623 research outputs found

    Analysis on the changes of convergence of regional economic growth in China: 1984-2010

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    I den här konsumtionsuppsatsen ligger fokus på hur livet i Sverige skildras för både en etnisk svensk och för en invandrare i läroböcker för SFI samt svenska som andraspråk. Forskningsområdet är tämligen outforskat och litteraturen som har använts i arbetet har hittats via litteratursökningar i olika databaser samt bibliotekets katalog. Som metod har jag använt mig av allmän litteraturstudie och har valt studier utifrån ämnesrelevans för uppsatsen.Först och främst skildras lärobokens roll i samhället och vikten av läromedelsanalyser samt de relevanta forskningsfrågorna. Därefter får man läsa om hur arbetet har skrivits och analyserats utifrån ett forskningsöversiktligt perspektiv. Detta följs av själva analysen där man kommer fram till att den analyserade litteraturen pekar på att det ofta skildras en stereotyp bild av Sverige och dess invånare i läroböcker inom SFI och svenska som andraspråk. Sist får man läsa en avslutande diskussion där ämnet problematiseras, metoderna jämförs, vilka didaktiska implikationer ämnet har samt förslag till vidare studier

    Validation of Konsung Compass 2000 Dry Biochemical Analyzer

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    Dry biochemical analyzers have been increasingly popular in many tests by primary hospitals, field hospitals and other areas subject to economic and medical underdevelopment as well as poor transportation. With the increasing demand for POCT in primary medical care around the world, upgrading of dry biochemical analyzers has been a hot topic in technical research. Against such context, Konsung Compass2000 dry biochemical analyzer, a POCT system with high precision and accuracy, is developed. Furthermore, the upgraded dry biochemical analyzers can, in a more convenient and accurate way, monitor glucose, lipid and other indices affecting the course of chronic diseases

    Gate-controlled reversible rectifying behaviour in tunnel contacted atomically-thin MoS2_{2} transistor

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    Atomically-thin 2D semiconducting materials integrated into van der Waals heterostructures have enabled architectures that hold great promise for next generation nanoelectronics. However, challenges still remain to enable their full acceptance as compliant materials for integration in logic devices. Two key-components to master are the barriers at metal/semiconductor interfaces and the mobility of the semiconducting channel, which endow the building-blocks of pn{pn} diode and field effect transistor. Here, we have devised a reverted stacking technique to intercalate a wrinkle-free h-BN tunnel layer between MoS2_{2} channel and contacting electrodes. Vertical tunnelling of electrons therefore makes it possible to suppress the Schottky barriers and Fermi level pinning, leading to homogeneous gate-control of the channel chemical potential across the bandgap edges. The observed unprecedented features of ambipolar pn{pn} to np{np} diode, which can be reversibly gate tuned, paves the way for future logic applications and high performance switches based on atomically thin semiconducting channel.Comment: 23 pages, 5 main figures + 9 SI figure

    Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

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    Traditional Chinese medicine (TCM) has displayed preventive and therapeutic effects on many complex diseases. As natural biological macromolecules, TCM-derived antiobesogenic polysaccharides (TCMPOs) exhibit notable weight-loss effects and are seen to be a viable tactic in the fight against obesity. Current studies demonstrate that the antiobesity activity of TCMPOs is closely related to their structural characteristics, which could be affected by the extraction and purification methods. Therefore, the extraction, purification and structural-property correlations of TCMPOs were discussed. Investigation of the antiobesity mechanism of TCMPOs is also essential for their improved application. Herein, the possible antiobesity mechanisms of TCMPOs are systematically summarized: (1) modulation of appetite and satiety effects, (2) suppression of fat absorption and synthesis, (3) alteration of the gut microbiota and their metabolites, and (4) protection of intestinal barriers. This collated information could provide some insights and offer a new therapeutic approach for the management and prevention of obesity

    Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

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    Deadenylation is the major step triggering mammalian mRNA decay. One consequence of deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]). Nontranslatable mRNPs may accumulate in P-bodies, which contain factors involved in translation repression, decapping, and 5′-to-3′ degradation. We demonstrate that deadenylation is required for mammalian P-body formation and mRNA decay. We identify Pan2, Pan3, and Caf1 deadenylases as new P-body components and show that Pan3 helps recruit Pan2, Ccr4, and Caf1 to P-bodies. Pan3 knockdown causes a reduction of P-bodies and has differential effects on mRNA decay. Knocking down Caf1 or overexpressing a Caf1 catalytically inactive mutant impairs deadenylation and mRNA decay. P-bodies are not detected when deadenylation is blocked and are restored when the blockage is released. When deadenylation is impaired, P-body formation is not restorable, even when mRNAs exit the translating pool. These results support a dynamic interplay among deadenylation, mRNP remodeling, and P-body formation in selective decay of mammalian mRNA
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