Reconstruction of delayed scleral flap melting with bovine pericardium after trabeculectomy with mitomycin C.

Aim: To present a challenging case of hypotony after trabeculectomy and its treatment. Case description: A 22-year-old woman with juvenile glaucoma underwent a conventional trabeculectomy with mitomycin C on the right eye (OD). In the immediate postoperative period, we observed a hyperfiltration bleb with hypotony refractory to conservative measures leading to hypotony maculopathy. A surgical revision with scleral flap resuture and conjunctival graft was performed with a satisfactory result and resolution of hypotony maculopathy. After two years, the patient complained of low visual acuity (VA) of the OD. During examination, we observed a fine and avascular bleb with Seidel and visualization of the underlying uveal tissue, an intraocular pressure (IOP) of 5 mmHg, and chorioretinal folds. A new revision of the trabeculectomy was performed. During the procedure, it was not possible to identify the scleral flap, so the fistula was closed with a patch of collagenous membrane derived from bovine pericardium (Tutopatch® graft). A good clinical evolution occurred. After 2 months, IOP was 15 mmHg without Seidel or changes in the fundus and VA was 20/20. After 8 months of follow-up, the IOP remains stable without further complaints. Conclusion: This case illustrates the difficulties faced in the management of a common complication of trabeculectomy and highlights some of the options available for its treatment. There are few reports of scleral melting after trabeculectomy. However, trauma and scleral necrosis associated with mitomycin are listed as the main causes. The use of a scleral patch derived from bovine pericardium allows effective suturing and closure of the aqueous leak.info:eu-repo/semantics/publishedVersio

Frustration-induced quantum phase transitions in a quasi-one-dimensional ferrimagnet: Hard-core boson map and the Ton ks-Girardeau limit

We provide evidence of a superfluid-insulator transition (SIT) of magnons in a quasi-one-dimensional quantum ferrimagnet with {\it isotropic} competing antiferromagnetic spin interactions. This SIT occurs between two distinct ferrimagnetic phases due to the frustration-induced closing of the gap to a magnon excitation. It thus causes a coherent superposition of singlet and triplet states at lattice unit cells and a power-law decay on the staggered spin correlation function along the transverse direction to the spontaneous magnetization. A hard-core boson map suggests that asymptotically close to the SIT the magnons attain the Tonks-Girardeau limit. The quantized nature of the condensed singlets is observed before a first-order transition to a singlet magnetic spiral phase accompanied by critical antiferromagnetic ordering. In the limit of strong frustration, the system undergoes a decoupling transition to an isolated gapped two-leg ladder and a critical single linear chain

Fall risk assessment in elderly with and without history of falls: gait electromyographic analysis: a comparative study

Objectives: To determinate if there were differences in electromyography parameters of rectus anterior, biceps femoris, gluteus medius, soleus, gastrocnemius medialis and tibialis anterior muscles between group with and without history of falls during. Was analized the relationship between the levels of muscle activation and score in POMA (Performance-Oriented Mobility Assessment). Materials and Methods: This is a transversal, not experimental and comparative study. The sample was composed by 30 older adults, 15 with and 15 without history of falls. To collect the data of electromyography was used BIOPAC systems and followed the SENIAM guidelines. For the collection of kinematic data was used Kinovea program and for assess the risk of falling was applied POMA. Results: Individuals with history of falls present levels of muscle activity relatively to maximum voluntary contraction (MVC) higher in the dominant lower limb (right) compared to subjects without a history of falls, however these differences aren´t statistically significant (p>0,05). There is enormous variation between the sample in relation to phases of gait in which the muscles are more actives. The group with history of falls shows values lower than group without history of falls in POMA score, the difference is significant (p=0.001). The relationship between percentage of muscle activation and the values obtained in POMA not proved statistically significant (p>0,05). Conclusion: Although results obtained weren´t statistically significants, we can conclude that individuals with falls have higher levels of muscle activation relative to MVC that individuals without history of falls, it is believed that the changes are related to the development of strategies for increased stability during gait. There is considerable variability in phases in which the subjects engaged higher levels of muscle activation, which might occur due to task compensatory strategies or by the task have been made at speed of comfort for the individual. It follows that POMA is an instrument more sensitive and effective to identify the risk of falling in these individuals that the electromyographic analysis

Fall risk assessment in elderly with and without history of falls: kinematic gait analysis: a comparative study

Objectives: The objective of this research was to verify if there was a variation in the MFC (Minimum Foot Clearance) value among elderly with and without history of falls and, if there were any, verify which joint of the lower limb was responsible for that variation. It was also a main objective to verify if there was a correlation between the risk of falling, achieved through the Timed Up and Go Test (TUG), and the MFC variation. Material and Methods: The sample consisted of a total of 30 elderly who met the inclusion and exclusion criteria. These were divided into the group without history of falls (n=15) and into the group with history of falls (n=15). The MFC and the joint movement amplitudes of the hip, knee and ankle, of the dominant lower limb, were assessed using the Kinovea programme and for the risk of fall assessment it was used the TUG. Results: There were no statistically significant differences in the MFC and TUG values between the groups with and without history of falls. However, there is a decrease of the MFC value for the group with history of falls, being the ankle the joint that most contributed to the MFC variation in the group without history of falls, and the knee in the group with history of falls. About the relation between MFC and TUG, it was obtained a negative correlation (r=-0,269) but it was not significant (p=0,150). Conclusion: In our sample no significant differences in the MFC value were obtained between the group with history of falls and the group without history of falls. Besides the lack of significant differences in the MFC value it was determined the articulation of the lower limb responsible for its variation, and it has been found, although with a p>0,05, that for the group with no history of falls it was the ankle that more contributed to this variation and the knee to the group with history of falls. Concerning to the TUG and MFC value correlation it wasn’t significant. Thus, it was concluded that the TUG use is more effective and sensitive in predicting the risk of falling when compared with the kinematic analysis to obtain the MFC value and the joints amplitude

