación de docentes y futuros docentes, y transferencia de resultados. Esta triple vertiente se desarrolla a través de tres ejes: (1) Club de lectura de cómic autogestionado por estudiantes, bajo el título «Narrativas éticas para repensar el mundo»; (2) Talleres instrumentales, teoría crítica y empleabilidad para estudiantes del club y el resto de la comunidad universitaria y un encuentro con una autora; (3) Realización de contenidos en abierto —podcasts,— con los resultados del aprendizaje en los ejes (1) y (2)

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

<i>Lkb1</i> Loss Promotes Tumor Progression of BRAF^V600E-Induced Lung Adenomas

<div><p>Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF^V600E) are found in 3% of human non-small cell lung cancers. Contrary to KRAS mutant tumors, BRAF^V600E-induced tumors are benign adenomas that fail to progess. Interestingly, loss of tumor supressor LKB1 coexists with KRAS oncogenic mutations and synergizes in tumor formation and progression, however, its cooperation with BRAF^V600E oncogene is unknown. Our results describe a lung cell population in neonates mice where expression of BRAF^V600E leads to lung adenoma development. Importantly, expression of BRAF^V600E concomitant with the loss of only a single-copy of Lkb1, overcomes senencence–like features of BRAF^V600E-mutant adenomas leading malignization to carcinomas. These results posit LKB1 haploinsufficiency as a risk factor for tumor progression of BRAF^V600E mutated lung adenomas in human cancer patients.</p></div

Dificultad en el aprendizaje : unificación de criterios diagnósticos : criterios de intervención pedagógica

Anexos en las páginas 107-143Colección de libros que constituye una serie de materiales para la práctica orientadora dirigidos al profesorado y a los orientadores y orientadoras que intervienen con el alumnado con necesidad específica de apoyo educativo. La colección trata diferentes aspectos relacionados con la atención educativa del alumnado que presenta problemas escolares, bajo rendimiento, dificultades específicas de aprendizaje, trastornos por déficit de atención con hiperactividad o discapacidad intelectual límite. En este volumen se define la intervención psicopedagógica en la dificultades en el aprendizaje, sus características y actuaciones generales, con elementos básicos de intervención, se ofrecen orientaciones al profesorado y a la familia y se aportan ejemplos de intervención en casos concretos.AndalucíaInstituto Psicopedagógico Dulce Nombre de María (Málaga); Calle Manuel de Palacio, 17; 29017 Málaga; +34902290499; [email protected]

Percentage of mice developing adenomas and adenocarcinomas.

<p>Hematoxylin and eosin staining of histological sections showing lung hyperplasia in Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i>; <i>Lkb1</i>^flox/+ (<b>A</b>, <b>B</b>) and CMV-<i>Cre</i>^T/+; <i>Kras</i>^+/LSLG12Vgeo mice (<b>J</b>, <b>K</b>). Higher magnification is showed in (<b>B</b>, <b>K</b>). Papillary adenomas developed in Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i>; <i>Lkb1</i>^flox/+ (<b>C</b>, <b>D</b>) and mixed papillary and solid adenomas developed in CMV-<i>Cre</i>^T/+; <i>K-ras</i>^+/LSLG12Vgeo (<b>L</b>, <b>M</b>). Note <b>C</b> and <b>L</b> tumors in higher magnification (<b>D</b>, <b>M</b>). Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i>; <i>Lkb1</i>^flox/+ adenocarcinoma (<b>E</b>) showing papillary (<b>F</b>) and solid (<b>G</b>) regions. Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i>; <i>Lkb1</i>^flox/+ adenocarcinoma showing intra bronchiolar tumor growth (*) (<b>H</b>). Higher magnification showing different cells populations in <b>H.</b> Atypical cells with nuclear hyperchromasia, and contour irregularities (*), cells showed enlarged nuclei displaying prominent nucleoli (**) and cells with hyperchromatic fusiform nuclei (arrows). CMV-<i>Cre</i>^T/+; <i>Kras</i>^+/LSLG12Vgeo adenomas and adenocarcinomas (<b>N</b>). Detail of solid (<b>O</b>) and mucinous (<b>P</b>) tumors. Dashed-lined squares indicate magnified areas. Bars 800 µm (<b>A</b>, <b>C</b>, <b>D</b>, <b>J</b>, <b>L</b> and <b>N</b>), 500 µm (<b>E</b>), 200 µm (<b>K</b>, <b>M</b>, <b>O</b> and <b>P</b>) and 100 µm (<b>B</b>, <b>D</b>, <b>F</b>, <b>G</b> and <b>I</b>).</p

Percentage of mice developing lung adenomas (L. adenomas) or lung adenocarcinomas (L. carcinomas) according to their genotype and treatment (4OHTx).

<p>Percentage of mice developing lung adenomas (L. adenomas) or lung adenocarcinomas (L. carcinomas) according to their genotype and treatment (4OHTx).</p

Neonatal activation of BRAF^V600E through the expression of Tyr::<i>Cre</i>^ERT2 upon 4OHTx treatment drives aberrant proliferation of lung cells.

<p>(<b>A</b>) Schematic representation of mouse treatment and expressed proteins. (<b>B</b>) Representative images of Cre-recombinase staining in 4-days-old wild type (WT, n = 3) and Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i> (n = 3) mice lungs treated with 4OHTx. Bars 80 µm. (<b>C</b>) Anti-p-ERK1/2 staining of untreated (−4OHTx) and treated (+4OHTx) 4-days-old Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i> mice lungs. (<b>D</b>) Schematic representation of the genetic strategy to identify tyrosinase-promoter driven Cre-recombinase lung expressing cells. Representative images of EYFP, SP-C and CC10 expressing cells in Tyr::<i>Cre</i>^ERT2;ROSA-lsl-<i>EYFP</i> mice 3 days after 4OHTx treatment (n = 3 mice) are shown. Bars 80 µm. (<b>E</b>) Ki67 staining of histologically normal lungs in 8-days-old mice showed increased proliferation index in 4OHTx treated Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i> mice compared to untreated. Bars 500 µm. Quantification of samples is shown below. 20X fields (n = 8 and n = 11 from 3 different untreated and 4OHTx treated mice respectively) were quantified. <i>p</i>-value was calculated performing Mann-Whitney’s test.</p

Immunostaining of histological sections of Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i> and CMV-<i>Cre</i>^T/+; <i>Kras</i>^+/LSLG12Vgeo adenomas (<i>Kras</i>^+/LSLG12Vgeo 6 months) and Tyr::<i>Cre</i>^ERT2; <i>Braf^CA/+</i>; <i>Lkb1</i>^flox/+ and CMV-<i>Cre</i>^T/+; <i>Kras</i>^+/LSLG12Vgeo adenocarcinomas (<i>Kras</i>^+/LSLG12Vgeo 11 months) with CC10, SP-C, E-Cadherin, Ki67, p53 and LKB1 antibodies.

<p>(*) indicates airways. Bars 500 µm and 80 µm for magnifications.</p