1,973 research outputs found
Flavor in Minimal Conformal Technicolor
We construct a complete, realistic, and natural UV completion of minimal
conformal technicolor that explains the origin of quark and lepton masses and
mixing angles. As in "bosonic technicolor", we embed conformal technicolor in a
supersymmetric theory, with supersymmetry broken at a high scale. The exchange
of heavy scalar doublets generates higher-dimension interactions between
technifermions and quarks and leptons that give rise to quark and lepton masses
at the TeV scale. Obtaining a sufficiently large top quark mass requires strong
dynamics at the supersymmetry breaking scale in both the top and technicolor
sectors. This is natural if the theory above the supersymmetry breaking also
has strong conformal dynamics. We present two models in which the strong top
dynamics is realized in different ways. In both models, constraints from
flavor-changing effects can be easily satisfied. The effective theory below the
supersymmetry breaking scale is minimal conformal technicolor with an
additional light technicolor gaugino. We argue that this light gaugino is a
general consequence of conformal technicolor embedded into a supersymmetric
theory. If the gaugino has mass below the TeV scale it will give rise to an
additional pseudo Nambu-Goldstone boson that is observable at the LHC.Comment: 37 pages; references adde
Top and Bottom Seesaw from Supersymmetric Strong Dynamics
We propose a top and bottom seesaw model with partial composite top and
bottom quarks. Such composite quarks and topcolor gauge bosons are bound states
from supersymmetric strong dynamics by Seiberg duality. Supersymmetry breaking
also induces the breaking of topcolor into the QCD gauge coupling. The low
energy description of our model reduces to a complete non-minimal extension of
the top seesaw model with bottom seesaw. The non-minimal nature is crucial for
Higgs mixings and the appearance of light Higgs fields. The Higgs fields are
bound states of partial composite particles with the lightest one compatible
with a 125 GeV Higgs field which was discovered at the LHC.Comment: Minor changes, Published Versio
Spontaneous Parity Violation in SUSY Strong Gauge Theory
We suggest simple models of spontaneous parity violation in supersymmetric
strong gauge theory. We focus on left-right symmetric model and investigate
vacuum with spontaneous parity violation. Non-perturbative effects are
calculable in supersymmetric gauge theory, and we suggest two new models. The
first model shows confinement, and the second model has a dual description of
the theory. The left-right symmetry breaking and electroweak symmetry breaking
are simultaneously occurred with the suitable energy scale hierarchy. The
second model also induces spontaneous supersymmetry breaking.Comment: 14 page
The geography of recent genetic ancestry across Europe
The recent genealogical history of human populations is a complex mosaic
formed by individual migration, large-scale population movements, and other
demographic events. Population genomics datasets can provide a window into this
recent history, as rare traces of recent shared genetic ancestry are detectable
due to long segments of shared genomic material. We make use of genomic data
for 2,257 Europeans (the POPRES dataset) to conduct one of the first surveys of
recent genealogical ancestry over the past three thousand years at a
continental scale. We detected 1.9 million shared genomic segments, and used
the lengths of these to infer the distribution of shared ancestors across time
and geography. We find that a pair of modern Europeans living in neighboring
populations share around 10-50 genetic common ancestors from the last 1500
years, and upwards of 500 genetic ancestors from the previous 1000 years. These
numbers drop off exponentially with geographic distance, but since genetic
ancestry is rare, individuals from opposite ends of Europe are still expected
to share millions of common genealogical ancestors over the last 1000 years.