Fall risk assessment in elderly with and without history of falls: relationship between disorders of balance, fear of falling and gait changes: a comparative study

Objectives: The aim of this study was to assess the changes that occur in the balance, fear of falling and kinematic parameters such as stride length, velocity and time support in elderly with and without a history of falling. Main objective was also to verify whether a relationship exists between changes in gait parameters evaluated, balance and fear of falling. Methods: The sample comprised 30 patients (15 with history of falls and 15 without a history of falls), which met the criteria for inclusion and exclusion. The kinematic evaluation was performed in the dominant leg, which was right in this sample. The stride length, speed and duration of support were assessed using the program Kinovea and for assessment of balance and fear of falling were assessed using the Berg Balance Scale and the Falls Efficacy Scale. Statistical analysis was performed with SPSS version 20. Results: There were no significant differences in the parameters analyzed, except for scores on the Berg Balance Scale (p=0.000) between groups with and without history of falls. However, there is a decrease in the length of the stride and duration of left leg support and the increased length of right leg support, the speed and the fear of falling. The relationship between the parameters obtained, there is only statistically significant result between speed and stride length (r=0.507, p=0.004) and between the score of the Berg Balance Scale and the stride length (r=0.393, p=0,032). Conclusion: Although not having obtained statistically significant results we can conclude that in elderly with a history of falls have changes in speed and stride length that can be related to balance disorders and the aging process itself. However, it is concluded that the use of the Berg Balance Scale is more responsive and effective in the detection of changes occurring in the individual after a fall, and subsequent evaluation of the risk of falling that performing a kinematic analysis

Fall risk assessment in elderly with and without history of falls: strength analysis of lower limb: a comparative study

Objectives: The objective of this research was to analyse muscle performance criteria of the knee joints and ankle flexor and extensor muscles among elderly with and without history of falls. Material and methods: The sample was non-probabilistic, of convenience, comprising a total of 30 elderly (15 with history of falls and 15 without history of falls) who met the inclusion and exclusion criteria. Data were collected through a characterization questionnaire and through the Biodex System Isokinetic Dynamometer. The isokinetic assessment consisted in collecting the Peak Torque per unit of mass (N.m/BW) and ratio FlexorsCon/ExtensorsCon (%) of the knee joints and ankle flexor and extensor muscles, with 5 repetitions and the 60º/s angular speed. This collection has been made in both lower limbs. Results: The sample consisted of 30 individuals, 15 from the group without history of falls and 15 from the group with history of falls with average age of (69,17±4,77) years old. The muscle performance parameters were not significantly different between the groups (p>0,05). Conclusion: The group of elderly with history of falls showed lower Peak Torque numbers per unit of mass (N.m/BW) for the knee and ankle joint comparing with the group without history of falls. In present research also the values of the ratio flexorsCon/ExtensorsCon was analyzed weren't differences found in the knee and ankle joint. Although there are no statistically significant differences between results obtained, approach we believe it will be beneficial to include strengthening exercises for the flexors and extensors muscles of these joints, thereby contributing to the prevention of falls

Library of dispersion-corrected atom-centered potentials for generalized gradient approximation functionals: Elements H, C, N, O, He, Ne, Ar, and Kr

Parameters for analytical dispersion-corrected atom-centered potentials (DCACPs) are presented to improve the description of London dispersion forces within the generalized gradient approximation functionals BLYP, BP, and PBE. A library of DCACPs for hydrogen, carbon, nitrogen, oxygen, helium, neon, argon, and krypton was obtained by calibrating against high-level CCSD(T) or configuration interaction references. The performance and transferability of DCACPs were tested on weakly bound complexes and provide excellent results throughout all investigated systems

Controlling a resonant transmission across the δ′\delta'-potential: the inverse problem

Recently, the non-zero transmission of a quantum particle through the one-dimensional singular potential given in the form of the derivative of Dirac's delta function, $\lambda \delta'(x)$, with $\lambda \in \R$, being a potential strength constant, has been discussed by several authors. The transmission occurs at certain discrete values of $\lambda$ forming a resonance set ${\lambda_n}_{n=1}^\infty$. For $\lambda \notin {\lambda_n}_{n=1}^\infty$ this potential has been shown to be a perfectly reflecting wall. However, this resonant transmission takes place only in the case when the regularization of the distribution $\delta'(x)$ is constructed in a specific way. Otherwise, the $\delta'$-potential is fully non-transparent. Moreover, when the transmission is non-zero, the structure of a resonant set depends on a regularizing sequence $\Delta'_\varepsilon(x)$ that tends to $\delta'(x)$ in the sense of distributions as $\varepsilon \to 0$. Therefore, from a practical point of view, it would be interesting to have an inverse solution, i.e. for a given $\bar{\lambda} \in \R$ to construct such a regularizing sequence $\Delta'_\varepsilon(x)$ that the $\delta'$-potential at this value is transparent. If such a procedure is possible, then this value $\bar{\lambda}$ has to belong to a corresponding resonance set. The present paper is devoted to solving this problem and, as a result, the family of regularizing sequences is constructed by tuning adjustable parameters in the equations that provide a resonance transmission across the $\delta'$-potential.Comment: 21 pages, 4 figures. Corrections to the published version added; http://iopscience.iop.org/1751-8121/44/37/37530

Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study.

OBJECTIVE: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. METHODS: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. RESULTS: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). CONCLUSIONS: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.info:eu-repo/semantics/publishedVersio