5,539 research outputs found
The Projected Rotational Velocity Distribution of a Sample of OB stars from a Calibration based on Synthetic He I lines
We derive projected rotational velocities (vsini) for a sample of 156
Galactic OB star members of 35 clusters, HII regions, and associations. The HeI
lines at 4026, 4388, and 4471A were analyzed in order to define
a calibration of the synthetic HeI full-widths at half maximum versus stellar
vsini. A grid of synthetic spectra of HeI line profiles was calculated in
non-LTE using an extensive helium model atom and updated atomic data. The
vsini's for all stars were derived using the He I FWHM calibrations but also,
for those target stars with relatively sharp lines, vsini values were obtained
from best fit synthetic spectra of up to 40 lines of CII, NII, OII, AlIII,
MgII, SiIII, and SIII. This calibration is a useful and efficient tool for
estimating the projected rotational velocities of O9-B5 main-sequence stars.
The distribution of vsini for an unbiased sample of early B stars in the
unbound association Cep OB2 is consistent with the distribution reported
elsewhere for other unbound associations.Comment: Accepted for publication in The Astronomical Journa
The HARPS search for southern extra-solar planets XXXV. The interesting case of HD41248: stellar activity, no planets?
The search for planets orbiting metal-poor stars is of uttermost importance
for our understanding of the planet formation models. However, no dedicated
searches have been conducted so far for very low mass planets orbiting such
objects. Only a few cases of low mass planets orbiting metal-poor stars are
thus known. Amongst these, HD41248 is a metal-poor, solar-type star on which a
resonant pair of super-Earth like planets has In the present paper we present a
new planet search program that is using the HARPS spectrograph to search for
Neptunes and Super-Earths orbiting a sample of metal-poor FGK dwarfs. We then
present a detailed analysis of an additional 162 radial velocity measurements
of HD41248, obtained within this program, with the goal of confirming the
existence of the proposed planetary system. We analyzed the precise radial
velocities, obtained with the HARPS spectrograph, together with several stellar
activity diagnostics and line profile indicators. A careful analysis shows no
evidence for the planetary system previously announced. One of the signals,
with a period of about 25 days, is shown to be related to the rotational period
of the star, and is clearly seen in some of the activity proxies. The remaining
signal (P~18 days) could not be convincingly retrieved in the new data set. We
discuss possible causes for the complex (evolving) signals observed in the data
of HD41248, proposing that they may be explained by the appearance and
disappearance of active regions on the surface of a star with strong
differential rotation, or by a combination of the sparse data sampling and
active region evolution.Comment: Accepted for publication in A&
Kalb-Ramond excitations in a thick-brane scenario with dilaton
We compute the full spectrum and eigenstates of the Kalb-Ramond field in a
warped non-compact Randall-Sundrum -type five-dimensional spacetime in which
the ordinary four-dimensional braneworld is represented by a sine-Gordon
soliton. This 3-brane solution is fully consistent with both the warped
gravitational field and bulk dilaton configurations. In such a background we
embed a bulk antisymmetric tensor field and obtain, after reduction, an
infinite tower of normalizable Kaluza-Klein massive components along with a
zero-mode. The low lying mass eigenstates of the Kalb-Ramond field may be
related to the axion pseudoscalar. This yields phenomenological implications on
the space of parameters, particularly on the dilaton coupling constant. Both
analytical and numerical results are given.Comment: 10 pages, 13 figures, and 2 tables. Final version to appear in The
European Physical Journal
Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation
International audienceThe Dark Energy Camera has captured a large set of images as part of Science Verification (SV) for the Dark Energy Survey (DES). The SV footprint covers a large portion of the outer Large Magellanic Cloud (LMC), providing photometry 1.5 mag fainter than the main sequence turn-off of the oldest LMC stellar population. We derive geometrical and structural parameters for various stellar populations in the LMC disc. For the distribution of all LMC stars, we find an inclination of i = -38.14° ± 0.08° (near side in the north) and a position angle for the line of nodes of θ0 = 129.51° ± 0.17°. We find that stars younger than ∼4 Gyr are more centrally concentrated than older stars. Fitting a projected exponential disc shows that the scale radius of