Intersegmental Coordination in the Kinematics of Prehension Movements of Macaques

The most popular model to explain how prehensile movements are organized assumes that they comprise two "components", the reaching component encoding information regarding the object's spatial location and the grasping component encoding information on the object's intrinsic properties such as size and shape. Comparative kinematic studies on grasping behavior in the humans and in macaques have been carried out to investigate the similarities and differences existing across the two species. Although these studies seem to favor the hypothesis that macaques and humans share a number of kinematic features it remains unclear how the reaching and grasping components are coordinated during prehension movements in free-ranging macaque monkeys. Twelve hours of video footage was filmed of the monkeys as they snatched food items from one another (i.e., snatching) or collect them in the absence of competitors (i.e., unconstrained). The video samples were analyzed frame-by-frame using digitization techniques developed to perform two-dimensional post-hoc kinematic analyses of the two types of actions. The results indicate that only for the snatching condition when the reaching variability increased there was an increase in the amplitude of maximum grip aperture. Besides, the start of a break-point along the deceleration phase of the velocity profile correlated with the time at which maximum grip aperture occurred. These findings suggest that macaques can spatially and temporally couple the reaching and the grasping components when there is pressure to act quickly. They offer a substantial contribution to the debate about the nature of how prehensile actions are programmed

Stoquasticity in circuit QED

We analyze whether circuit-QED Hamiltonians are stoquastic focusing on systems of coupled flux qubits: we show that scalable sign-problem free path integral Monte Carlo simulations can typically be performed for such systems. Despite this, we corroborate the recent finding [arXiv:1903.06139] that an effective, non-stoquastic qubit Hamiltonian can emerge in a system of capacitively coupled flux qubits. We find that if the capacitive coupling is sufficiently small, this non-stoquasticity of the effective qubit Hamiltonian can be avoided if we perform a canonical transformation prior to projecting onto an effective qubit Hamiltonian. Our results shed light on the power of circuit-QED Hamiltonians for the use of quantum adiabatic computation and the subtlety of finding a representation which cures the sign problem in these system

Torsion pendulum facility for direct force measurements of LISA GRS related disturbances

A four mass torsion pendulum facility for testing of the LISA GRS is under development in Trento. With a LISA-like test mass suspended off-axis with respect to the pendulum fiber, the facility allows for a direct measurement of surface force disturbances arising in the GRS. We present here results with a prototype pendulum integrated with very large-gap sensors, which allows an estimate of the intrinsic pendulum noise floor in the absence of sensor related force noise. The apparatus has shown a torque noise near to its mechanical thermal noise limit, and would allow to place upper limits on GRS related disturbances with a best sensitivity of 300 fN/Hz^(1/2) at 1mHz, a factor 50 from the LISA goal. Also, we discuss the characterization of the gravity gradient noise, one environmental noise source that could limit the apparatus performances, and report on the status of development of the facility.Comment: Submitted to Proceedings of the 6th International LISA Symposium, AIP Conference Proceedings 200

Homological Quantum Rotor Codes: Logical Qubits from Torsion

We formally define homological quantum rotor codes which use multiple quantum rotors to encode logical information. These codes generalize homological or CSS quantum codes for qubits or qudits, as well as linear oscillator codes which encode logical oscillators. Unlike for qubits or oscillators, homological quantum rotor codes allow one to encode both logical rotors and logical qudits, depending on the homology of the underlying chain complex. In particular, such a code based on the chain complex obtained from tessellating the real projective plane or a M\"{o}bius strip encodes a qubit. We discuss the distance scaling for such codes which can be more subtle than in the qubit case due to the concept of logical operator spreading by continuous stabilizer phase-shifts. We give constructions of homological quantum rotor codes based on 2D and 3D manifolds as well as products of chain complexes. Superconducting devices being composed of islands with integer Cooper pair charges could form a natural hardware platform for realizing these codes: we show that the $0$-$\pi$-qubit as well as Kitaev's current-mirror qubit -- also known as the M\"{o}bius strip qubit -- are indeed small examples of such codes and discuss possible extensions.Comment: 47 pages, 10 figures, 2 table

Use of surrogate endpoints in healthcare policy : proposal for consistent adoption of a validation framework

We propose a three step framework for the evaluation of surrogate endpoints for health policy decisions on health technologies

Surrogate endpoints in trials-a call for better reporting

Better reporting of RCTs with primary surrogate endpoints

Ecological Distribution and Oenological Characterization of Native Saccharomyces cerevisiae in an Organic Winery

The relation between regional yeast biota and the organoleptic characteristics of wines has attracted growing attention among winemakers. In this work, the dynamics of a native Saccharomyces cerevisiae population was investigated in an organic winery. In this regard, the occurrence and the persistence of native S. cerevisiae were evaluated in the vineyard and winery and during spontaneous fermentation of two nonconsecutive vintages. From a total of 98 strains, nine different S. cerevisiae biotypes were identified that were distributed through the whole winemaking process, and five of them persisted in both vintages. The results of the oenological characterization of the dominant biotypes (I and II) show a fermentation behavior comparable to that exhibited by three common commercial starter strains, exhibiting specific aromatic profiles. Biotype I was characterized by some fruity aroma compounds, such as isoamyl acetate and ethyl octanoate, while biotype II was differentiated by ethyl hexanoate, nerol, and β-damascenone production also in relation to the fermentation temperature. These results indicate that the specificity of these resident strains should be used as starter cultures to obtain wines with distinctive aromatic profiles