There is substantial regional variation in the number of shared genetic
ancestors: especially high numbers of common ancestors between many eastern
populations likely date to the Slavic and/or Hunnic expansions, while much
lower levels of common ancestry in the Italian and Iberian peninsulas may
indicate weaker demographic effects of Germanic expansions into these areas
and/or more stably structured populations. Recent shared ancestry in modern
Europeans is ubiquitous, and clearly shows the impact of both small-scale
migration and large historical events. Population genomic datasets have
considerable power to uncover recent demographic history, and will allow a much
fuller picture of the close genealogical kinship of individuals across the
world.Comment: Full size figures available from
http://www.eve.ucdavis.edu/~plralph/research.html; or html version at
http://ralphlab.usc.edu/ibd/ibd-paper/ibd-writeup.xhtm
Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis
This is the final version. Available from the publisher via the DOI in this record.The Osmia bicornis whole genome shotgun project has been deposited at DDBJ/ENA/GenBank under the accession MPJT00000000. The RNAseq data generated in this study has been deposited in the Sequence Read Archive (SRA) under accession SRP065762. Accession numbers of the bee P450 genes manually curated in this study are shown in S5 Table. All other relevant data are within the paper and its Supporting Information files.The impact of pesticides on the health of bee pollinators is determined in part by the capacity of bee detoxification systems to convert these compounds to less toxic forms. For example, recent work has shown that cytochrome P450s of the CYP9Q subfamily are critically important in defining the sensitivity of honey bees and bumblebees to pesticides, including neonicotinoid insecticides. However, it is currently unclear if solitary bees have functional equivalents of these enzymes with potentially serious implications in relation to their capacity to metabolise certain insecticides. To address this question, we sequenced the genome of the red mason bee, Osmia bicornis, the most abundant and economically important solitary bee species in Central Europe. We show that O. bicornis lacks the CYP9Q subfamily of P450s but, despite this, exhibits low acute toxicity to the N-cyanoamidine neonicotinoid thiacloprid. Functional studies revealed that variation in the sensitivity of O. bicornis to N-cyanoamidine and N-nitroguanidine neonicotinoids does not reside in differences in their affinity for the nicotinic acetylcholine receptor or speed of cuticular penetration. Rather, a P450 within the CYP9BU subfamily, with recent shared ancestry to the Apidae CYP9Q subfamily, metabolises thiacloprid in vitro and confers tolerance in vivo. Our data reveal conserved detoxification pathways in model solitary and eusocial bees despite key differences in the evolution of specific pesticide-metabolising enzymes in the two species groups. The discovery that P450 enzymes of solitary bees can act as metabolic defence systems against certain pesticides can be leveraged to avoid negative pesticide impacts on these important pollinators.Biotechnology and Biological Science Research Council (BBSRC)Bayer AGEuropean Research Council (ERC
Contrast Enhanced Micro-Computed Tomography Resolves the 3-Dimensional Morphology of the Cardiac Conduction System in Mammalian Hearts
The general anatomy of the cardiac conduction system (CCS) has been known for 100 years, but its complex and irregular three-dimensional (3D) geometry is not so well understood. This is largely because the conducting tissue is not distinct from the surrounding tissue by dissection. The best descriptions of its anatomy come from studies based on serial sectioning of samples taken from the appropriate areas of the heart. Low X-ray attenuation has formerly ruled out micro-computed tomography (micro-CT) as a modality to resolve internal structures of soft tissue, but incorporation of iodine, which has a high molecular weight, into those tissues enhances the differential attenuation of X-rays and allows visualisation of fine detail in embryos and skeletal muscle. Here, with the use of a iodine based contrast agent (I2KI), we present contrast enhanced micro-CT images of cardiac tissue from rat and rabbit in which the three major subdivisions of the CCS can be differentiated from the surrounding contractile myocardium and visualised in 3D. Structures identified include the sinoatrial node (SAN) and the atrioventricular conduction axis: the penetrating bundle, His bundle, the bundle branches and the Purkinje network. Although the current findings are consistent with existing anatomical representations, the representations shown here offer superior resolution and are the first 3D representations of the CCS within a single intact mammalian heart
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Development of a model colloidal system for rheology simulation.
The objective of the experimental effort is to provide a model particle system that will enable modeling of the macroscopic rheology from the interfacial and environmental structure of the particles and solvent or melt as functions of applied shear and volume fraction of the solid particles. This chapter describes the choice of the model particle system, methods for synthesis and characterization, and results from characterization of colloidal dispersion, particle film formation, and the shear and oscillatory rheology in the system. Surface characterization of the grafted PDMS interface, dispersion characterization of the colloids, and rheological characterization of the dispersions as a function of volume fraction were conducted
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