Multi-Objective Optimization of FRP Jackets for Improving the Seismic Response of Reinforced Concrete Frames

In this study, a multi-objective Genetic Algorithm (GA) optimization procedure is proposed for the seismic retrofitting of Reinforced Concrete (RC) building frames via Fiber-Reinforced Polymer (FRP) jackets. The optimization problem is solved via numerically efficient but accurate Finite-Element (FE) models able to take into account the strengthening and ductility increase contribution for a given FRP jacketing configuration. Based on a reference RC frame case study, an optimization approach aimed to maximize the frame ductility and minimize the FRP volume/cost is proposed, by taking into account different FRP jackets thicknesses for the internal and external columns and well as for each separate frame floor. In doing so, careful consideration is paid also to the expected collapse mechanism for the frame and the approach to embed a further objective able to control the collapse mechanism into the procedure is described. The results show the potential of the approach, which not only provides the entire Pareto Front of the multi-objective optimization problem, but also allows for general considerations about the influence of the design variables on the response of a given RC building

The Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of Cancer

In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons represent a large family of repeated genomic elements. They transpose using a reverse transcriptase (RT), which they encode as part of the ORF2p product. RT inhibition in cancer cells, either via RNA interference-dependent silencing of active LINE-1 elements, or using RT inhibitory drugs, reduces cancer cell proliferation, promotes their differentiation and antagonizes tumor progression in animal models. Indeed, the nonnucleoside RT inhibitor efavirenz has recently been tested in a phase II clinical trial with metastatic prostate cancer patients. An in-depth analysis of ORF2p in a mouse model of breast cancer showed ORF2p to be precociously expressed in precancerous lesions and highly abundant in advanced cancer stages, while being barely detectable in normal breast tissue, providing a rationale for the finding that RT-expressing tumours are therapeutically sensitive to RT inhibitors. We summarise mechanistic and gene profiling studies indicating that highly abundant LINE-1-derived RT can sequester RNA substrates for reverse transcription in tumor cells, entailing the formation of RNA:DNA hybrid molecules and impairing the overall production of regulatory miRNAs, with a global impact on the cell transcriptome. Based on these data, LINE-1-ORF2 encoded RT has a tumor-promoting potential that is exerted at an epigenetic level. We propose a model whereby LINE1-RT drives a previously unrecognized global regulatory process, the deregulation of which drives cell transformation and tumorigenesis and possibly implicated in cancer cell heterogeneity

Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway

Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, veg- etables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. Furthermore, they also have neuroprotec- tive and cardioprotective effects. Their biological properties depend on the chemical structure of flavonoids, their mechanism of action, and their bioavailability. The beneficial effects of flavonoids have been proven for a variety of diseases. In the last few years, it is demonstrated that the effects of flavonoids are mediated by inhibiting the NF-κB (Nuclear Factor-κB) pathway. In this review, we have summarized the effects of some flavonoids on the most common diseases, such as cancer, car- diovascular, and human neurodegenerative diseases. Here, we collected all recent studies describing the protective and prevention role of flavonoids derived from plants by specifically focusing their action on the NF-κB signaling pathway

Space-Compliant Design of a Millimeter-Wave GaN-on-Si Stacked Power Amplifier Cell through Electro-Magnetic and Thermal Simulations

The stacked power amplifier is a widely adopted solution in CMOS technology to overcome breakdown limits. Its application to compound semiconductor technology is instead rather limited especially at very high frequency, where device parasitic reactances make the design extremely challenging, and in gallium nitride technology, which already offers high breakdown voltages. Indeed, the stacked topology can also be advantageous in such scenarios as it can enhance gain and chip compactness. Moreover, the higher supply voltages and lower supply currents beneficially impact on reliability, thus making the stacked configuration an attractive solution for space applications. This paper details the design of two stacked cells, differing in their inter-stage matching strategy, conceived for space applications at Ka-band in 100 nm GaN-on-Si technology. In particular, the design challenges related to the thermal constraints posed by space reliability and to the electro-magnetic cross-talk issues that may arise at millimeter-wave frequencies are discussed. The best cell achieves at saturation, in simulation, 3 W of output power at 36 GHz with associated gain and efficiency in excess of 7 dB and 35%, respectively

Calling for policy actions to increase access to long-acting antipsychotics in low-income and middle-income countries

Schizophrenia-spectrum disorders are associated with substantial impairment and disability. Lack of treatment adherence is a major issue, especially in low- and middle-income countries (LMICs). Despite growing evidence supporting second-generation long-acting antipsychotics (LAIs) as an effective strategy to ensure continued maintenance treatment in schizophrenia, access to these technologies has been very limited in constrained-resource settings. Including second-generation LAIs in national and international essential medicines lists and evidence-based guidelines, promoting public health-oriented patent pooling and extending their availability to primary health care settings, are key actions that should urgently be implemented to increase access to long-acting technologies. Implementing these policy actions can pragmatically improve treatment adherence, ultimately tackling schizophrenia-related impairment and disability in LMICs, which can be regarded as a global health priority

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation

Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions. Host cuticle/cell wall/membrane components such as sphingolipids and oxylipins may contribute to determining the fate of host–pathogen interactions. In the present field study, we considered the relationship between specific sphingolipids and oxylipins of different hybrids of Zea mays and fumonisin by F. verticillioides, sampling ears at different growth stages from early dough to fully ripe. The amount of total and free fumonisin differed significantly between hybrids and increased significantly with maize ripening. Oxylipins and phytoceramides changed significantly within the hybrids and decreased with kernel maturation, starting from physiological maturity. Although the correlation between fumonisin accumulation and plant lipid profile is certain, the data collected so far cannot define a cause-effect relationship but open up new perspectives. Therefore, the question—“Does fumonisin alter plant lipidome or does plant lipidome modulate fumonisin accumulation?”—is still open