Antisocial behavior and alcohol consumption by school adolescents Conducta antisocial y consumo de alcohol en adolescentes escolares Conduta anti-social e consumo de álcool em adolescentes escolares

Adolescence is a vulnerable period and facilitates the start of risk behaviors, for instance the use of drugs. This study aims to describe the differences between antisocial behavior and alcohol consumption according to gender, age and education; as well as to discover the relation between antisocial behavior and alcohol consumption in 1,221 school adolescents from Monterrey - Nuevo Leon, Mexico. The findings reveal differences in antisocial behavior according to gender. Evidences showed that 41.3% of the students had consumed alcohol at sometime in their lives, and that differences exist in alcohol consumption according to age and education. Finally, the study found positive and significant relations between antisocial behavior and alcohol consumption (r s = .272, p <.001).<br>La adolescencia se convierte en una etapa de vulnerabilidad y facilitador para el inicio de conductas de riesgo como es el consumo de drogas. Los objetivos del presente estudio fueron: describir las diferencias de la conducta antisocial y consumo de alcohol según sexo, edad y escolaridad; conocer la relación existente de la conducta antisocial con el consumo de alcohol en 1221 adolescentes escolares de Monterrey, Nuevo Léon, México, en relación a los hallazgos encontrados se presentan diferencias de la conducta antisocial por sexo; se destaca que 41.3% de los estudiantes consumieron alcohol alguna vez en su vida, y existen diferencias de consumo de alcohol por edad y escolaridad. Finalmente se encontró relación positiva y significativa de la conducta antisocial con el consumo de alcohol (r s=.272, p<.001).<br>A adolescência se apresenta como uma etapa de vulnerabilidade e facilitadora para o início de condutas de risco como o consumo de drogas. Os objetivos do presente estudo foram: descrever as diferenças entre sexo, idade e escolaridade na conduta anti-social e o consumo de álcool e conhecer a relação existente entre a conduta anti-social e o consumo de álcool em 1221 adolescentes escolares de Monterrey, Nuevo León, México. De acordo com os resultados obtidos foram observadas diferenças na conduta anti-social por sexo. Destaca-se que 41,3% dos estudantes consumiram álcool em algum momento da vida, e houve diferenças de consumo de álcool por idade e escolaridade. Finalmente, encontrou-se uma relação positiva e significativa entre a conduta anti-social e o consumo de álcool (r s=,272, p<,001)

Dissection of antibody specificities induced by yellow fever vaccination

The live attenuated yellow fever (YF) vaccine has an excellent record of efficacy and one dose provides long-lasting immunity, which in many cases may last a lifetime. Vaccination stimulates strong innate and adaptive immune responses, and neutralizing antibodies are considered to be the major effectors that correlate with protection from disease. Similar to other flaviviruses, such antibodies are primarily induced by the viral envelope protein E, which consists of three distinct domains (DI, II, and III) and is presented at the surface of mature flavivirions in an icosahedral arrangement. In general, the dominance and individual variation of antibodies to different domains of viral surface proteins and their impact on neutralizing activity are aspects of humoral immunity that are not well understood. To gain insight into these phenomena, we established a platform of immunoassays using recombinant proteins and protein domains that allowed us to dissect and quantify fine specificities of the polyclonal antibody response after YF vaccination in a panel of 51 vaccinees as well as determine their contribution to virus neutralization by serum depletion analyses. Our data revealed a high degree of individual variation in antibody specificities present in post-vaccination sera and differences in the contribution of different antibody subsets to virus neutralization. Irrespective of individual variation, a substantial proportion of neutralizing activity appeared to be due to antibodies directed to complex quaternary epitopes displayed on the virion surface only but not on monomeric E. On the other hand, DIII-specific antibodies (presumed to have the highest neutralizing activity) as well as broadly flavivirus cross-reactive antibodies were absent or present at very low titers. These data provide new information on the fine specificity as well as variability of antibody responses after YF vaccination that are consistent with a strong influence of individual-specific factors on immunodominance in humoral immune responses