53 research outputs found
INTRABEAM: precision hypo-fractionated radiotherapy with a systemic immune response
Purpose or Objective: To evaluate the changes in immune-cell phenotype in peripheral blood following intraoperative radiotherapy (IORT) in breast cancer patients
Disease severity in familial cases of IBD
Background: Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence.
Aim: To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases.
Methods: 5783 patients (48.3%) had ulcerative colitis (UC) and 6200 (51.7%) Crohn's disease (CD). Cases with one or more 1st, 2nd or 3rd degree relatives affected by UC/CD were defined as familial case.
Results: In UC and CD, familial cases compared with sporadic cases had an earlier disease onset (UC: 33 years [IQR 25–44] vs 37 years [IQR 27–49]; p b 0.0001); (CD: 27 years [IQR 21–35] vs 29 years [IQR 22–40]; p b 0.0001), higher prevalence of extraintestinal immune-related manifestations (EIMs) (UC: 17.2% vs 14%; p = 0.04); (CD: 30.1% vs 23.6%; p b 0.0001). Familial CD had higher percentage of ileocolic location (42.7% vs 51.8%; p = 0.0001), penetrating behavior (21% vs 17.6%; p = 0.01) and perianal disease (32% vs 27.1%; p = 0.003). Differences are not influenced by degree of consanguinity.
Conclusion: When a sufficiently powered cohort is evaluated, familial aggregation in IBD is associated to an earlier disease onset, more EIMs and more severe phenotype in CD. This feature should be taken into account at establishing predictors of disease course
Coexistence of one- and two-dimensional supramolecular assemblies of terephthalic acid on Pd(111) due to self-limiting deprotonation
The ReactorSTM: Atomically resolved scanning tunneling microscopy under high-pressure, high-temperature catalytic reaction conditions
Quantum Matter and Optic
Combining biomarker and bulk compositional gradient analysis to assess reservoir connectivity
Author Posting. © The Author(s), 2010. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Organic Geochemistry 41 (2010): 812-821, doi:10.1016/j.orggeochem.2010.05.003.Hydraulic connectivity of petroleum reservoirs represents one of the biggest uncertainties for
both oil production and petroleum system studies. Here, a geochemical analysis involving bulk and
detailed measures of crude oil composition is shown to constrain connectivity more tightly than is
possible with conventional methods. Three crude oils collected from different depths in a single well
exhibit large gradients in viscosity, density, and asphaltene content. Crude oil samples are collected
with a wireline sampling tool providing samples from well‐defined locations and relatively free of
contamination by drilling fluids; the known provenance of these samples minimizes uncertainties in the
subsequent analysis. The detailed chemical composition of almost the entire crude oil is determined by
use of comprehensive two‐dimensional gas chromatography (GC×GC) to interrogate the nonpolar
fraction and negative ion electrospray ionization Fourier transform ion cyclotron resonance mass
spectrometry (ESI FT‐ICR MS) to interrogate the polar fraction. The simultaneous presence of 25‐
norhopanes and mildly altered normal and isoprenoid alkanes is detected, suggesting that the reservoir
has experienced multiple charges and contains a mixture of oils biodegraded to different extents. The
gradient in asphaltene concentration is explained by an equilibrium model considering only gravitational
segregation of asphaltene nanoaggregates; this grading can be responsible for the observed variation in
viscosity. Combining these analyses yields a consistent picture of a connected reservoir in which the
observed viscosity variation originates from gravitational segregation of asphaltene nanoaggregates in a
crude oil with high asphaltene concentration resulting from multiple charges, including one charge that
suffered severe biodegradation. Observation of these gradients having appropriate magnitudes
suggests good reservoir connectivity with greater confidence than is possible with traditional techniques
alone.The mass spectrometry work was
supported by the NSF Division of Materials Research through DMR‐06‐54118, and the State of Florida
Asymmetric Response toward Molecular Fluorination in Binary Copper–Phthalocyanine/Pentacene Assemblies
Strain-relief pattern as guide for the formation of surface-supported bimolecular nanoribbons
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