Resolving Architectural Mismatches of COTS Through Architectural Reconciliation

The integration of COTS components into a system under development entails architectural mismatches. These have been tackled, so far, at the component level, through component adaptation techniques, but they also must be tackled at an architectural level of abstraction. In this paper we propose an approach for resolving architectural mismatches, with the aid of architectural reconciliation. The approach consists of designing and subsequently reconciling two architectural models, one that is forward-engineered from the requirements and another that is reverse-engineered from the COTS-based implementation. The final reconciled model is optimally adapted both to the requirements and to the actual COTS-based implementation. The contribution of this paper lies in the application of architectural reconciliation in the context of COTS-based software development. Architectural modeling is based upon the UML 2.0 standard, while the reconciliation is performed by transforming the two models, with the help of architectural design decisions.

Nuclear gas dynamics in Arp 220 - sub-kiloparsec scale atomic hydrogen disks

We present new, high angular resolution (~0.22") MERLIN observations of neutral hydrogen (HI) absorption and 21-cm radio continuum emission across the central ~900 parsecs of the ultraluminous infrared galaxy, Arp220. Spatially resolved HI absorption is detected against the morphologically complex and extended 21-cm radio continuum emission, consistent with two counterrotating disks of neutral hydrogen, with a small bridge of gas connecting the two. We propose a merger model in which the two nuclei represent the galaxy cores which have survived the initial encounter and are now in the final stages of merging, similar to conclusions drawn from previous CO studies (Sakamoto, Scoville & Yun 1999). However, we suggest that instead of being coplanar with the main CO disk (in which the eastern nucleus is embedded), the western nucleus lies above it and, as suggested by bridge of HI connecting the two nuclei, will soon complete its final merger with the main disk. We suggest that the collection of radio supernovae (RSN) detected in VLBA studies in the more compact western nucleus represent the second burst of star formation associated with this final merger stage and that free-free absorption due to ionised gas in the bulge-like component can account for the observed RSN distribution. (Abridged)Comment: 26 pages including 8 figures and 1 table; accepted for publication in Ap

Lentiviral manipulation of gene expression in human adult and embryonic stem cells

Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery. To achieve this goal, genetic tools need to be optimized and developed for controlling and manipulating stem cells ex vivo. Here we describe a lentiviral delivery system capable of high infection rates in human mesenchymal and embryonic stem cells. The lentiviral backbone was modified to express mono- and bi-cistronic transgenes and was also used to deliver short hairpin ribonucleic acid for specific silencing of gene expression in human stem cells. We show that lentiviral transduction can be used to alter gene expression without altering the genes' ability to differentiate in vitro. These vectors will enable rapid analysis of gene function in stem cells and permit the generation of knock-in / knock-out models of human disease in the rapidly developing field of gene therapy

Chandra Observations of Extended X-ray Emission in Arp 220

We resolve the extended X-ray emission from the prototypical ultraluminous infrared galaxy Arp 220. Extended, faint edge-brightened, soft X-ray lobes outside the optical galaxy are observed to a distance of 10 to 15 kpc on each side of the nuclear region. Bright plumes inside the optical isophotes coincide with the optical line emission and extend 11 kpc from end to end across the nucleus. The data for the plumes cannot be fit by a single temperature plasma, and display a range of temperatures from 0.2 to 1 keV. The plumes emerge from bright, diffuse circumnuclear emission in the inner 3 kpc centered on the Halpha peak, which is displaced from the radio nuclei. There is a close morphological correspondence between the Halpha and soft X-ray emission on all spatial scales. We interpret the plumes as a starburst-driven superwind, and discuss two interpretations of the emission from the lobes in the context of simulations of the merger dynamics of Arp 220.Comment: Accepted for publication in ApJ; see also astro-ph/0208477 (Paper 1

Chandra Observations of Arp 220: The Nuclear Source

We present the first results from 60ks of observations of Arp 220 using the ACIS-S instrument on Chandra. We report the detection of several sources near the galaxy's nucleus, including a point source with a hard spectrum that is coincident with the western radio nucleus B. This point source is mildly absorbed (N_H ~ 3 x 10^22 cm^-2) and has an estimated luminosity of 4 x 10^40 erg/s. In addition, a fainter source may coincide with the eastern nucleus A. Extended hard X-ray emission in the vicinity raises the total estimated nuclear 2-10 keV X-ray luminosity to 1.2 x 10^41 erg/s, but we cannot rule out a hidden AGN behind columns exceeding 5 x 10^24 cm^-2. We also detect a peak of soft X-ray emission to the west of the nucleus, and a hard point source 2.5 kpc from the nucleus with a luminosity of 6 x 10^39 erg/s.Comment: Accepted for publication in Ap

Chandra Observations of Arp 220: The Nuclear Source

We present the first results from 60ks of observations of Arp 220 using the ACIS-S instrument on Chandra. We report the detection of several sources near the galaxy's nucleus, including a point source with a hard spectrum that is coincident with the western radio nucleus B. This point source is mildly absorbed (N_H ~ 3 x 10^22 cm^-2) and has an estimated luminosity of 4 x 10^40 erg/s. In addition, a fainter source may coincide with the eastern nucleus A. Extended hard X-ray emission in the vicinity raises the total estimated nuclear 2-10 keV X-ray luminosity to 1.2 x 10^41 erg/s, but we cannot rule out a hidden AGN behind columns exceeding 5 x 10^24 cm^-2. We also detect a peak of soft X-ray emission to the west of the nucleus, and a hard point source 2.5 kpc from the nucleus with a luminosity of 6 x 10^39 erg/s.Comment: Accepted for publication in Ap

How to Complete an Interactive Configuration Process?

When configuring customizable software, it is useful to provide interactive tool-support that ensures that the configuration does not breach given constraints. But, when is a configuration complete and how can the tool help the user to complete it? We formalize this problem and relate it to concepts from non-monotonic reasoning well researched in Artificial Intelligence. The results are interesting for both practitioners and theoreticians. Practitioners will find a technique facilitating an interactive configuration process and experiments supporting feasibility of the approach. Theoreticians will find links between well-known formal concepts and a concrete practical application.Comment: to appear in SOFSEM 201

An Optimal Design for Universal Multiport Interferometers

Universal multiport interferometers, which can be programmed to implement any linear transformation between multiple channels, are emerging as a powerful tool for both classical and quantum photonics. These interferometers are typically composed of a regular mesh of beam splitters and phase shifters, allowing for straightforward fabrication using integrated photonic architectures and ready scalability. The current, standard design for universal multiport interferometers is based on work by Reck et al (Phys. Rev. Lett. 73, 58, 1994). We demonstrate a new design for universal multiport interferometers based on an alternative arrangement of beam splitters and phase shifters, which outperforms that by Reck et al. Our design occupies half the physical footprint of the Reck design and is significantly more robust to optical losses.Comment: 8 pages, 4 figure