A quantum analog of Huffman coding

We analyze a generalization of Huffman coding to the quantum case. In particular, we notice various difficulties in using instantaneous codes for quantum communication. Nevertheless, for the storage of quantum information, we have succeeded in constructing a Huffman-coding inspired quantum scheme. The number of computational steps in the encoding and decoding processes of N quantum signals can be made to be of polylogarithmic depth by a massively parallel implementation of a quantum gate array. This is to be compared with the O (N^3) computational steps required in the sequential implementation by Cleve and DiVincenzo of the well-known quantum noiseless block coding scheme of Schumacher. We also show that O(N^2(log N)^a) computational steps are needed for the communication of quantum information using another Huffman-coding inspired scheme where the sender must disentangle her encoding device before the receiver can perform any measurements on his signals.Comment: Revised version, 7 pages, two-column, RevTex. Presented at 1998 IEEE International Symposium on Information Theor

Intrinsic tethering activity of endosomal Rab proteins.

Rab small G proteins control membrane trafficking events required for many processes including secretion, lipid metabolism, antigen presentation and growth factor signaling. Rabs recruit effectors that mediate diverse functions including vesicle tethering and fusion. However, many mechanistic questions about Rab-regulated vesicle tethering are unresolved. Using chemically defined reaction systems, we discovered that Vps21, a Saccharomyces cerevisiae ortholog of mammalian endosomal Rab5, functions in trans with itself and with at least two other endosomal Rabs to directly mediate GTP-dependent tethering. Vps21-mediated tethering was stringently and reversibly regulated by an upstream activator, Vps9, and an inhibitor, Gyp1, which were sufficient to drive dynamic cycles of tethering and detethering. These experiments reveal a previously undescribed mode of tethering by endocytic Rabs. In our working model, the intrinsic tethering capacity Vps21 operates in concert with conventional effectors and SNAREs to drive efficient docking and fusion

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition

BACKGROUND: Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression and activity of variety of downstream targets. Resistance to TGFβ-mediated cytostasis is one of the growth transforming effects of LMP1. Of the downstream targets manipulated by LMP1, the induction of Id1 and inactivation of Foxo3a appear particularly relevant to LMP1-mediated effects. Id1, a HLH protein is implicated in cell transformation and plays a role in cell proliferation, whilst Foxo3a, a transcription factor controls cell integrity and homeostasis by regulating apoptosis. The mechanism(s) by which LMP1 induces these effects have not been fully characterised. RESULTS: In this study, we demonstrate that the ability of LMP1 to induce the phosphorylation and inactivation of Foxo3a is linked to the upregulation of Id1. Furthermore, we show that the induction of Id1 is essential for the transforming function of LMP1 as over-expression of Id1 increases cell proliferation, attenuates TGFβ-SMAD-mediated transcription and renders cells refractory to TGFβ-mediated cytostasis. Id1 silencing in LMP1-expressing epithelial cells abolishes the inhibitory effect of LMP1 on TGFβ-mediated cell growth arrest and reduces the ability of LMP1 to attenuate SMAD transcriptional activity. In response to TGFβ stimulation, LMP1 does not abolish SMAD phosphorylation but inhibits p21 protein expression. In addition, we found the induction of Id1 in LMP1-expressing cells upon stimulation by TGFβ. We provide evidence that LMP1 suppresses the transcriptional repressor ATF3, possibly leading to the TGFβ-induced Id1 upregulation. CONCLUSION: The current data provide novel information regarding the mechanisms by which LMP1 suppresses TGFβ-induced cytostasis, highlighting the importance of Id1 in LMP1 mediated cell transformatio

Formation and Trend of Guanxi Practice and Guanxi Phenomenon

Abstract: With the increase of interactions between Chinese and international communities, guanxi, a Chinese term, has catching more and more attentions from non-Chinese speaking people. Guanxi, from a sociological perspective, is formed on the ascribed, social or third party bases through the mechanism of ganqing and renqing. Different from other scholars, the authors consider guanxi phenomenon is an outcome of co-impacts from Confucianism and institutionalization of material factors and structural factors. It is argued that guanxi phenomenon will decline in future China gradually because of rationalization required by capitalism but will not disappear completely due to human nature and cultural nature

Mapping Circumgalactic Medium Observations to Theory Using Machine Learning

We present a random forest framework for predicting circumgalactic medium (CGM) physical conditions from quasar absorption line observables, trained on a sample of Voigt profile-fit synthetic absorbers from the Simba cosmological simulation. Traditionally, extracting physical conditions from CGM absorber observations involves simplifying assumptions such as uniform single-phase clouds, but by using a cosmological simulation we bypass such assumptions to better capture the complex relationship between CGM observables and underlying gas conditions. We train random forest models on synthetic spectra for HI and selected metal lines around galaxies across a range of star formation rates, stellar masses, and impact parameters, to predict absorber overdensities, temperatures, and metallicities. The models reproduce the true values from Simba well, with normalised transverse standard deviations of $0.50-0.54$ dex in overdensity, $0.32-0.54$ dex in temperature, and $0.49-0.53$ dex in metallicity predicted from metal lines (not HI), across all ions. Examining the feature importance, the random forest indicates that the overdensity is most informed by the absorber column density, the temperature is driven by the line width, and the metallicity is most sensitive to the specific star formation rate. Alternatively examining feature importance by removing one observable at a time, the overdensity and metallicity appear to be more driven by the impact parameter. We introduce a normalising flow approach in order to ensure the scatter in the true physical conditions is accurately spanned by the network. The trained models are available online.Comment: 16 pages, 14 figures. Accepted for publication in MNRA

Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques.