the old populations is R>4 Gyr = 1.41 ± 0.01 kpc, while the younger population has R = 0.72 ± 0.01 kpc. However, the spatial distribution of the younger population deviates significantly from the projected exponential disc model. The distribution of old stars suggests a large truncation radius of Rt = 13.5 ± 0.8 kpc. If this truncation is dominated by the tidal field of the Galaxy, we find that the LMC is {∼eq } 24^{+9}_{-6} times less massive than the encircled Galactic mass. By measuring the Red Clump peak magnitude and comparing with the best-fitting LMC disc model, we find that the LMC disc is warped and thicker in the outer regions north of the LMC centre. Our findings may either be interpreted as a warped and flared disc in the LMC outskirts, or as evidence of a spheroidal halo component
Target Selection for the Apache Point Observatory Galactic Evolution Experiment (APOGEE)
The Apache Point Observatory Galactic Evolution Experiment (APOGEE) is a
high-resolution infrared spectroscopic survey spanning all Galactic
environments (i.e., bulge, disk, and halo), with the principal goal of
constraining dynamical and chemical evolution models of the Milky Way. APOGEE
takes advantage of the reduced effects of extinction at infrared wavelengths to
observe the inner Galaxy and bulge at an unprecedented level of detail. The
survey's broad spatial and wavelength coverage enables users of APOGEE data to
address numerous Galactic structure and stellar populations issues. In this
paper we describe the APOGEE targeting scheme and document its various target
classes to provide the necessary background and reference information to
analyze samples of APOGEE data with awareness of the imposed selection criteria
and resulting sample properties. APOGEE's primary sample consists of ~100,000
red giant stars, selected to minimize observational biases in age and
metallicity. We present the methodology and considerations that drive the
selection of this sample and evaluate the accuracy, efficiency, and caveats of
the selection and sampling algorithms. We also describe additional target
classes that contribute to the APOGEE sample, including numerous ancillary
science programs, and we outline the targeting data that will be included in
the public data releases.Comment: Accepted to AJ. 31 pages, 11 figure
Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide
Understanding the influence of macromolecular crowding and nanoparticles on
the formation of in-register -sheets, the primary structural component
of amyloid fibrils, is a first step towards describing \emph{in vivo} protein
aggregation and interactions between synthetic materials and proteins. Using
all atom molecular simulations in implicit solvent we illustrate the effects of
nanoparticle size, shape, and volume fraction on oligomer formation of an
amyloidogenic peptide from the transthyretin protein. Surprisingly, we find
that inert spherical crowding particles destabilize in-register -sheets
formed by dimers while stabilizing -sheets comprised of trimers and
tetramers. As the radius of the nanoparticle increases crowding effects
decrease, implying smaller crowding particles have the largest influence on the
earliest amyloid species. We explain these results using a theory based on the
depletion effect. Finally, we show that spherocylindrical crowders destabilize
the ordered -sheet dimer to a greater extent than spherical crowders,
which underscores the influence of nanoparticle shape on protein aggregation
Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease
Background
Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes.
Methods
We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosis < 60) and 141 non-aggressive (low clinical grade, age of diagnosis ≥60) PrCa cases. We conducted rare variant association analyses at gene and gene set levels using SKAT and Bayesian risk index techniques. GO term enrichment analysis was performed for genes with the highest differential burden of rare disruptive variants.
Results
Protein truncating variants (PTVs) in specific DNA repair genes were significantly overrepresented among patients with the aggressive phenotype, with BRCA2, ATM and NBN the most frequently mutated genes. Differential burden of rare variants was identified between metastatic and non-aggressive cases for several genes implicated in angiogenesis, conferring both deleterious and protective effects.
Conclusions
Inherited PTVs in several DNA repair genes distinguish aggressive from non-aggressive PrCa cases. Furthermore, inherited variants in genes with roles in angiogenesis may be potential predictors for risk of metastases. If validated in a larger dataset, these findings have potential for future clinical application
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