10 research outputs found

    Applications of Engine Noise Control Research

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    Parents, participation, partnership: Problematising New Zealand early childhood education

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    © 2016, © The Author(s) 2016. This article interrogates notions of teacher ‘partnership with parents’ within early childhood care and education settings in the context of Aotearoa (New Zealand). Te Whāriki, the New Zealand early childhood curriculum, clearly positions children’s learning and development as being fostered when their families’ cultures and practices are recognised. Yet findings from both national evaluative reports and recent studies indicate that, in many instances, families that are not members of the dominant cultural group do not experience this synergy. The authors draw on some recent national evaluative reports to paint a broad picture of the implementation of ‘partnership’, and then employ illustrative data from several research projects regarding the inclusion of Māori and Chinese families respectively. The authors apply hybridity theory, along with the related idea of funds of knowledge, to reinforce the need for teachers to proactively move beyond the hegemonic safe zones of traditional teacher-dominated practices towards opening up spaces of dialogic, fluid engagement with families whose backgrounds differ from their own. This aspect of teachers’ professional responsibility is particularly important in the current era of increasing superdiversity

    The UPR and lung disease

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    Apoptotic cell death in disease-Current understanding of the NCCD 2023.

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    Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease

    Targeting the Hippocampal Mossy Fiber Synapse for the Treatment of Psychiatric Disorders

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