Zika virus (ZIKV) is a mosquito-transmitted virus that can cause severe defects in an infected fetus. ZIKV is also transmitted by sexual contact, although the relative importance of sexual transmission is unclear. To better understand the role of sexual transmission in ZIKV pathogenesis, a nonhuman primate (NHP) model of vaginal transmission was developed. ZIKV was readily transmitted to mature cycling female rhesus macaque (RM) by vaginal inoculation with 104-106 plaque-forming units (PFU). However, there was variability in susceptibility between the individual RM with 1->8 vaginal inoculations required to establish infection. After treatment with Depoprovera, a widely used contraceptive progestin, two RM that initially resisted 8 vaginal ZIKV inoculations became infected after one ZIKV inoculation. Thus, Depoprovera seemed to enhance susceptibility to vaginal ZIKV transmission. Unexpectedly, the kinetics of virus replication and dissemination after intravaginal ZIKV inoculation were markedly different from RM infected with ZIKV by subcutaneous (SQ) virus inoculation. Several groups have reported that after SQ ZIKV inoculation vRNA is rapidly detected in blood plasma with vRNA less common in urine and saliva and only rarely detected in female reproductive tract (FRT) secretions. In contrast, in vaginally inoculated RM, plasma vRNA is delayed for several days and ZIKV replication in, and vRNA shedding from, the FRT was found in all 6 animals. Further, after intravaginal transmission ZIKV RNA shedding from FRT secretions was detected before or simultaneously with plasma vRNA, and persisted for at least as long. Thus, ZIKV replication in the FRT was independent of, and often preceded virus replication in the tissues contributing to plasma vRNA. These results support the conclusion that ZIKV preferentially replicates in the FRT after vaginal transmission, but not after SQ transmission, and raise the possibility that there is enhanced fetal infection and pathology after vaginal ZIKV transmission compared to a mosquito transmitted ZIKV

Quantum Coherence at Low Temperatures in Mesoscopic Systems: Effect of Disorder

We study the disorder dependence of the phase coherence time of quasi one-dimensional wires and two-dimensional (2D) Hall bars fabricated from a high mobility GaAs/AlGaAs heterostructure. Using an original ion implantation technique, we can tune the intrinsic disorder felt by the 2D electron gas and continuously vary the system from the semi-ballistic regime to the localized one. In the diffusive regime, the phase coherence time follows a power law as a function of diffusion coefficient as expected in the Fermi liquid theory, without any sign of low temperature saturation. Surprisingly, in the semi-ballistic regime, it becomes independent of the diffusion coefficient. In the strongly localized regime we find a diverging phase coherence time with decreasing temperature, however, with a smaller exponent compared to the weakly localized regime.Comment: 21 pages, 30 figure

Mapping circumgalactic medium observations to theory using machine learning

We present a random forest (RF) framework for predicting circumgalactic medium (CGM) physical conditions from quasar absorption line observables, trained on a sample of Voigt profile-fit synthetic absorbers from the SIMBA cosmological simulation. Traditionally, extracting physical conditions from CGM absorber observations involves simplifying assumptions such as uniform single-phase clouds, but by using a cosmological simulation we bypass such assumptions to better capture the complex relationship between CGM observables and underlying gas conditions. We train RF models on synthetic spectra for H I and selected metal lines around galaxies across a range of star formation rates, stellar masses, and impact parameters, to predict absorber overdensities, temperatures, and metallicities. The models reproduce the true values from SIMBA well, with normalized transverse standard deviations of 0.50–0.54 dex in overdensity, 0.32–0.54 dex in temperature, and 0.49–0.53 dex in metallicity predicted from metal lines (not H I), across all ions. Examining the feature importance, the RF indicates that the overdensity is most informed by the absorber column density, the temperature is driven by the line width, and the metallicity is most sensitive to the specific star formation rate. Alternatively examining feature importance by removing one observable at a time, the overdensity and metallicity appear to be more driven by the impact parameter. We introduce a normalizing flow approach in order to ensure the scatter in the true physical conditions is accurately spanned by the network. The trained models are available online

CO(1-0) in z ≳ 4 Quasar Host Galaxies: No Evidence for Extended Molecular Gas Reservoirs

We present ^(12)CO(J = 1 → 0) observations of the high-redshift quasi-stellar objects (QSOs) BR 1202-0725 (z = 4.69), PSS J2322+1944 (z = 4.12), and APM 08279+5255 (z = 3.91) using the NRAO Green Bank Telescope (GBT) and the MPIfR Effelsberg 100 m telescope. We detect, for the first time, the CO ground-level transition in BR 1202-0725. For PSS J2322+1944 and APM 08279+5255, our observations result in line fluxes that are consistent with previous NRAO Very Large Array (VLA) observations, but they reveal the full line profiles. We report a typical lensing-corrected velocity-integrated intrinsic ^(12)CO(J = 1 → 0) line luminosity of L'_(CO) = 5 × 10^(10) K km s^(-1) pc^2 and a typical total H_2 mass of M(H_2) = 4 × 10^(10) M_☉ for the sources in our sample. The CO/FIR luminosity ratios of these high-z sources follow the same trend as seen for low-z galaxies, leading to a combined solution of log L_(FIR) = (1.39 ± 0.05) log L_(CO) - 1.76. It has previously been suggested that the molecular gas reservoirs in some quasar host galaxies may exhibit luminous, extended ^(12)CO(J = 1 → 0) components that are not observed in the higher J CO transitions. Using the line profiles and the total intensities of our observations and large velocity gradient (LVG) models based on previous results for higher J CO transitions, we derive that emission from all CO transitions is described well by a single gas component in which all molecular gas is concentrated in a compact nuclear region. Thus, our observations and models show no indication of a luminous extended, low surface brightness molecular gas component in any of the high-redshift QSOs in our sample. If such extended components exist, their contribution to the overall luminosity is limited to at most 30%